ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	207/1247	423/7206	2.24574283686e-54
ko04724	Glutamatergic synapse	90/1247	152/7206	9.07625941287e-32
ko04713	Circadian entrainment	82/1247	136/7206	8.43087837931e-30
ko05033	Nicotine addiction	47/1247	56/7206	1.13939235747e-27
ko05032	Morphine addiction	69/1247	110/7206	1.04248299025e-26
ko04727	GABAergic synapse	65/1247	110/7206	3.90241200687e-23
ko04020	Calcium signaling pathway	111/1247	265/7206	8.19170993287e-22
ko04728	Dopaminergic synapse	87/1247	185/7206	2.5733318408e-21
ko04721	Synaptic vesicle cycle	51/1247	80/7206	1.71402433198e-20
ko04725	Cholinergic synapse	77/1247	160/7206	9.7879601369e-20
ko04024	cAMP signaling pathway	109/1247	279/7206	1.22507325821e-18
ko04723	Retrograde endocannabinoid signaling	78/1247	175/7206	1.67213821468e-17
ko04921	Oxytocin signaling pathway	86/1247	209/7206	1.53488290441e-16
ko04742	Taste transduction	39/1247	61/7206	5.04026069372e-16
ko04911	Insulin secretion	58/1247	117/7206	6.74509402907e-16
ko04726	Serotonergic synapse	62/1247	137/7206	1.56761185187e-14
ko04970	Salivary secretion	47/1247	95/7206	4.41176962452e-13
ko04261	Adrenergic signaling in cardiomyocytes	76/1247	205/7206	6.70320221162e-12
ko04720	Long-term potentiation	46/1247	99/7206	1.31975128574e-11
ko05031	Amphetamine addiction	43/1247	91/7206	3.09918389887e-11
ko04022	cGMP-PKG signaling pathway	75/1247	216/7206	3.64675100033e-10
ko03040	Spliceosome	2/1247	145/7206	6.02004321364e-10
ko04360	Axon guidance	78/1247	233/7206	1.06462338587e-09
ko04740	Olfactory transduction	36/1247	80/7206	6.64415220879e-09
ko04971	Gastric acid secretion	41/1247	98/7206	8.40316494689e-09
ko04925	Aldosterone synthesis and secretion	43/1247	105/7206	9.76893960007e-09
ko04744	Phototransduction	21/1247	36/7206	3.3957905587e-08
ko05203	Viral carcinogenesis	17/1247	277/7206	3.76164498608e-08
ko04540	Gap junction	48/1247	128/7206	4.0533734191e-08
ko04060	Cytokine-cytokine receptor interaction	9/1247	191/7206	1.72405696589e-07
ko04924	Renin secretion	35/1247	86/7206	3.07184269303e-07
ko03013	RNA transport	7/1247	166/7206	3.78128518179e-07
ko05030	Cocaine addiction	30/1247	73/7206	2.20938680976e-06
ko05168	Herpes simplex infection	10/1247	182/7206	2.31070053614e-06
ko04730	Long-term depression	31/1247	78/7206	2.43811589239e-06
ko05322	Systemic lupus erythematosus	7/1247	151/7206	3.44577437761e-06
ko04621	NOD-like receptor signaling pathway	8/1247	157/7206	5.57903591603e-06
ko05164	Influenza A	9/1247	167/7206	6.16621096637e-06
ko04972	Pancreatic secretion	38/1247	111/7206	1.23494563306e-05
ko04010	MAPK signaling pathway	86/1247	321/7206	1.45850707506e-05
ko04976	Bile secretion	30/1247	80/7206	1.62973414806e-05
ko04120	Ubiquitin mediated proteolysis	7/1247	138/7206	2.09196749877e-05
ko04966	Collecting duct acid secretion	14/1247	26/7206	2.44644450861e-05
ko04141	Protein processing in endoplasmic reticulum	12/1247	184/7206	2.66663774501e-05
ko05110	Vibrio cholerae infection	25/1247	63/7206	2.68381137197e-05
ko04514	Cell adhesion molecules (CAMs)	42/1247	130/7206	3.00045058977e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1247	74/7206	3.15396098522e-05
ko04070	Phosphatidylinositol signaling system	37/1247	112/7206	4.22448734077e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1247	79/7206	7.03645479575e-05
ko04371	Apelin signaling pathway	52/1247	177/7206	7.1217904584e-05
ko04745	Phototransduction - fly	17/1247	38/7206	7.42734844279e-05
ko04961	Endocrine and other factor-regulated calcium reabsorption	23/1247	59/7206	7.46360492731e-05
ko04750	Inflammatory mediator regulation of TRP channels	39/1247	122/7206	8.38718690076e-05
ko05169	Epstein-Barr virus infection	16/1247	206/7206	0.000109361767317
ko05414	Dilated cardiomyopathy	36/1247	112/7206	0.000120126408701
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1247	79/7206	0.000120214256989
ko05140	Leishmaniasis	2/1247	75/7206	0.000159990041843
ko04064	NF-kappa B signaling pathway	4/1247	96/7206	0.000183197321185
ko04260	Cardiac muscle contraction	32/1247	98/7206	0.000213191911365
ko04110	Cell cycle	10/1247	145/7206	0.000341869375865
ko04072	Phospholipase D signaling pathway	54/1247	197/7206	0.000364947716313
ko04923	Regulation of lipolysis in adipocytes	26/1247	77/7206	0.000395883526878
ko04610	Complement and coagulation cascades	3/1247	79/7206	0.000458035812871
ko04964	Proximal tubule bicarbonate reclamation	13/1247	29/7206	0.000511662288649
ko04146	Peroxisome	4/1247	89/7206	0.0005628343421
ko05205	Proteoglycans in cancer	27/1247	271/7206	0.000745783247702
ko04014	Ras signaling pathway	70/1247	279/7206	0.000878400283109
ko05162	Measles	8/1247	120/7206	0.000917523449821
ko00240	Pyrimidine metabolism	7/1247	110/7206	0.00130157437322
ko04932	Non-alcoholic fatty liver disease (NAFLD)	16/1247	182/7206	0.0013888497293
ko05161	Hepatitis B	15/1247	173/7206	0.00151062425593
ko04915	Estrogen signaling pathway	37/1247	131/7206	0.00154614601479
ko04612	Antigen processing and presentation	4/1247	77/7206	0.002285468822
ko04657	IL-17 signaling pathway	5/1247	87/7206	0.00242831769211
ko03420	Nucleotide excision repair	1/1247	46/7206	0.00278945312178
ko01524	Platinum drug resistance	4/1247	76/7206	0.00329716844355
ko03018	RNA degradation	5/1247	84/7206	0.00339113339886
ko04270	Vascular smooth muscle contraction	41/1247	154/7206	0.00342574047335
ko00480	Glutathione metabolism	2/1247	55/7206	0.00369408995105
ko05321	Inflammatory bowel disease (IBD)	2/1247	56/7206	0.0037872511414
ko03022	Basal transcription factors	1/1247	44/7206	0.00424476716016
ko00071	Fatty acid degradation	1/1247	45/7206	0.00446291680891
ko04214	Apoptosis - fly	4/1247	72/7206	0.00462820275651
ko05131	Shigellosis	5/1247	82/7206	0.00478371703081
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1247	14/7206	0.00506593881621
ko00590	Arachidonic acid metabolism	2/1247	52/7206	0.00543722636682
ko04622	RIG-I-like receptor signaling pathway	3/1247	62/7206	0.00622252112495
ko05133	Pertussis	6/1247	87/7206	0.00654509038111
ko04626	Plant-pathogen interaction	8/1247	18/7206	0.00668850713474
ko05410	Hypertrophic cardiomyopathy (HCM)	28/1247	100/7206	0.00725773964669
ko05215	Prostate cancer	9/1247	111/7206	0.00758105083494
ko05418	Fluid shear stress and atherosclerosis	17/1247	173/7206	0.00782172596464
ko05145	Toxoplasmosis	11/1247	126/7206	0.00856017139593
ko04217	Necroptosis	18/1247	178/7206	0.00883280918671
ko04916	Melanogenesis	37/1247	142/7206	0.00945900330135
ko04630	Jak-STAT signaling pathway	12/1247	132/7206	0.0102176619398
ko04620	Toll-like receptor signaling pathway	8/1247	100/7206	0.010942970266
ko04912	GnRH signaling pathway	32/1247	122/7206	0.0111682017621
ko00260	Glycine, serine and threonine metabolism	2/1247	48/7206	0.0116835782599
ko04115	p53 signaling pathway	5/1247	74/7206	0.0128155642674
ko04922	Glucagon signaling pathway	33/1247	128/7206	0.0132491652993
ko04918	Thyroid hormone synthesis	24/1247	86/7206	0.013896593487
ko04668	TNF signaling pathway	11/1247	120/7206	0.0147220810906
ko04711	Circadian rhythm - fly	6/1247	13/7206	0.0151028032613
ko05222	Small cell lung cancer	7/1247	89/7206	0.0158365925977
ko04210	Apoptosis	19/1247	180/7206	0.016126993299
ko05144	Malaria	2/1247	45/7206	0.0169503533241
ko01200	Carbon metabolism	12/1247	128/7206	0.0176274765839
ko04330	Notch signaling pathway	4/1247	62/7206	0.0181991421855
ko00310	Lysine degradation	5/1247	73/7206	0.0182749911645
ko04640	Hematopoietic cell lineage	4/1247	64/7206	0.0186246890687
ko04658	Th1 and Th2 cell differentiation	8/1247	96/7206	0.0199149053766
ko05166	HTLV-I infection	36/1247	292/7206	0.0217618147583
ko03320	PPAR signaling pathway	5/1247	69/7206	0.0243357125322
ko00330	Arginine and proline metabolism	4/1247	61/7206	0.0256121341242
ko04930	Type II diabetes mellitus	16/1247	54/7206	0.0278796347594
ko04015	Rap1 signaling pathway	62/1247	278/7206	0.0287978766759
ko04114	Oocyte meiosis	34/1247	139/7206	0.0308119741276
ko05132	Salmonella infection	9/1247	98/7206	0.0310129039917
ko00980	Metabolism of xenobiotics by cytochrome P450	2/1247	40/7206	0.0356356825554
ko00380	Tryptophan metabolism	3/1247	50/7206	0.0368151823553
ko04710	Circadian rhythm	13/1247	43/7206	0.0398129598647
ko00600	Sphingolipid metabolism	5/1247	63/7206	0.0453319414607
ko00562	Inositol phosphate metabolism	23/1247	89/7206	0.0467552584349
ko04350	TGF-beta signaling pathway	10/1247	103/7206	0.0477293049617
ko05320	Autoimmune thyroid disease	1/1247	29/7206	0.047921980121
ko05340	Primary immunodeficiency	1/1247	30/7206	0.0490441583041
ko04142	Lysosome	17/1247	151/7206	0.0498514579921