ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	194/1123	423/7206	6.62976412041e-53
ko04724	Glutamatergic synapse	86/1123	152/7206	7.32952859813e-32
ko05033	Nicotine addiction	47/1123	56/7206	9.00755782302e-30
ko04713	Circadian entrainment	72/1123	136/7206	2.04800288418e-24
ko04727	GABAergic synapse	63/1123	110/7206	5.5949546958e-24
ko05032	Morphine addiction	63/1123	110/7206	5.5949546958e-24
ko04721	Synaptic vesicle cycle	52/1123	80/7206	1.28556955433e-23
ko04728	Dopaminergic synapse	84/1123	185/7206	1.8356251071e-22
ko04725	Cholinergic synapse	74/1123	160/7206	1.73506344462e-20
ko04723	Retrograde endocannabinoid signaling	75/1123	175/7206	2.31718448132e-18
ko04024	cAMP signaling pathway	98/1123	279/7206	2.16312742459e-16
ko04020	Calcium signaling pathway	94/1123	265/7206	4.08801131049e-16
ko04742	Taste transduction	37/1123	61/7206	1.04656806257e-15
ko04726	Serotonergic synapse	58/1123	137/7206	3.55366505e-14
ko04911	Insulin secretion	52/1123	117/7206	7.24631746096e-14
ko04921	Oxytocin signaling pathway	76/1123	209/7206	7.77002776685e-14
ko04720	Long-term potentiation	44/1123	99/7206	6.24829233947e-12
ko04261	Adrenergic signaling in cardiomyocytes	71/1123	205/7206	1.2116159144e-11
ko05031	Amphetamine addiction	40/1123	91/7206	8.77512987055e-11
ko04970	Salivary secretion	40/1123	95/7206	4.32663857067e-10
ko03040	Spliceosome	1/1123	145/7206	8.36303727814e-10
ko05203	Viral carcinogenesis	12/1123	277/7206	3.03772515663e-09
ko04744	Phototransduction	21/1123	36/7206	4.94036598478e-09
ko04740	Olfactory transduction	34/1123	80/7206	6.67163378476e-09
ko04360	Axon guidance	70/1123	233/7206	1.88668087712e-08
ko04060	Cytokine-cytokine receptor interaction	6/1123	191/7206	4.13226973518e-08
ko05168	Herpes simplex infection	6/1123	182/7206	1.2531275503e-07
ko05164	Influenza A	5/1123	167/7206	2.07102142627e-07
ko04540	Gap junction	43/1123	128/7206	3.79802054397e-07
ko05030	Cocaine addiction	29/1123	73/7206	4.94009088165e-07
ko04971	Gastric acid secretion	35/1123	98/7206	7.59601879099e-07
ko03013	RNA transport	6/1123	166/7206	1.19119632256e-06
ko04022	cGMP-PKG signaling pathway	61/1123	216/7206	1.40821144495e-06
ko04925	Aldosterone synthesis and secretion	36/1123	105/7206	1.85396505123e-06
ko04120	Ubiquitin mediated proteolysis	4/1123	138/7206	2.25447354124e-06
ko04924	Renin secretion	31/1123	86/7206	2.84603451985e-06
ko04514	Cell adhesion molecules (CAMs)	41/1123	130/7206	3.9897679274e-06
ko04010	MAPK signaling pathway	81/1123	321/7206	4.2751849306e-06
ko04966	Collecting duct acid secretion	14/1123	26/7206	7.01513920071e-06
ko05322	Systemic lupus erythematosus	6/1123	151/7206	1.11926397728e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	27/1123	74/7206	1.16114954207e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1123	79/7206	1.21296236799e-05
ko04730	Long-term depression	27/1123	78/7206	2.67677131364e-05
ko04260	Cardiac muscle contraction	32/1123	98/7206	2.8291047438e-05
ko04610	Complement and coagulation cascades	1/1123	79/7206	3.31383802282e-05
ko05169	Epstein-Barr virus infection	13/1123	206/7206	5.62342791317e-05
ko05414	Dilated cardiomyopathy	34/1123	112/7206	6.39385219355e-05
ko04621	NOD-like receptor signaling pathway	8/1123	157/7206	7.73914551898e-05
ko04745	Phototransduction - fly	16/1123	38/7206	8.01829651968e-05
ko05110	Vibrio cholerae infection	22/1123	63/7206	0.000141863369487
ko04961	Endocrine and other factor-regulated calcium reabsorption	21/1123	59/7206	0.000168250190291
ko04014	Ras signaling pathway	67/1123	279/7206	0.000191188159473
ko03008	Ribosome biogenesis in eukaryotes	2/1123	79/7206	0.000269189587133
ko04141	Protein processing in endoplasmic reticulum	12/1123	184/7206	0.000272115402745
ko05205	Proteoglycans in cancer	22/1123	271/7206	0.00030710078271
ko04972	Pancreatic secretion	32/1123	111/7206	0.000317064392268
ko00604	Glycosphingolipid biosynthesis - ganglio series	8/1123	14/7206	0.000422539459969
ko04750	Inflammatory mediator regulation of TRP channels	34/1123	122/7206	0.00055614366245
ko05140	Leishmaniasis	2/1123	75/7206	0.000595191191095
ko04110	Cell cycle	9/1123	145/7206	0.000735823838175
ko05161	Hepatitis B	12/1123	173/7206	0.000900282421416
ko04064	NF-kappa B signaling pathway	4/1123	96/7206	0.000908728868944
ko04976	Bile secretion	24/1123	80/7206	0.000956187680523
ko05162	Measles	7/1123	120/7206	0.00141688851485
ko04146	Peroxisome	4/1123	89/7206	0.0017694066971
ko04072	Phospholipase D signaling pathway	47/1123	197/7206	0.00193918068581
ko04915	Estrogen signaling pathway	34/1123	131/7206	0.00212179531597
ko00480	Glutathione metabolism	1/1123	55/7206	0.00214560660035
ko04070	Phosphatidylinositol signaling system	30/1123	112/7206	0.00223031548132
ko04612	Antigen processing and presentation	3/1123	77/7206	0.00228591235976
ko04640	Hematopoietic cell lineage	2/1123	64/7206	0.0027683728297
ko00590	Arachidonic acid metabolism	1/1123	52/7206	0.00315635901634
ko04626	Plant-pathogen interaction	8/1123	18/7206	0.00343781015354
ko04371	Apelin signaling pathway	42/1123	177/7206	0.00434026001465
ko04214	Apoptosis - fly	3/1123	72/7206	0.00477429840109
ko04668	TNF signaling pathway	8/1123	120/7206	0.00484889888757
ko04932	Non-alcoholic fatty liver disease (NAFLD)	15/1123	182/7206	0.0048987934293
ko00240	Pyrimidine metabolism	7/1123	110/7206	0.00503071023891
ko00071	Fatty acid degradation	1/1123	45/7206	0.0068729620595
ko03420	Nucleotide excision repair	1/1123	46/7206	0.00690940566349
ko04923	Regulation of lipolysis in adipocytes	21/1123	77/7206	0.0070582941081
ko05410	Hypertrophic cardiomyopathy (HCM)	26/1123	100/7206	0.00759724956744
ko05321	Inflammatory bowel disease (IBD)	2/1123	56/7206	0.00862989302748
ko04964	Proximal tubule bicarbonate reclamation	10/1123	29/7206	0.00956850632869
ko03018	RNA degradation	5/1123	84/7206	0.0099414977474
ko01524	Platinum drug resistance	4/1123	76/7206	0.0100418413802
ko03022	Basal transcription factors	1/1123	44/7206	0.0105378512506
ko01200	Carbon metabolism	10/1123	128/7206	0.0132910068905
ko04622	RIG-I-like receptor signaling pathway	3/1123	62/7206	0.0135674343204
ko05131	Shigellosis	5/1123	82/7206	0.0136929228664
ko04916	Melanogenesis	33/1123	142/7206	0.0140367048717
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1123	40/7206	0.0152966534165
ko04912	GnRH signaling pathway	29/1123	122/7206	0.0162568566559
ko04620	Toll-like receptor signaling pathway	7/1123	100/7206	0.0172040282109
ko05145	Toxoplasmosis	10/1123	126/7206	0.0176917600772
ko04015	Rap1 signaling pathway	58/1123	278/7206	0.0178552585301
ko00380	Tryptophan metabolism	2/1123	50/7206	0.0180563108443
ko05418	Fluid shear stress and atherosclerosis	16/1123	173/7206	0.0191350980689
ko00330	Arginine and proline metabolism	3/1123	61/7206	0.019540650793
ko04630	Jak-STAT signaling pathway	11/1123	132/7206	0.0205936317877
ko04658	Th1 and Th2 cell differentiation	7/1123	96/7206	0.0225922175086
ko00982	Drug metabolism - cytochrome P450	1/1123	37/7206	0.0228136516501
ko00630	Glyoxylate and dicarboxylate metabolism	1/1123	38/7206	0.0229225519481
ko03410	Base excision repair	1/1123	38/7206	0.0229225519481
ko04657	IL-17 signaling pathway	6/1123	87/7206	0.024485792364
ko05133	Pertussis	6/1123	87/7206	0.024485792364
ko05166	HTLV-I infection	32/1123	292/7206	0.025907258001
ko00270	Cysteine and methionine metabolism	2/1123	47/7206	0.0260726598246
ko04270	Vascular smooth muscle contraction	34/1123	154/7206	0.0320893706118
ko00310	Lysine degradation	5/1123	73/7206	0.035002856632
ko04115	p53 signaling pathway	5/1123	74/7206	0.0351085155481
ko05144	Malaria	2/1123	45/7206	0.0376175228771
ko04140	Autophagy - animal	16/1123	164/7206	0.0380494988706
ko00280	Valine, leucine and isoleucine degradation	3/1123	54/7206	0.0380614103388
ko00620	Pyruvate metabolism	2/1123	46/7206	0.0384565634952
ko05222	Small cell lung cancer	7/1123	89/7206	0.0398811987859
ko05120	Epithelial cell signaling in Helicobacter pylori infection	22/1123	92/7206	0.0411182264973
ko05206	MicroRNAs in cancer	18/1123	177/7206	0.0457824407496