ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 43/395 191/7206 4.85218732456e-16 ko04650 Natural killer cell mediated cytotoxicity 26/395 97/7206 5.56523356818e-12 ko04380 Osteoclast differentiation 29/395 134/7206 1.00079219231e-10 ko05340 Primary immunodeficiency 14/395 30/7206 1.1468014776e-10 ko05164 Influenza A 32/395 167/7206 2.98914451342e-10 ko05162 Measles 25/395 120/7206 4.71397980374e-09 ko04659 Th17 cell differentiation 23/395 106/7206 8.70565289087e-09 ko05140 Leishmaniasis 19/395 75/7206 1.19315044239e-08 ko05145 Toxoplasmosis 25/395 126/7206 1.34894980565e-08 ko04660 T cell receptor signaling pathway 24/395 124/7206 4.39277392321e-08 ko05152 Tuberculosis 30/395 187/7206 8.04289152889e-08 ko04621 NOD-like receptor signaling pathway 27/395 157/7206 8.42871520677e-08 ko04064 NF-kappa B signaling pathway 20/395 96/7206 1.69623793273e-07 ko05321 Inflammatory bowel disease (IBD) 15/395 56/7206 1.90936393661e-07 ko05330 Allograft rejection 10/395 24/7206 2.14718781724e-07 ko04612 Antigen processing and presentation 17/395 77/7206 6.07176210846e-07 ko04658 Th1 and Th2 cell differentiation 19/395 96/7206 8.0210590954e-07 ko05320 Autoimmune thyroid disease 10/395 29/7206 1.71128788439e-06 ko05332 Graft-versus-host disease 8/395 18/7206 2.04557990233e-06 ko04672 Intestinal immune network for IgA production 11/395 37/7206 2.73935982773e-06 ko04217 Necroptosis 26/395 178/7206 3.75819408567e-06 ko05168 Herpes simplex infection 26/395 182/7206 5.70875016762e-06 ko04630 Jak-STAT signaling pathway 21/395 132/7206 8.53934851572e-06 ko04062 Chemokine signaling pathway 27/395 201/7206 1.2140015958e-05 ko05167 Kaposi's sarcoma-associated herpesvirus infection 26/395 191/7206 1.38794135002e-05 ko05150 Staphylococcus aureus infection 10/395 36/7206 1.53590534257e-05 ko04662 B cell receptor signaling pathway 16/395 88/7206 1.86242218181e-05 ko04610 Complement and coagulation cascades 15/395 79/7206 1.98209270054e-05 ko05142 Chagas disease (American trypanosomiasis) 20/395 130/7206 2.32789388082e-05 ko04620 Toll-like receptor signaling pathway 17/395 100/7206 2.56570865907e-05 ko05144 Malaria 10/395 45/7206 0.000123664651968 ko04640 Hematopoietic cell lineage 12/395 64/7206 0.000152211908923 ko05161 Hepatitis B 22/395 173/7206 0.000229189362654 ko04940 Type I diabetes mellitus 8/395 32/7206 0.000249300802441 ko05323 Rheumatoid arthritis 14/395 89/7206 0.000308259550893 ko00120 Primary bile acid biosynthesis 6/395 20/7206 0.00052435514445 ko04145 Phagosome 20/395 162/7206 0.000611292357668 ko04611 Platelet activation 20/395 163/7206 0.000648806214126 ko05133 Pertussis 13/395 87/7206 0.000831381524308 ko05034 Alcoholism 3/395 238/7206 0.00125679113028 ko03013 RNA transport 1/395 166/7206 0.00154311252689 ko05310 Asthma 5/395 17/7206 0.0017245603642 ko04622 RIG-I-like receptor signaling pathway 10/395 62/7206 0.00181106293284 ko03050 Proteasome 9/395 54/7206 0.00240519302295 ko00592 alpha-Linolenic acid metabolism 5/395 19/7206 0.00295932264897 ko04664 Fc epsilon RI signaling pathway 11/395 77/7206 0.00296183824708 ko04666 Fc gamma R-mediated phagocytosis 15/395 122/7206 0.00358566274658 ko03040 Spliceosome 1/395 145/7206 0.00482211309614 ko04137 Mitophagy - animal 11/395 82/7206 0.00485888957841 ko04670 Leukocyte transendothelial migration 17/395 151/7206 0.0054156366563 ko05160 Hepatitis C 17/395 153/7206 0.00576083169155 ko00590 Arachidonic acid metabolism 8/395 52/7206 0.0068352622934 ko04668 TNF signaling pathway 14/395 120/7206 0.00685614456605 ko04146 Peroxisome 11/395 89/7206 0.00900383766027 ko03010 Ribosome 1/395 129/7206 0.010080558292 ko04080 Neuroactive ligand-receptor interaction 12/395 423/7206 0.0110035989958 ko05146 Amoebiasis 12/395 99/7206 0.0112175612074 ko04210 Apoptosis 18/395 180/7206 0.0119142486373 ko04390 Hippo signaling pathway 3/395 188/7206 0.0136095656558 ko04514 Cell adhesion molecules (CAMs) 14/395 130/7206 0.0168070509786 ko04360 Axon guidance 5/395 233/7206 0.018490378967 ko04310 Wnt signaling pathway 3/395 181/7206 0.0189454537184 ko00980 Metabolism of xenobiotics by cytochrome P450 6/395 40/7206 0.0205869192922 ko05132 Salmonella infection 11/395 98/7206 0.0216715698777 ko00140 Steroid hormone biosynthesis 6/395 41/7206 0.023039764133 ko04623 Cytosolic DNA-sensing pathway 6/395 41/7206 0.023039764133 ko04916 Melanogenesis 2/395 142/7206 0.0244028160544 ko04068 FoxO signaling pathway 16/395 167/7206 0.0247936399746 ko04530 Tight junction 5/395 228/7206 0.0251418996193 ko00051 Fructose and mannose metabolism 6/395 42/7206 0.0256816170527 ko05224 Breast cancer 3/395 174/7206 0.026290355615 ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis 2/395 5/7206 0.0268364649461 ko05169 Epstein-Barr virus infection 19/395 206/7206 0.0276348613014 ko05416 Viral myocarditis 7/395 55/7206 0.0294904180154 ko05131 Shigellosis 9/395 82/7206 0.0442342815451 ko05204 Chemical carcinogenesis 6/395 48/7206 0.0457583691141 ko00982 Drug metabolism - cytochrome P450 5/395 37/7206 0.0496166038554