ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	211/1243	423/7206	1.43398191915e-57
ko04724	Glutamatergic synapse	94/1243	152/7206	1.82533250142e-35
ko05033	Nicotine addiction	50/1243	56/7206	3.35268247871e-32
ko05032	Morphine addiction	74/1243	110/7206	1.17314251578e-31
ko04713	Circadian entrainment	82/1243	136/7206	6.65442757312e-30
ko04727	GABAergic synapse	70/1243	110/7206	9.84982766724e-28
ko04728	Dopaminergic synapse	92/1243	185/7206	8.11153073098e-25
ko04725	Cholinergic synapse	80/1243	160/7206	6.82703352535e-22
ko04721	Synaptic vesicle cycle	51/1243	80/7206	1.47788323336e-20
ko04723	Retrograde endocannabinoid signaling	82/1243	175/7206	4.09578484354e-20
ko04020	Calcium signaling pathway	107/1243	265/7206	1.02695319918e-19
ko04911	Insulin secretion	62/1243	117/7206	7.38273629423e-19
ko04024	cAMP signaling pathway	109/1243	279/7206	1.00140590562e-18
ko04726	Serotonergic synapse	66/1243	137/7206	3.51789577e-17
ko04744	Phototransduction	28/1243	36/7206	2.40241131916e-15
ko04921	Oxytocin signaling pathway	83/1243	209/7206	8.68664129044e-15
ko04742	Taste transduction	37/1243	61/7206	2.99054939058e-14
ko05031	Amphetamine addiction	47/1243	91/7206	4.87982411917e-14
ko04720	Long-term potentiation	48/1243	99/7206	5.7511529608e-13
ko04261	Adrenergic signaling in cardiomyocytes	77/1243	205/7206	1.68146755185e-12
ko04970	Salivary secretion	44/1243	95/7206	3.78353567885e-11
ko03040	Spliceosome	1/1243	145/7206	4.3285310114e-11
ko03010	Ribosome	1/1243	129/7206	9.27254383983e-10
ko05030	Cocaine addiction	35/1243	73/7206	1.20606712146e-09
ko04971	Gastric acid secretion	41/1243	98/7206	7.62687431329e-09
ko04925	Aldosterone synthesis and secretion	43/1243	105/7206	9.14865953615e-09
ko04360	Axon guidance	74/1243	233/7206	4.44562160785e-08
ko05322	Systemic lupus erythematosus	5/1243	151/7206	1.61658479871e-07
ko04060	Cytokine-cytokine receptor interaction	9/1243	191/7206	1.73992528766e-07
ko04070	Phosphatidylinositol signaling system	42/1243	112/7206	2.24105416747e-07
ko04740	Olfactory transduction	33/1243	80/7206	3.30733845471e-07
ko05203	Viral carcinogenesis	19/1243	277/7206	3.74274645488e-07
ko03013	RNA transport	7/1243	166/7206	3.79580994508e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	31/1243	74/7206	4.98630039885e-07
ko04022	cGMP-PKG signaling pathway	67/1243	216/7206	5.26762897055e-07
ko04961	Endocrine and other factor-regulated calcium reabsorption	26/1243	59/7206	1.29811081194e-06
ko04972	Pancreatic secretion	40/1243	111/7206	1.55220338279e-06
ko04010	MAPK signaling pathway	89/1243	321/7206	1.60388272563e-06
ko04730	Long-term depression	30/1243	78/7206	6.66563570939e-06
ko04141	Protein processing in endoplasmic reticulum	11/1243	184/7206	6.83180038346e-06
ko04072	Phospholipase D signaling pathway	59/1243	197/7206	8.43358173313e-06
ko04540	Gap junction	42/1243	128/7206	1.50409968952e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	29/1243	79/7206	3.07047616247e-05
ko05168	Herpes simplex infection	12/1243	182/7206	3.69136724716e-05
ko04711	Circadian rhythm - fly	9/1243	13/7206	4.83649384248e-05
ko05164	Influenza A	11/1243	167/7206	6.8766913212e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1243	79/7206	7.07518694713e-05
ko04745	Phototransduction - fly	17/1243	38/7206	7.12172725794e-05
ko04621	NOD-like receptor signaling pathway	10/1243	157/7206	9.78150157396e-05
ko04612	Antigen processing and presentation	2/1243	77/7206	0.000105937125238
ko05414	Dilated cardiomyopathy	36/1243	112/7206	0.000116568197573
ko04750	Inflammatory mediator regulation of TRP channels	38/1243	122/7206	0.000144076371933
ko05110	Vibrio cholerae infection	23/1243	63/7206	0.000278553678898
ko04976	Bile secretion	27/1243	80/7206	0.000286314912601
ko04110	Cell cycle	10/1243	145/7206	0.000343237907308
ko04514	Cell adhesion molecules (CAMs)	39/1243	130/7206	0.00036563581109
ko04260	Cardiac muscle contraction	31/1243	98/7206	0.00040281296067
ko04924	Renin secretion	28/1243	86/7206	0.000465555936468
ko04014	Ras signaling pathway	71/1243	279/7206	0.000472743427954
ko00520	Amino sugar and nucleotide sugar metabolism	1/1243	55/7206	0.000533998693861
ko04966	Collecting duct acid secretion	12/1243	26/7206	0.000588735960713
ko05169	Epstein-Barr virus infection	18/1243	206/7206	0.00068838626596
ko00590	Arachidonic acid metabolism	1/1243	52/7206	0.0012729700684
ko04915	Estrogen signaling pathway	37/1243	131/7206	0.00149948365784
ko04912	GnRH signaling pathway	35/1243	122/7206	0.0015182943306
ko04630	Jak-STAT signaling pathway	10/1243	132/7206	0.00161751453541
ko04710	Circadian rhythm	16/1243	43/7206	0.00167450764013
ko04610	Complement and coagulation cascades	4/1243	79/7206	0.00234290795431
ko03420	Nucleotide excision repair	1/1243	46/7206	0.00279442943365
ko05162	Measles	9/1243	120/7206	0.00315460029799
ko00240	Pyrimidine metabolism	8/1243	110/7206	0.00326145090998
ko04371	Apelin signaling pathway	46/1243	177/7206	0.00327462587509
ko00480	Glutathione metabolism	2/1243	55/7206	0.00370214707739
ko05321	Inflammatory bowel disease (IBD)	2/1243	56/7206	0.00377206829365
ko03022	Basal transcription factors	1/1243	44/7206	0.00424162336407
ko05144	Malaria	1/1243	45/7206	0.0044328532508
ko00071	Fatty acid degradation	1/1243	45/7206	0.0044328532508
ko04115	p53 signaling pathway	4/1243	74/7206	0.00473011823579
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1243	14/7206	0.00497247330739
ko05205	Proteoglycans in cancer	30/1243	271/7206	0.00518877702019
ko04923	Regulation of lipolysis in adipocytes	23/1243	77/7206	0.00577442073077
ko04918	Thyroid hormone synthesis	25/1243	86/7206	0.00592963886138
ko04120	Ubiquitin mediated proteolysis	12/1243	138/7206	0.00597631109992
ko04622	RIG-I-like receptor signaling pathway	3/1243	62/7206	0.00621482691068
ko04064	NF-kappa B signaling pathway	7/1243	96/7206	0.00633377868667
ko04626	Plant-pathogen interaction	8/1243	18/7206	0.00655542743773
ko04916	Melanogenesis	37/1243	142/7206	0.00696307813698
ko04932	Non-alcoholic fatty liver disease (NAFLD)	18/1243	182/7206	0.00699193013606
ko04015	Rap1 signaling pathway	65/1243	278/7206	0.00744394231155
ko05161	Hepatitis B	17/1243	173/7206	0.00778736907519
ko05202	Transcriptional misregulation in cancer	19/1243	188/7206	0.00794892120005
ko04217	Necroptosis	18/1243	178/7206	0.00883875527637
ko00562	Inositol phosphate metabolism	25/1243	89/7206	0.0103440889096
ko04964	Proximal tubule bicarbonate reclamation	11/1243	29/7206	0.0105289212803
ko05231	Choline metabolism in cancer	35/1243	134/7206	0.0105337796565
ko04960	Aldosterone-regulated sodium reabsorption	14/1243	41/7206	0.0106551648685
ko03018	RNA degradation	6/1243	84/7206	0.0125913358775
ko05140	Leishmaniasis	5/1243	75/7206	0.0129887433298
ko04062	Chemokine signaling pathway	48/1243	201/7206	0.0138168536374
ko03410	Base excision repair	1/1243	38/7206	0.0152464566266
ko05410	Hypertrophic cardiomyopathy (HCM)	27/1243	100/7206	0.0154889447381
ko04270	Vascular smooth muscle contraction	38/1243	154/7206	0.0173874747729
ko00280	Valine, leucine and isoleucine degradation	3/1243	54/7206	0.0180806461701
ko00310	Lysine degradation	5/1243	73/7206	0.0181720173195
ko04640	Hematopoietic cell lineage	4/1243	64/7206	0.0185470662427
ko04658	Th1 and Th2 cell differentiation	8/1243	96/7206	0.019829588299
ko04657	IL-17 signaling pathway	7/1243	87/7206	0.0214252223358
ko05133	Pertussis	7/1243	87/7206	0.0214252223358
ko00860	Porphyrin and chlorophyll metabolism	1/1243	34/7206	0.0215241664243
ko05166	HTLV-I infection	36/1243	292/7206	0.0217658339603
ko00500	Starch and sucrose metabolism	1/1243	35/7206	0.0220981026074
ko04973	Carbohydrate digestion and absorption	13/1243	42/7206	0.0242728852079
ko05418	Fluid shear stress and atherosclerosis	19/1243	173/7206	0.0249973909657
ko00330	Arginine and proline metabolism	4/1243	61/7206	0.0255624695147
ko04071	Sphingolipid signaling pathway	39/1243	162/7206	0.0265528231962
ko05016	Huntington's disease	25/1243	215/7206	0.0274474396075
ko04930	Type II diabetes mellitus	16/1243	54/7206	0.027651188954
ko04142	Lysosome	16/1243	151/7206	0.0289583007831
ko04114	Oocyte meiosis	34/1243	139/7206	0.0304687675368
ko00533	Glycosaminoglycan biosynthesis - keratan sulfate	6/1243	15/7206	0.0318551431554
ko00230	Purine metabolism	45/1243	194/7206	0.033476734268
ko04722	Neurotrophin signaling pathway	38/1243	160/7206	0.0337950835572
ko04146	Peroxisome	8/1243	89/7206	0.0344841785115
ko05222	Small cell lung cancer	8/1243	89/7206	0.0344841785115
ko00980	Metabolism of xenobiotics by cytochrome P450	2/1243	40/7206	0.0357092209803
ko00140	Steroid hormone biosynthesis	2/1243	41/7206	0.0360166202578
ko05131	Shigellosis	7/1243	82/7206	0.0383188859584
ko04214	Apoptosis - fly	6/1243	72/7206	0.0417179111857
ko05215	Prostate cancer	11/1243	111/7206	0.0419123435818
ko05145	Toxoplasmosis	13/1243	126/7206	0.0421832276902
ko04922	Glucagon signaling pathway	31/1243	128/7206	0.0439107599845
ko05034	Alcoholism	53/1243	238/7206	0.0443118747925
ko04210	Apoptosis	21/1243	180/7206	0.0454647207701
ko04350	TGF-beta signaling pathway	10/1243	103/7206	0.0475352278065
ko05340	Primary immunodeficiency	1/1243	30/7206	0.0489415602354