ko pathway ratio_in_study ratio_in_pop p_value ko05340 Primary immunodeficiency 14/232 30/7206 8.01798570002e-14 ko04060 Cytokine-cytokine receptor interaction 29/232 191/7206 1.66500320478e-12 ko04650 Natural killer cell mediated cytotoxicity 19/232 97/7206 1.59949690152e-10 ko04612 Antigen processing and presentation 17/232 77/7206 2.10436792975e-10 ko05140 Leishmaniasis 16/232 75/7206 1.25504564427e-09 ko05330 Allograft rejection 10/232 24/7206 1.30301050758e-09 ko05164 Influenza A 23/232 167/7206 2.79633470863e-09 ko05152 Tuberculosis 24/232 187/7206 5.2603099008e-09 ko04659 Th17 cell differentiation 18/232 106/7206 5.5555292459e-09 ko05162 Measles 19/232 120/7206 6.90839139531e-09 ko05320 Autoimmune thyroid disease 10/232 29/7206 1.15463804337e-08 ko05145 Toxoplasmosis 19/232 126/7206 1.58485620101e-08 ko05332 Graft-versus-host disease 8/232 18/7206 3.39164328183e-08 ko05321 Inflammatory bowel disease (IBD) 12/232 56/7206 1.48684366035e-07 ko05168 Herpes simplex infection 21/232 182/7206 3.19797448181e-07 ko04621 NOD-like receptor signaling pathway 19/232 157/7206 5.70433288033e-07 ko04217 Necroptosis 20/232 178/7206 9.49972297352e-07 ko04660 T cell receptor signaling pathway 16/232 124/7206 1.95323333637e-06 ko04658 Th1 and Th2 cell differentiation 14/232 96/7206 1.98769187321e-06 ko04620 Toll-like receptor signaling pathway 14/232 100/7206 3.27301056097e-06 ko04380 Osteoclast differentiation 16/232 134/7206 5.48452751371e-06 ko04940 Type I diabetes mellitus 8/232 32/7206 5.51370100768e-06 ko03050 Proteasome 10/232 54/7206 6.79430473078e-06 ko05144 Malaria 9/232 45/7206 1.02523679572e-05 ko05150 Staphylococcus aureus infection 8/232 36/7206 1.41893001373e-05 ko04145 Phagosome 17/232 162/7206 1.6040459755e-05 ko05133 Pertussis 12/232 87/7206 1.95095332558e-05 ko04630 Jak-STAT signaling pathway 14/232 132/7206 8.11807986203e-05 ko05310 Asthma 5/232 17/7206 0.000149300635963 ko04640 Hematopoietic cell lineage 9/232 64/7206 0.000187073292636 ko04062 Chemokine signaling pathway 17/232 201/7206 0.000243765085183 ko04622 RIG-I-like receptor signaling pathway 8/232 62/7206 0.000770763518245 ko05142 Chagas disease (American trypanosomiasis) 12/232 130/7206 0.000934830009574 ko04064 NF-kappa B signaling pathway 10/232 96/7206 0.000981419795746 ko04672 Intestinal immune network for IgA production 6/232 37/7206 0.00105023223359 ko05416 Viral myocarditis 7/232 55/7206 0.00178009813811 ko05323 Rheumatoid arthritis 9/232 89/7206 0.00215123203281 ko04514 Cell adhesion molecules (CAMs) 11/232 130/7206 0.00303343217574 ko05161 Hepatitis B 13/232 173/7206 0.00374374026186 ko04144 Endocytosis 21/232 342/7206 0.00410681760941 ko05167 Kaposi's sarcoma-associated herpesvirus infection 14/232 191/7206 0.00511151952413 ko04666 Fc gamma R-mediated phagocytosis 10/232 122/7206 0.00579918501395 ko04360 Axon guidance 1/232 233/7206 0.00724506936583 ko04664 Fc epsilon RI signaling pathway 7/232 77/7206 0.011629457915 ko04610 Complement and coagulation cascades 7/232 79/7206 0.013283911383 ko05132 Salmonella infection 8/232 98/7206 0.0133637206838 ko05146 Amoebiasis 8/232 99/7206 0.0141482060017 ko05016 Huntington's disease 1/232 215/7206 0.0159892070773 ko05160 Hepatitis C 11/232 153/7206 0.0165570360328 ko05143 African trypanosomiasis 4/232 32/7206 0.0185567890531 ko04662 B cell receptor signaling pathway 7/232 88/7206 0.0228539102652 ko05010 Alzheimer's disease 1/232 202/7206 0.0229366066538 ko00120 Primary bile acid biosynthesis 3/232 20/7206 0.0250562032608 ko00590 Arachidonic acid metabolism 5/232 52/7206 0.0251959552997 ko04142 Lysosome 10/232 151/7206 0.0303653836232 ko04310 Wnt signaling pathway 1/232 181/7206 0.0315098122351 ko04728 Dopaminergic synapse 1/232 185/7206 0.0319293588241 ko04611 Platelet activation 10/232 163/7206 0.0418017426852 ko04623 Cytosolic DNA-sensing pathway 4/232 41/7206 0.041820307317 ko04910 Insulin signaling pathway 1/232 172/7206 0.0457681460095 ko05224 Breast cancer 1/232 174/7206 0.0462762850254 ko04723 Retrograde endocannabinoid signaling 1/232 175/7206 0.0465934189152 ko05206 MicroRNAs in cancer 1/232 177/7206 0.0473533825438 ko05131 Shigellosis 6/232 82/7206 0.0480900088257 ko04020 Calcium signaling pathway 3/232 265/7206 0.0493723019811