ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	201/1243	423/7206	2.3765259646e-50
ko05033	Nicotine addiction	50/1243	56/7206	3.35268247871e-32
ko04724	Glutamatergic synapse	89/1243	152/7206	5.14051848972e-31
ko05032	Morphine addiction	72/1243	110/7206	1.16599143482e-29
ko04727	GABAergic synapse	68/1243	110/7206	7.09792069257e-26
ko04713	Circadian entrainment	75/1243	136/7206	5.17206105473e-24
ko04728	Dopaminergic synapse	86/1243	185/7206	9.21672359778e-21
ko04725	Cholinergic synapse	76/1243	160/7206	3.72599275387e-19
ko04723	Retrograde endocannabinoid signaling	80/1243	175/7206	7.87372305042e-19
ko04024	cAMP signaling pathway	109/1243	279/7206	1.00140590562e-18
ko04721	Synaptic vesicle cycle	48/1243	80/7206	7.781868137e-18
ko04742	Taste transduction	38/1243	61/7206	3.79795181167e-15
ko04020	Calcium signaling pathway	98/1243	265/7206	4.18508329215e-15
ko04744	Phototransduction	27/1243	36/7206	3.69637595293e-14
ko04911	Insulin secretion	55/1243	117/7206	5.97617325936e-14
ko04921	Oxytocin signaling pathway	79/1243	209/7206	5.94209448684e-13
ko04726	Serotonergic synapse	58/1243	137/7206	3.1764682601e-12
ko04360	Axon guidance	83/1243	233/7206	6.37651627392e-12
ko04261	Adrenergic signaling in cardiomyocytes	75/1243	205/7206	1.52233049662e-11
ko03040	Spliceosome	1/1243	145/7206	4.3285310114e-11
ko05031	Amphetamine addiction	41/1243	91/7206	5.09362183883e-10
ko05203	Viral carcinogenesis	15/1243	277/7206	3.07779401474e-09
ko04720	Long-term potentiation	41/1243	99/7206	1.71644508429e-08
ko05030	Cocaine addiction	33/1243	73/7206	2.2776046545e-08
ko05322	Systemic lupus erythematosus	4/1243	151/7206	2.29406635907e-08
ko04740	Olfactory transduction	35/1243	80/7206	2.42164393273e-08
ko05168	Herpes simplex infection	7/1243	182/7206	4.07530265587e-08
ko04970	Salivary secretion	39/1243	95/7206	4.67549554521e-08
ko03013	RNA transport	6/1243	166/7206	1.03023147079e-07
ko04971	Gastric acid secretion	38/1243	98/7206	4.605699296e-07
ko04925	Aldosterone synthesis and secretion	39/1243	105/7206	1.29444051144e-06
ko04010	MAPK signaling pathway	89/1243	321/7206	1.60388272563e-06
ko04060	Cytokine-cytokine receptor interaction	11/1243	191/7206	3.61551100027e-06
ko04022	cGMP-PKG signaling pathway	64/1243	216/7206	5.66986097985e-06
ko05164	Influenza A	9/1243	167/7206	6.14365777518e-06
ko04610	Complement and coagulation cascades	1/1243	79/7206	7.85810101002e-06
ko04961	Endocrine and other factor-regulated calcium reabsorption	24/1243	59/7206	1.7609703623e-05
ko04141	Protein processing in endoplasmic reticulum	12/1243	184/7206	2.63392939497e-05
ko04120	Ubiquitin mediated proteolysis	7/1243	138/7206	3.09156814979e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1243	74/7206	3.09443392823e-05
ko04924	Renin secretion	31/1243	86/7206	3.45596837191e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1243	79/7206	7.07518694713e-05
ko04745	Phototransduction - fly	17/1243	38/7206	7.12172725794e-05
ko05205	Proteoglycans in cancer	24/1243	271/7206	7.72029671428e-05
ko04972	Pancreatic secretion	36/1243	111/7206	0.000107503460541
ko04070	Phosphatidylinositol signaling system	36/1243	112/7206	0.000116568197573
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1243	79/7206	0.000117859239031
ko04514	Cell adhesion molecules (CAMs)	40/1243	130/7206	0.000141329667387
ko04730	Long-term depression	27/1243	78/7206	0.000207262275984
ko04621	NOD-like receptor signaling pathway	11/1243	157/7206	0.000245521032054
ko04260	Cardiac muscle contraction	31/1243	98/7206	0.00040281296067
ko04014	Ras signaling pathway	71/1243	279/7206	0.000472743427954
ko00480	Glutathione metabolism	1/1243	55/7206	0.000533998693861
ko04072	Phospholipase D signaling pathway	53/1243	197/7206	0.000540738480701
ko05414	Dilated cardiomyopathy	34/1243	112/7206	0.000567254317662
ko04064	NF-kappa B signaling pathway	5/1243	96/7206	0.00060216416281
ko04932	Non-alcoholic fatty liver disease (NAFLD)	15/1243	182/7206	0.000659172235365
ko04612	Antigen processing and presentation	3/1243	77/7206	0.000675281120696
ko05169	Epstein-Barr virus infection	18/1243	206/7206	0.00068838626596
ko04976	Bile secretion	26/1243	80/7206	0.000847137727728
ko04540	Gap junction	37/1243	128/7206	0.000878192974159
ko05162	Measles	8/1243	120/7206	0.000920999394325
ko05140	Leishmaniasis	3/1243	75/7206	0.00100002492466
ko04110	Cell cycle	11/1243	145/7206	0.00115003690028
ko04640	Hematopoietic cell lineage	2/1243	64/7206	0.00121814853781
ko00590	Arachidonic acid metabolism	1/1243	52/7206	0.0012729700684
ko04371	Apelin signaling pathway	47/1243	177/7206	0.00167159974241
ko04146	Peroxisome	5/1243	89/7206	0.00171340322152
ko00330	Arginine and proline metabolism	2/1243	61/7206	0.00174544724301
ko05110	Vibrio cholerae infection	21/1243	63/7206	0.00203606432796
ko04923	Regulation of lipolysis in adipocytes	24/1243	77/7206	0.00225855621721
ko04966	Collecting duct acid secretion	11/1243	26/7206	0.00237420990604
ko04658	Th1 and Th2 cell differentiation	6/1243	96/7206	0.00248093087015
ko03420	Nucleotide excision repair	1/1243	46/7206	0.00279442943365
ko04915	Estrogen signaling pathway	36/1243	131/7206	0.00325482113388
ko00240	Pyrimidine metabolism	8/1243	110/7206	0.00326145090998
ko03018	RNA degradation	5/1243	84/7206	0.00339734904692
ko04750	Inflammatory mediator regulation of TRP channels	34/1243	122/7206	0.00340149659525
ko05321	Inflammatory bowel disease (IBD)	2/1243	56/7206	0.00377206829365
ko05161	Hepatitis B	16/1243	173/7206	0.00409293927134
ko03022	Basal transcription factors	1/1243	44/7206	0.00424162336407
ko05144	Malaria	1/1243	45/7206	0.0044328532508
ko05131	Shigellosis	5/1243	82/7206	0.00477757426682
ko04630	Jak-STAT signaling pathway	11/1243	132/7206	0.00492789226065
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1243	14/7206	0.00497247330739
ko04622	RIG-I-like receptor signaling pathway	3/1243	62/7206	0.00621482691068
ko04214	Apoptosis - fly	4/1243	72/7206	0.00681758557755
ko00380	Tryptophan metabolism	2/1243	50/7206	0.00797514978725
ko04140	Autophagy - animal	16/1243	164/7206	0.00867715652015
ko04217	Necroptosis	18/1243	178/7206	0.00883875527637
ko04210	Apoptosis	18/1243	180/7206	0.00900444787392
ko04657	IL-17 signaling pathway	6/1243	87/7206	0.00932804214911
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1243	40/7206	0.00991673108084
ko04964	Proximal tubule bicarbonate reclamation	11/1243	29/7206	0.0105289212803
ko04620	Toll-like receptor signaling pathway	8/1243	100/7206	0.0109501547599
ko00260	Glycine, serine and threonine metabolism	2/1243	48/7206	0.0116843029036
ko05219	Bladder cancer	2/1243	48/7206	0.0116843029036
ko04115	p53 signaling pathway	5/1243	74/7206	0.0128292834897
ko00982	Drug metabolism - cytochrome P450	1/1243	37/7206	0.0145219779455
ko05410	Hypertrophic cardiomyopathy (HCM)	27/1243	100/7206	0.0154889447381
ko00071	Fatty acid degradation	2/1243	45/7206	0.0169906537112
ko00620	Pyruvate metabolism	2/1243	46/7206	0.0171732698976
ko00280	Valine, leucine and isoleucine degradation	3/1243	54/7206	0.0180806461701
ko04015	Rap1 signaling pathway	63/1243	278/7206	0.0186128331071
ko05133	Pertussis	7/1243	87/7206	0.0214252223358
ko00640	Propanoate metabolism	1/1243	34/7206	0.0215241664243
ko05215	Prostate cancer	10/1243	111/7206	0.0217397138784
ko05166	HTLV-I infection	36/1243	292/7206	0.0217658339603
ko04626	Plant-pathogen interaction	7/1243	18/7206	0.0244837364617
ko05418	Fluid shear stress and atherosclerosis	19/1243	173/7206	0.0249973909657
ko04142	Lysosome	16/1243	151/7206	0.0289583007831
ko04270	Vascular smooth muscle contraction	37/1243	154/7206	0.0304994662315
ko01524	Platinum drug resistance	6/1243	76/7206	0.0312898884018
ko04136	Autophagy - other	1/1243	31/7206	0.0322231256032
ko00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	9/1243	26/7206	0.0322926336421
ko01200	Carbon metabolism	13/1243	128/7206	0.0329500471061
ko00140	Steroid hormone biosynthesis	2/1243	41/7206	0.0360166202578
ko04668	TNF signaling pathway	12/1243	120/7206	0.0373664303471
ko04137	Mitophagy - animal	7/1243	82/7206	0.0383188859584
ko00310	Lysine degradation	6/1243	73/7206	0.0418480471509
ko05145	Toxoplasmosis	13/1243	126/7206	0.0421832276902
ko05134	Legionellosis	6/1243	74/7206	0.0425691385489
ko04918	Thyroid hormone synthesis	22/1243	86/7206	0.0445484705382
ko05320	Autoimmune thyroid disease	1/1243	29/7206	0.0479719119444