ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 40/368 191/7206 6.56492996501e-15 ko05340 Primary immunodeficiency 14/368 30/7206 4.43586679908e-11 ko04380 Osteoclast differentiation 28/368 134/7206 9.69130248533e-11 ko04621 NOD-like receptor signaling pathway 29/368 157/7206 9.88897826591e-10 ko04650 Natural killer cell mediated cytotoxicity 22/368 97/7206 2.0651380231e-09 ko05140 Leishmaniasis 19/368 75/7206 3.70642370724e-09 ko05164 Influenza A 29/368 167/7206 4.40924647553e-09 ko05145 Toxoplasmosis 24/368 126/7206 1.5448527013e-08 ko05162 Measles 23/368 120/7206 2.74766557366e-08 ko05152 Tuberculosis 29/368 187/7206 6.1066884004e-08 ko05321 Inflammatory bowel disease (IBD) 15/368 56/7206 7.52230706466e-08 ko04612 Antigen processing and presentation 17/368 77/7206 2.21642542009e-07 ko04064 NF-kappa B signaling pathway 19/368 96/7206 2.69292208124e-07 ko04659 Th17 cell differentiation 20/368 106/7206 2.95783486391e-07 ko04660 T cell receptor signaling pathway 21/368 124/7206 9.82058160477e-07 ko04062 Chemokine signaling pathway 28/368 201/7206 1.01163496832e-06 ko04672 Intestinal immune network for IgA production 11/368 37/7206 1.36558384051e-06 ko04610 Complement and coagulation cascades 16/368 79/7206 1.73578875309e-06 ko05168 Herpes simplex infection 25/368 182/7206 5.04781288621e-06 ko04658 Th1 and Th2 cell differentiation 17/368 96/7206 5.76019309753e-06 ko05150 Staphylococcus aureus infection 10/368 36/7206 8.22591240793e-06 ko05320 Autoimmune thyroid disease 9/368 29/7206 8.62704874834e-06 ko04620 Toll-like receptor signaling pathway 17/368 100/7206 1.01850264223e-05 ko04630 Jak-STAT signaling pathway 20/368 132/7206 1.0381776645e-05 ko04217 Necroptosis 24/368 178/7206 1.08165895913e-05 ko05167 Kaposi's sarcoma-associated herpesvirus infection 25/368 191/7206 1.20052134968e-05 ko05330 Allograft rejection 8/368 24/7206 1.53242463339e-05 ko04662 B cell receptor signaling pathway 15/368 88/7206 3.27848606641e-05 ko04145 Phagosome 21/368 162/7206 6.96187434257e-05 ko04640 Hematopoietic cell lineage 12/368 64/7206 7.74269431494e-05 ko05332 Graft-versus-host disease 6/368 18/7206 0.000187164108594 ko05161 Hepatitis B 21/368 173/7206 0.000283140882357 ko00120 Primary bile acid biosynthesis 6/368 20/7206 0.000358175680034 ko05144 Malaria 9/368 45/7206 0.000369115785352 ko05133 Pertussis 13/368 87/7206 0.000425487167347 ko04666 Fc gamma R-mediated phagocytosis 16/368 122/7206 0.000442325136687 ko05323 Rheumatoid arthritis 13/368 89/7206 0.000532979342667 ko04137 Mitophagy - animal 12/368 82/7206 0.000851627196949 ko04670 Leukocyte transendothelial migration 18/368 151/7206 0.000979017633093 ko04622 RIG-I-like receptor signaling pathway 10/368 62/7206 0.00106096909413 ko00590 Arachidonic acid metabolism 9/368 52/7206 0.00111716946393 ko05310 Asthma 5/368 17/7206 0.00125570889973 ko03050 Proteasome 9/368 54/7206 0.00147570492166 ko04310 Wnt signaling pathway 1/368 181/7206 0.00161162120503 ko04664 Fc epsilon RI signaling pathway 11/368 77/7206 0.00169685560465 ko05034 Alcoholism 3/368 238/7206 0.002522539804 ko05142 Chagas disease (American trypanosomiasis) 15/368 130/7206 0.00350150606514 ko00051 Fructose and mannose metabolism 7/368 42/7206 0.00490272942428 ko04940 Type I diabetes mellitus 6/368 32/7206 0.00498289468749 ko04611 Platelet activation 17/368 163/7206 0.00561301064491 ko04390 Hippo signaling pathway 2/368 188/7206 0.00628460764343 ko03040 Spliceosome 1/368 145/7206 0.00699143310592 ko04514 Cell adhesion molecules (CAMs) 14/368 130/7206 0.00736270907137 ko05160 Hepatitis C 16/368 153/7206 0.00769322210767 ko04668 TNF signaling pathway 13/368 120/7206 0.00973009418461 ko04916 Melanogenesis 1/368 142/7206 0.0105151539217 ko04360 Axon guidance 4/368 233/7206 0.0142308686448 ko04210 Apoptosis 17/368 180/7206 0.0145235093369 ko03010 Ribosome 1/368 129/7206 0.0146929332521 ko00980 Metabolism of xenobiotics by cytochrome P450 6/368 40/7206 0.0149874005903 ko05132 Salmonella infection 11/368 98/7206 0.0166299798893 ko04623 Cytosolic DNA-sensing pathway 6/368 41/7206 0.0168249562245 ko05416 Viral myocarditis 7/368 55/7206 0.0209577851191 ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis 2/368 5/7206 0.0234686544021 ko04933 AGE-RAGE signaling pathway in diabetic complications 13/368 135/7206 0.0267214784588 ko04080 Neuroactive ligand-receptor interaction 12/368 423/7206 0.029637692936 ko04911 Insulin secretion 1/368 117/7206 0.0311922767944 ko05204 Chemical carcinogenesis 6/368 48/7206 0.0341355308806 ko05224 Breast cancer 3/368 174/7206 0.0354781645374 ko04723 Retrograde endocannabinoid signaling 3/368 175/7206 0.0355623967949 ko05131 Shigellosis 9/368 82/7206 0.0365627554691 ko00982 Drug metabolism - cytochrome P450 5/368 37/7206 0.0384019950375 ko04972 Pancreatic secretion 1/368 111/7206 0.0458497468446