ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 40/306 191/7206 9.76908931151e-18 ko05164 Influenza A 34/306 167/7206 8.15445332712e-15 ko05340 Primary immunodeficiency 13/306 30/7206 7.08973144581e-11 ko04621 NOD-like receptor signaling pathway 27/306 157/7206 3.30202203407e-10 ko04658 Th1 and Th2 cell differentiation 21/306 96/7206 3.39165409875e-10 ko05168 Herpes simplex infection 28/306 182/7206 2.16686259501e-09 ko04380 Osteoclast differentiation 23/306 134/7206 7.43364971578e-09 ko05140 Leishmaniasis 17/306 75/7206 9.67163863525e-09 ko05145 Toxoplasmosis 22/306 126/7206 1.15021285902e-08 ko04672 Intestinal immune network for IgA production 12/306 37/7206 1.97821080184e-08 ko05162 Measles 21/306 120/7206 2.40109782164e-08 ko04217 Necroptosis 26/306 178/7206 2.53829238669e-08 ko04064 NF-kappa B signaling pathway 18/306 96/7206 8.25946065143e-08 ko05330 Allograft rejection 9/306 24/7206 2.97311718226e-07 ko04659 Th17 cell differentiation 18/306 106/7206 3.95822490449e-07 ko05321 Inflammatory bowel disease (IBD) 13/306 56/7206 4.11658435834e-07 ko04650 Natural killer cell mediated cytotoxicity 17/306 97/7206 5.25931717406e-07 ko04612 Antigen processing and presentation 15/306 77/7206 6.06319888695e-07 ko05320 Autoimmune thyroid disease 9/306 29/7206 1.88642592191e-06 ko04630 Jak-STAT signaling pathway 19/306 132/7206 2.57139401321e-06 ko05310 Asthma 7/306 17/7206 3.13258128427e-06 ko05152 Tuberculosis 23/306 187/7206 3.68149526046e-06 ko04062 Chemokine signaling pathway 24/306 201/7206 3.81443954229e-06 ko05332 Graft-versus-host disease 7/306 18/7206 4.94067464759e-06 ko05150 Staphylococcus aureus infection 9/306 36/7206 1.3630361129e-05 ko05160 Hepatitis C 19/306 153/7206 2.29176983262e-05 ko05161 Hepatitis B 20/306 173/7206 4.00983956919e-05 ko04623 Cytosolic DNA-sensing pathway 9/306 41/7206 4.20491415364e-05 ko04622 RIG-I-like receptor signaling pathway 11/306 62/7206 4.94290248631e-05 ko04666 Fc gamma R-mediated phagocytosis 16/306 122/7206 5.22827857331e-05 ko05167 Kaposi's sarcoma-associated herpesvirus infection 21/306 191/7206 5.4537172248e-05 ko04660 T cell receptor signaling pathway 16/306 124/7206 6.3889464978e-05 ko05323 Rheumatoid arthritis 13/306 89/7206 8.65043453885e-05 ko04611 Platelet activation 18/306 163/7206 0.000176215438678 ko00140 Steroid hormone biosynthesis 8/306 41/7206 0.000270456035838 ko00590 Arachidonic acid metabolism 9/306 52/7206 0.000292633359918 ko04940 Type I diabetes mellitus 7/306 32/7206 0.000312688363241 ko05416 Viral myocarditis 9/306 55/7206 0.000452204313075 ko04145 Phagosome 17/306 162/7206 0.000486910774497 ko04668 TNF signaling pathway 14/306 120/7206 0.000526981984217 ko04620 Toll-like receptor signaling pathway 12/306 100/7206 0.00101557958299 ko04657 IL-17 signaling pathway 11/306 87/7206 0.0010582256992 ko04640 Hematopoietic cell lineage 9/306 64/7206 0.00140128553264 ko04664 Fc epsilon RI signaling pathway 10/306 77/7206 0.00144139559228 ko04610 Complement and coagulation cascades 10/306 79/7206 0.00175656032053 ko04670 Leukocyte transendothelial migration 15/306 151/7206 0.00180689442293 ko04514 Cell adhesion molecules (CAMs) 13/306 130/7206 0.00338149117221 ko05133 Pertussis 10/306 87/7206 0.00361868927277 ko04933 AGE-RAGE signaling pathway in diabetic complications 13/306 135/7206 0.00738088509656 ko00051 Fructose and mannose metabolism 6/306 42/7206 0.00805668361302 ko00643 Styrene degradation 2/306 4/7206 0.0101883198475 ko05143 African trypanosomiasis 5/306 32/7206 0.0104749079657 ko00350 Tyrosine metabolism 5/306 33/7206 0.0119272682841 ko04662 B cell receptor signaling pathway 9/306 88/7206 0.0119832186536 ko05142 Chagas disease (American trypanosomiasis) 12/306 130/7206 0.0123586086303 ko05169 Epstein-Barr virus infection 16/306 206/7206 0.0203166739756 ko05131 Shigellosis 8/306 82/7206 0.0225177396382 ko02010 ABC transporters 5/306 39/7206 0.0235509174752 ko04210 Apoptosis 14/306 180/7206 0.0240263374719 ko04390 Hippo signaling pathway 2/306 188/7206 0.025477581331 ko04071 Sphingolipid signaling pathway 13/306 162/7206 0.0268731258004 ko05231 Choline metabolism in cancer 11/306 134/7206 0.0296440818609 ko04917 Prolactin signaling pathway 8/306 87/7206 0.0308276417606 ko04310 Wnt signaling pathway 2/306 181/7206 0.0365996864278 ko05144 Malaria 5/306 45/7206 0.0407402138914 ko00592 alpha-Linolenic acid metabolism 3/306 19/7206 0.0443800535976 ko00190 Oxidative phosphorylation 1/306 127/7206 0.0447253335493 ko01200 Carbon metabolism 1/306 128/7206 0.0447934554158 ko04080 Neuroactive ligand-receptor interaction 10/306 423/7206 0.0463981999979 ko05034 Alcoholism 4/306 238/7206 0.0477735367418 ko04550 Signaling pathways regulating pluripotency of stem cells 2/306 165/7206 0.0489000824139 ko04072 Phospholipase D signaling pathway 14/306 197/7206 0.0489948726787