ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	184/1104	423/7206	5.13648443077e-47
ko04724	Glutamatergic synapse	83/1104	152/7206	7.99996863403e-30
ko05033	Nicotine addiction	46/1104	56/7206	1.10972602739e-28
ko05032	Morphine addiction	65/1104	110/7206	3.24517498504e-26
ko04713	Circadian entrainment	69/1104	136/7206	1.76527553813e-22
ko04727	GABAergic synapse	60/1104	110/7206	8.61807390819e-22
ko04728	Dopaminergic synapse	80/1104	185/7206	2.77154547088e-20
ko04725	Cholinergic synapse	71/1104	160/7206	7.06176759229e-19
ko04721	Synaptic vesicle cycle	46/1104	80/7206	3.21713239762e-18
ko04723	Retrograde endocannabinoid signaling	74/1104	175/7206	3.65540954055e-18
ko04024	cAMP signaling pathway	98/1104	279/7206	6.08892867131e-17
ko04020	Calcium signaling pathway	93/1104	265/7206	4.41519157473e-16
ko04744	Phototransduction	27/1104	36/7206	1.76873464693e-15
ko04742	Taste transduction	36/1104	61/7206	5.03194963469e-15
ko04921	Oxytocin signaling pathway	75/1104	209/7206	1.07342323523e-13
ko04911	Insulin secretion	50/1104	117/7206	7.15326333756e-13
ko04726	Serotonergic synapse	55/1104	137/7206	1.11502408988e-12
ko04261	Adrenergic signaling in cardiomyocytes	69/1104	205/7206	3.71614989532e-11
ko04720	Long-term potentiation	40/1104	99/7206	1.12746491977e-09
ko03040	Spliceosome	1/1104	145/7206	1.36253791729e-09
ko05031	Amphetamine addiction	37/1104	91/7206	3.87371448549e-09
ko05203	Viral carcinogenesis	12/1104	277/7206	6.61086071078e-09
ko04970	Salivary secretion	37/1104	95/7206	1.55496717264e-08
ko03010	Ribosome	1/1104	129/7206	1.74967819885e-08
ko05322	Systemic lupus erythematosus	4/1104	151/7206	4.93194778394e-07
ko04740	Olfactory transduction	30/1104	80/7206	9.31692389159e-07
ko04022	cGMP-PKG signaling pathway	61/1104	216/7206	1.08503202623e-06
ko04925	Aldosterone synthesis and secretion	36/1104	105/7206	1.46007872974e-06
ko04360	Axon guidance	63/1104	233/7206	2.84462729292e-06
ko04621	NOD-like receptor signaling pathway	6/1104	157/7206	5.30578372986e-06
ko04060	Cytokine-cytokine receptor interaction	9/1104	191/7206	5.40939440112e-06
ko04971	Gastric acid secretion	33/1104	98/7206	5.81112769411e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	27/1104	74/7206	5.95452752424e-06
ko05164	Influenza A	7/1104	167/7206	6.17211769631e-06
ko04070	Phosphatidylinositol signaling system	36/1104	112/7206	7.16700742597e-06
ko03013	RNA transport	7/1104	166/7206	9.06957270989e-06
ko05168	Herpes simplex infection	9/1104	182/7206	1.49241955999e-05
ko04010	MAPK signaling pathway	78/1104	321/7206	1.62640499014e-05
ko05030	Cocaine addiction	26/1104	73/7206	1.95941737826e-05
ko04514	Cell adhesion molecules (CAMs)	39/1104	130/7206	1.97062710628e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1104	79/7206	2.56193067447e-05
ko04072	Phospholipase D signaling pathway	52/1104	197/7206	4.89465863652e-05
ko04745	Phototransduction - fly	16/1104	38/7206	6.48672808749e-05
ko04120	Ubiquitin mediated proteolysis	6/1104	138/7206	6.52631295069e-05
ko04972	Pancreatic secretion	33/1104	111/7206	9.26380254397e-05
ko05169	Epstein-Barr virus infection	13/1104	206/7206	0.000109124525138
ko04141	Protein processing in endoplasmic reticulum	11/1104	184/7206	0.000111022977592
ko05161	Hepatitis B	10/1104	173/7206	0.000154872242521
ko04064	NF-kappa B signaling pathway	3/1104	96/7206	0.000169807882074
ko04730	Long-term depression	25/1104	78/7206	0.000187905924136
ko05414	Dilated cardiomyopathy	32/1104	112/7206	0.000290793604786
ko04260	Cardiac muscle contraction	29/1104	98/7206	0.000314100208978
ko04710	Circadian rhythm	16/1104	43/7206	0.000362930035436
ko04110	Cell cycle	8/1104	145/7206	0.000403456861253
ko04610	Complement and coagulation cascades	2/1104	79/7206	0.000410869078094
ko03008	Ribosome biogenesis in eukaryotes	2/1104	79/7206	0.000410869078094
ko04540	Gap junction	35/1104	128/7206	0.000435867317606
ko05140	Leishmaniasis	2/1104	75/7206	0.000599150772444
ko04612	Antigen processing and presentation	2/1104	77/7206	0.000623660000814
ko04966	Collecting duct acid secretion	11/1104	26/7206	0.000868923868743
ko04014	Ras signaling pathway	63/1104	279/7206	0.00119570859111
ko04924	Renin secretion	25/1104	86/7206	0.00124727117959
ko05205	Proteoglycans in cancer	24/1104	271/7206	0.0018796482463
ko05162	Measles	7/1104	120/7206	0.00197969904733
ko04964	Proximal tubule bicarbonate reclamation	11/1104	29/7206	0.0025047463772
ko05166	HTLV-I infection	27/1104	292/7206	0.00270354363456
ko04626	Plant-pathogen interaction	8/1104	18/7206	0.00307857317391
ko00590	Arachidonic acid metabolism	1/1104	52/7206	0.00311291960289
ko04750	Inflammatory mediator regulation of TRP channels	31/1104	122/7206	0.0032925729289
ko00562	Inositol phosphate metabolism	24/1104	89/7206	0.00435949717209
ko05410	Hypertrophic cardiomyopathy (HCM)	26/1104	100/7206	0.00485711021877
ko04371	Apelin signaling pathway	41/1104	177/7206	0.00568467154197
ko04923	Regulation of lipolysis in adipocytes	21/1104	77/7206	0.00623100614446
ko04915	Estrogen signaling pathway	32/1104	131/7206	0.00656055546398
ko03420	Nucleotide excision repair	1/1104	46/7206	0.00694321753596
ko04146	Peroxisome	5/1104	89/7206	0.00725448692336
ko04711	Circadian rhythm - fly	6/1104	13/7206	0.00831053915358
ko05321	Inflammatory bowel disease (IBD)	2/1104	56/7206	0.00868437748877
ko04657	IL-17 signaling pathway	5/1104	87/7206	0.0101198755904
ko03022	Basal transcription factors	1/1104	44/7206	0.0104216188982
ko04510	Focal adhesion	23/1104	240/7206	0.0105188472799
ko00071	Fatty acid degradation	1/1104	45/7206	0.0107716714171
ko04976	Bile secretion	21/1104	80/7206	0.0113962086558
ko00280	Valine, leucine and isoleucine degradation	2/1104	54/7206	0.0126297489743
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1104	14/7206	0.0126861093171
ko00480	Glutathione metabolism	2/1104	55/7206	0.0129257749511
ko04640	Hematopoietic cell lineage	3/1104	64/7206	0.0137249196125
ko04115	p53 signaling pathway	4/1104	74/7206	0.0140626918411
ko04217	Necroptosis	16/1104	178/7206	0.0151856629939
ko00240	Pyrimidine metabolism	8/1104	110/7206	0.0157816072743
ko05145	Toxoplasmosis	10/1104	126/7206	0.0174349727215
ko00330	Arginine and proline metabolism	3/1104	61/7206	0.0193920856411
ko04330	Notch signaling pathway	3/1104	62/7206	0.0196991329473
ko04622	RIG-I-like receptor signaling pathway	3/1104	62/7206	0.0196991329473
ko04214	Apoptosis - fly	4/1104	72/7206	0.0198512846287
ko05110	Vibrio cholerae infection	17/1104	63/7206	0.0203711101253
ko04930	Type II diabetes mellitus	15/1104	54/7206	0.0204247565963
ko03410	Base excision repair	1/1104	38/7206	0.0229791559775
ko05200	Pathways in cancer	58/1104	492/7206	0.0232060401716
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1104	40/7206	0.0243119599087
ko05133	Pertussis	6/1104	87/7206	0.0244151937994
ko05222	Small cell lung cancer	6/1104	89/7206	0.0249394996153
ko04922	Glucagon signaling pathway	29/1104	128/7206	0.0253291368391
ko04630	Jak-STAT signaling pathway	11/1104	132/7206	0.027136237728
ko04210	Apoptosis	17/1104	180/7206	0.0271834410518
ko03320	PPAR signaling pathway	4/1104	69/7206	0.0273792942808
ko00380	Tryptophan metabolism	2/1104	50/7206	0.0274410611927
ko05231	Choline metabolism in cancer	30/1104	134/7206	0.0285460578448
ko03018	RNA degradation	6/1104	84/7206	0.0328455795562
ko05215	Prostate cancer	9/1104	111/7206	0.0329298818877
ko00982	Drug metabolism - cytochrome P450	1/1104	37/7206	0.0355146044748
ko01524	Platinum drug resistance	5/1104	76/7206	0.0357371983478
ko00230	Purine metabolism	40/1104	194/7206	0.0429996519434
ko04961	Endocrine and other factor-regulated calcium reabsorption	15/1104	59/7206	0.0433629137028
ko05131	Shigellosis	6/1104	82/7206	0.0440479512403
ko04722	Neurotrophin signaling pathway	34/1104	160/7206	0.0448125506326
ko00310	Lysine degradation	5/1104	73/7206	0.0482302592588