ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko05033	Nicotine addiction	44/923	56/7206	2.60385393116e-29
ko04080	Neuroactive ligand-receptor interaction	139/923	423/7206	1.03952214755e-28
ko04724	Glutamatergic synapse	74/923	152/7206	1.2734707546e-27
ko05032	Morphine addiction	60/923	110/7206	5.63290450569e-26
ko04727	GABAergic synapse	57/923	110/7206	3.12432351319e-23
ko04713	Circadian entrainment	64/923	136/7206	5.59191633663e-23
ko04728	Dopaminergic synapse	74/923	185/7206	3.97845417187e-21
ko04723	Retrograde endocannabinoid signaling	71/923	175/7206	9.97884694986e-21
ko04725	Cholinergic synapse	62/923	160/7206	4.67690200307e-17
ko04744	Phototransduction	25/923	36/7206	5.37447705552e-15
ko04721	Synaptic vesicle cycle	38/923	80/7206	2.7612384671e-14
ko04024	cAMP signaling pathway	82/923	279/7206	6.91266750115e-14
ko04921	Oxytocin signaling pathway	67/923	209/7206	1.46902832189e-13
ko04742	Taste transduction	31/923	61/7206	6.83404005287e-13
ko04726	Serotonergic synapse	49/923	137/7206	3.43194573253e-12
ko04911	Insulin secretion	43/923	117/7206	2.65976174226e-11
ko04261	Adrenergic signaling in cardiomyocytes	59/923	205/7206	7.91564600362e-10
ko04020	Calcium signaling pathway	70/923	265/7206	1.46891133821e-09
ko05031	Amphetamine addiction	34/923	91/7206	1.98802322643e-09
ko05203	Viral carcinogenesis	9/923	277/7206	3.68116978348e-08
ko04720	Long-term potentiation	33/923	99/7206	8.84295972083e-08
ko03040	Spliceosome	1/923	145/7206	9.38866922214e-08
ko04970	Salivary secretion	32/923	95/7206	1.05085282775e-07
ko04740	Olfactory transduction	27/923	80/7206	9.96327426139e-07
ko05164	Influenza A	4/923	167/7206	3.06044372211e-06
ko04060	Cytokine-cytokine receptor interaction	6/923	191/7206	4.80570429291e-06
ko05030	Cocaine addiction	24/923	73/7206	6.66614329021e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	24/923	74/7206	8.68930423379e-06
ko04010	MAPK signaling pathway	68/923	321/7206	1.67264659171e-05
ko03013	RNA transport	5/923	166/7206	1.69244964589e-05
ko05322	Systemic lupus erythematosus	4/923	151/7206	1.98164975746e-05
ko04925	Aldosterone synthesis and secretion	30/923	105/7206	2.06301828909e-05
ko04360	Axon guidance	53/923	233/7206	2.21348687516e-05
ko04022	cGMP-PKG signaling pathway	50/923	216/7206	2.72840393725e-05
ko04745	Phototransduction - fly	15/923	38/7206	3.21387693105e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	24/923	79/7206	4.84640295248e-05
ko04621	NOD-like receptor signaling pathway	5/923	157/7206	5.02701793934e-05
ko05168	Herpes simplex infection	7/923	182/7206	6.50386595409e-05
ko05169	Epstein-Barr virus infection	9/923	206/7206	7.26575707972e-05
ko04514	Cell adhesion molecules (CAMs)	33/923	130/7206	8.743798171e-05
ko04971	Gastric acid secretion	27/923	98/7206	8.74482924042e-05
ko04924	Renin secretion	24/923	86/7206	0.000141420280146
ko04260	Cardiac muscle contraction	26/923	98/7206	0.000198889720845
ko04730	Long-term depression	22/923	78/7206	0.000235257501841
ko04120	Ubiquitin mediated proteolysis	5/923	138/7206	0.000417308597077
ko03008	Ribosome biogenesis in eukaryotes	1/923	79/7206	0.00049868390866
ko05205	Proteoglycans in cancer	17/923	271/7206	0.000557357138985
ko05162	Measles	4/923	120/7206	0.000764364898849
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/923	14/7206	0.000837229043815
ko04214	Apoptosis - fly	1/923	72/7206	0.00108381505
ko04371	Apelin signaling pathway	38/923	177/7206	0.00126467124693
ko04014	Ras signaling pathway	54/923	279/7206	0.00176821772023
ko04064	NF-kappa B signaling pathway	3/923	96/7206	0.00183397605338
ko04972	Pancreatic secretion	26/923	111/7206	0.00223921252501
ko05414	Dilated cardiomyopathy	26/923	112/7206	0.00236225069845
ko04640	Hematopoietic cell lineage	1/923	64/7206	0.00237580032691
ko04612	Antigen processing and presentation	2/923	77/7206	0.00317800767167
ko04141	Protein processing in endoplasmic reticulum	11/923	184/7206	0.00343344267007
ko00330	Arginine and proline metabolism	1/923	61/7206	0.00352402374762
ko04966	Collecting duct acid secretion	9/923	26/7206	0.00364291868278
ko05161	Hepatitis B	10/923	173/7206	0.0036939912468
ko04146	Peroxisome	3/923	89/7206	0.00373211160702
ko05410	Hypertrophic cardiomyopathy (HCM)	23/923	100/7206	0.00396754466705
ko05140	Leishmaniasis	2/923	75/7206	0.00468122377654
ko05215	Prostate cancer	5/923	111/7206	0.00593247264108
ko04540	Gap junction	27/923	128/7206	0.00729799085989
ko00480	Glutathione metabolism	1/923	55/7206	0.00773871755212
ko04630	Jak-STAT signaling pathway	7/923	132/7206	0.00789143514707
ko05166	HTLV-I infection	23/923	292/7206	0.00924260980765
ko04070	Phosphatidylinositol signaling system	24/923	112/7206	0.00967358550259
ko04915	Estrogen signaling pathway	27/923	131/7206	0.0114377098947
ko00280	Valine, leucine and isoleucine degradation	1/923	54/7206	0.0120282585305
ko05010	Alzheimer's disease	38/923	202/7206	0.0135902628754
ko01524	Platinum drug resistance	3/923	76/7206	0.0150075981045
ko04657	IL-17 signaling pathway	4/923	87/7206	0.015360920453
ko04072	Phospholipase D signaling pathway	37/923	197/7206	0.0167470755963
ko04510	Focal adhesion	19/923	240/7206	0.018320110126
ko04668	TNF signaling pathway	7/923	120/7206	0.0185016694344
ko04750	Inflammatory mediator regulation of TRP channels	25/923	122/7206	0.0190343271629
ko04710	Circadian rhythm	11/923	43/7206	0.019725274887
ko04626	Plant-pathogen interaction	6/923	18/7206	0.0206231509972
ko03018	RNA degradation	4/923	84/7206	0.0211822443037
ko04930	Type II diabetes mellitus	13/923	54/7206	0.0218996577869
ko00071	Fatty acid degradation	1/923	45/7206	0.0249484558256
ko03420	Nucleotide excision repair	1/923	46/7206	0.0250297344689
ko04964	Proximal tubule bicarbonate reclamation	8/923	29/7206	0.0255484943164
ko00270	Cysteine and methionine metabolism	1/923	47/7206	0.0255741244435
ko00260	Glycine, serine and threonine metabolism	1/923	48/7206	0.0265849819138
ko04976	Bile secretion	17/923	80/7206	0.0286556941317
ko05016	Huntington's disease	17/923	215/7206	0.0290427969981
ko05145	Toxoplasmosis	8/923	126/7206	0.0301866401837
ko04110	Cell cycle	10/923	145/7206	0.0319374587858
ko00533	Glycosaminoglycan biosynthesis - keratan sulfate	5/923	15/7206	0.0339887104245
ko04142	Lysosome	11/923	151/7206	0.0366232988048
ko00983	Drug metabolism - other enzymes	1/923	42/7206	0.0366632583516
ko03022	Basal transcription factors	1/923	44/7206	0.0378473671353
ko04216	Ferroptosis	1/923	44/7206	0.0378473671353
ko05321	Inflammatory bowel disease (IBD)	2/923	56/7206	0.0415758698933
ko00240	Pyrimidine metabolism	7/923	110/7206	0.0430148815162
ko04961	Endocrine and other factor-regulated calcium reabsorption	13/923	59/7206	0.0472426747938
ko05146	Amoebiasis	6/923	99/7206	0.0473511093776
ko04810	Regulation of actin cytoskeleton	23/923	264/7206	0.0480901573414