ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	190/1158	423/7206	7.51916124276e-48
ko04724	Glutamatergic synapse	89/1158	152/7206	1.78181924102e-33
ko05033	Nicotine addiction	47/1158	56/7206	3.73293984701e-29
ko05032	Morphine addiction	65/1158	110/7206	5.34728488505e-25
ko04721	Synaptic vesicle cycle	53/1158	80/7206	5.42024256766e-24
ko04713	Circadian entrainment	72/1158	136/7206	1.39324093496e-23
ko04727	GABAergic synapse	63/1158	110/7206	3.12940878917e-23
ko04728	Dopaminergic synapse	84/1158	185/7206	1.49790622443e-21
ko04725	Cholinergic synapse	74/1158	160/7206	1.11134526405e-19
ko04024	cAMP signaling pathway	103/1158	279/7206	5.23683597521e-18
ko04723	Retrograde endocannabinoid signaling	75/1158	175/7206	1.41560465356e-17
ko04020	Calcium signaling pathway	98/1158	265/7206	3.31094393328e-17
ko04742	Taste transduction	39/1158	61/7206	3.67494925332e-17
ko04726	Serotonergic synapse	59/1158	137/7206	3.44893332081e-14
ko04921	Oxytocin signaling pathway	77/1158	209/7206	1.73541935821e-13
ko04911	Insulin secretion	52/1158	117/7206	2.57066911807e-13
ko04720	Long-term potentiation	45/1158	99/7206	4.08337360228e-12
ko04261	Adrenergic signaling in cardiomyocytes	72/1158	205/7206	1.2214248623e-11
ko04744	Phototransduction	24/1158	36/7206	1.25447071611e-11
ko05031	Amphetamine addiction	41/1158	91/7206	5.26919973234e-11
ko04360	Axon guidance	77/1158	233/7206	7.47840945309e-11
ko03040	Spliceosome	1/1158	145/7206	3.16843828684e-10
ko04970	Salivary secretion	40/1158	95/7206	1.11000982829e-09
ko05203	Viral carcinogenesis	13/1158	277/7206	4.66475746982e-09
ko04966	Collecting duct acid secretion	17/1158	26/7206	2.0913878306e-08
ko05168	Herpes simplex infection	6/1158	182/7206	5.47129805745e-08
ko04740	Olfactory transduction	33/1158	80/7206	5.84977120541e-08
ko04060	Cytokine-cytokine receptor interaction	7/1158	191/7206	6.91970967301e-08
ko04022	cGMP-PKG signaling pathway	65/1158	216/7206	1.48825924267e-07
ko04971	Gastric acid secretion	36/1158	98/7206	5.07433168165e-07
ko05030	Cocaine addiction	29/1158	73/7206	9.55325900323e-07
ko04925	Aldosterone synthesis and secretion	37/1158	105/7206	1.27915398018e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	29/1158	74/7206	1.33343366125e-06
ko05164	Influenza A	7/1158	167/7206	1.93115889282e-06
ko04010	MAPK signaling pathway	84/1158	321/7206	2.47608278902e-06
ko03013	RNA transport	7/1158	166/7206	2.82453111902e-06
ko04621	NOD-like receptor signaling pathway	7/1158	157/7206	8.1405857587e-06
ko04141	Protein processing in endoplasmic reticulum	10/1158	184/7206	1.48125494965e-05
ko05322	Systemic lupus erythematosus	7/1158	151/7206	1.66296347863e-05
ko04924	Renin secretion	30/1158	86/7206	1.8707104138e-05
ko05110	Vibrio cholerae infection	24/1158	63/7206	1.90368844844e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1158	79/7206	2.02340262648e-05
ko04514	Cell adhesion molecules (CAMs)	40/1158	130/7206	2.88501763223e-05
ko04610	Complement and coagulation cascades	1/1158	79/7206	3.40063460595e-05
ko04260	Cardiac muscle contraction	32/1158	98/7206	4.03127308746e-05
ko04540	Gap junction	39/1158	128/7206	4.38119655567e-05
ko04120	Ubiquitin mediated proteolysis	7/1158	138/7206	9.48093225727e-05
ko05169	Epstein-Barr virus infection	14/1158	206/7206	9.96992125077e-05
ko04745	Phototransduction - fly	16/1158	38/7206	0.000117018768122
ko04972	Pancreatic secretion	34/1158	111/7206	0.000117274039263
ko05414	Dilated cardiomyopathy	34/1158	112/7206	0.000131680656597
ko05205	Proteoglycans in cancer	22/1158	271/7206	0.000133046931153
ko04730	Long-term depression	26/1158	78/7206	0.000141614695134
ko04014	Ras signaling pathway	68/1158	279/7206	0.000239232407658
ko04612	Antigen processing and presentation	2/1158	77/7206	0.00025873085621
ko03008	Ribosome biogenesis in eukaryotes	2/1158	79/7206	0.000276229871539
ko05140	Leishmaniasis	2/1158	75/7206	0.000385436429347
ko04064	NF-kappa B signaling pathway	4/1158	96/7206	0.000409350257102
ko05161	Hepatitis B	12/1158	173/7206	0.000480206695944
ko00604	Glycosphingolipid biosynthesis - ganglio series	8/1158	14/7206	0.000524675284921
ko05162	Measles	7/1158	120/7206	0.00099444120166
ko04146	Peroxisome	4/1158	89/7206	0.00120575813013
ko04371	Apelin signaling pathway	45/1158	177/7206	0.00121070166331
ko04110	Cell cycle	10/1158	145/7206	0.00127886586899
ko00480	Glutathione metabolism	1/1158	55/7206	0.00132869615798
ko04070	Phosphatidylinositol signaling system	31/1158	112/7206	0.00164786938351
ko04750	Inflammatory mediator regulation of TRP channels	33/1158	122/7206	0.00172593440875
ko04976	Bile secretion	24/1158	80/7206	0.00180558830282
ko04961	Endocrine and other factor-regulated calcium reabsorption	19/1158	59/7206	0.00195531519207
ko00590	Arachidonic acid metabolism	1/1158	52/7206	0.00198351441098
ko04072	Phospholipase D signaling pathway	48/1158	197/7206	0.00218499908613
ko04214	Apoptosis - fly	3/1158	72/7206	0.00320071621117
ko04915	Estrogen signaling pathway	34/1158	131/7206	0.00362906833779
ko00240	Pyrimidine metabolism	7/1158	110/7206	0.00362949564296
ko04964	Proximal tubule bicarbonate reclamation	11/1158	29/7206	0.00368835228935
ko04626	Plant-pathogen interaction	8/1158	18/7206	0.00418714123367
ko04932	Non-alcoholic fatty liver disease (NAFLD)	16/1158	182/7206	0.00552446515112
ko04630	Jak-STAT signaling pathway	10/1158	132/7206	0.00559823824659
ko05321	Inflammatory bowel disease (IBD)	2/1158	56/7206	0.00576436961149
ko05418	Fluid shear stress and atherosclerosis	15/1158	173/7206	0.00613999810936
ko03022	Basal transcription factors	1/1158	44/7206	0.00671043251049
ko00071	Fatty acid degradation	1/1158	45/7206	0.00682998024166
ko01524	Platinum drug resistance	4/1158	76/7206	0.0069539315906
ko03420	Nucleotide excision repair	1/1158	46/7206	0.00719329106706
ko04668	TNF signaling pathway	9/1158	120/7206	0.00802955674169
ko05410	Hypertrophic cardiomyopathy (HCM)	26/1158	100/7206	0.00908286150795
ko04640	Hematopoietic cell lineage	3/1158	64/7206	0.00940637924808
ko05131	Shigellosis	5/1158	82/7206	0.00972607735773
ko00310	Lysine degradation	4/1158	73/7206	0.00973597045148
ko05145	Toxoplasmosis	10/1158	126/7206	0.00981308466431
ko00330	Arginine and proline metabolism	3/1158	61/7206	0.013328690562
ko04622	RIG-I-like receptor signaling pathway	3/1158	62/7206	0.0136152769813
ko05120	Epithelial cell signaling in Helicobacter pylori infection	24/1158	92/7206	0.0141219637464
ko04916	Melanogenesis	34/1158	142/7206	0.0147359349323
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1158	40/7206	0.0153607904722
ko04657	IL-17 signaling pathway	6/1158	87/7206	0.0177749984249
ko05133	Pertussis	6/1158	87/7206	0.0177749984249
ko05166	HTLV-I infection	33/1158	292/7206	0.0225815560952
ko00982	Drug metabolism - cytochrome P450	1/1158	37/7206	0.0226157857348
ko00630	Glyoxylate and dicarboxylate metabolism	1/1158	38/7206	0.0235176067313
ko04140	Autophagy - animal	16/1158	164/7206	0.0237509851936
ko03018	RNA degradation	6/1158	84/7206	0.023966591139
ko04912	GnRH signaling pathway	29/1158	122/7206	0.0247124890163
ko04930	Type II diabetes mellitus	15/1158	54/7206	0.0249802972592
ko04115	p53 signaling pathway	5/1158	74/7206	0.0253109969377
ko04270	Vascular smooth muscle contraction	35/1158	154/7206	0.026524150165
ko04620	Toll-like receptor signaling pathway	8/1158	100/7206	0.027238035771
ko04923	Regulation of lipolysis in adipocytes	20/1158	77/7206	0.0272579205157
ko05206	MicroRNAs in cancer	18/1158	177/7206	0.0292964825187
ko04217	Necroptosis	18/1158	178/7206	0.0294234290979
ko00640	Propanoate metabolism	1/1158	34/7206	0.0334211722992
ko00500	Starch and sucrose metabolism	1/1158	35/7206	0.0343023370033
ko04658	Th1 and Th2 cell differentiation	8/1158	96/7206	0.0356360159672
ko00561	Glycerolipid metabolism	4/1158	63/7206	0.0368760841788
ko00600	Sphingolipid metabolism	4/1158	63/7206	0.0368760841788
ko00280	Valine, leucine and isoleucine degradation	3/1158	54/7206	0.038342554308
ko05144	Malaria	2/1158	45/7206	0.038470419225
ko00512	Mucin type O-glycan biosynthesis	9/1158	29/7206	0.0393973302801
ko05222	Small cell lung cancer	7/1158	89/7206	0.0403544291609
ko04350	TGF-beta signaling pathway	9/1158	103/7206	0.0419956899469
ko04933	AGE-RAGE signaling pathway in diabetic complications	13/1158	135/7206	0.0434086796125
ko04015	Rap1 signaling pathway	57/1158	278/7206	0.0453450129043
ko03320	PPAR signaling pathway	5/1158	69/7206	0.0469323283648
ko04114	Oocyte meiosis	31/1158	139/7206	0.0474942967319
ko05215	Prostate cancer	10/1158	111/7206	0.0493418828202