ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	170/993	423/7206	2.56020773662e-44
ko04724	Glutamatergic synapse	87/993	152/7206	5.27072208842e-37
ko05033	Nicotine addiction	46/993	56/7206	9.07366406897e-31
ko05032	Morphine addiction	63/993	110/7206	5.04748011013e-27
ko04713	Circadian entrainment	71/993	136/7206	6.01385467995e-27
ko04727	GABAergic synapse	62/993	110/7206	4.40868599485e-26
ko04728	Dopaminergic synapse	82/993	185/7206	9.74215197266e-25
ko04723	Retrograde endocannabinoid signaling	75/993	175/7206	1.31260100991e-21
ko04725	Cholinergic synapse	70/993	160/7206	7.52203916497e-21
ko04721	Synaptic vesicle cycle	46/993	80/7206	4.0103394205e-20
ko04024	cAMP signaling pathway	92/993	279/7206	7.14564944103e-17
ko04911	Insulin secretion	51/993	117/7206	2.04552860435e-15
ko04921	Oxytocin signaling pathway	72/993	209/7206	1.21556122299e-14
ko04726	Serotonergic synapse	54/993	137/7206	5.21790545874e-14
ko05031	Amphetamine addiction	40/993	91/7206	1.65689955604e-12
ko04261	Adrenergic signaling in cardiomyocytes	67/993	205/7206	1.82709463111e-12
ko04720	Long-term potentiation	42/993	99/7206	1.95493682986e-12
ko04020	Calcium signaling pathway	80/993	265/7206	2.0266544337e-12
ko04744	Phototransduction	23/993	36/7206	4.88239123932e-12
ko04742	Taste transduction	31/993	61/7206	4.94632044331e-12
ko04970	Salivary secretion	36/993	95/7206	3.22658040469e-09
ko03040	Spliceosome	1/993	145/7206	1.44213542032e-08
ko04925	Aldosterone synthesis and secretion	37/993	105/7206	1.94813492398e-08
ko05203	Viral carcinogenesis	11/993	277/7206	6.02486544327e-08
ko05168	Herpes simplex infection	4/993	182/7206	8.59268078123e-08
ko04060	Cytokine-cytokine receptor interaction	5/993	191/7206	1.78473561383e-07
ko04740	Olfactory transduction	29/993	80/7206	3.35633596615e-07
ko05030	Cocaine addiction	27/993	73/7206	5.35196654158e-07
ko04022	cGMP-PKG signaling pathway	57/993	216/7206	5.90267719527e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	27/993	74/7206	7.33871847946e-07
ko04360	Axon guidance	59/993	233/7206	1.63058002668e-06
ko04971	Gastric acid secretion	32/993	98/7206	1.7034791281e-06
ko04010	MAPK signaling pathway	75/993	321/7206	1.9114640897e-06
ko04972	Pancreatic secretion	34/993	111/7206	4.24017791249e-06
ko04730	Long-term depression	26/993	78/7206	8.15516590844e-06
ko04621	NOD-like receptor signaling pathway	5/993	157/7206	1.07054262302e-05
ko04966	Collecting duct acid secretion	13/993	26/7206	1.08997474564e-05
ko05322	Systemic lupus erythematosus	5/993	151/7206	2.21655909648e-05
ko04514	Cell adhesion molecules (CAMs)	36/993	130/7206	2.62778415334e-05
ko04260	Cardiac muscle contraction	29/993	98/7206	4.07165494486e-05
ko04072	Phospholipase D signaling pathway	48/993	197/7206	5.46084736161e-05
ko04745	Phototransduction - fly	15/993	38/7206	7.66203445267e-05
ko03013	RNA transport	7/993	166/7206	8.38497629122e-05
ko04070	Phosphatidylinositol signaling system	31/993	112/7206	8.46908585529e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	24/993	79/7206	0.000106422555992
ko04120	Ubiquitin mediated proteolysis	5/993	138/7206	0.000139604441511
ko04610	Complement and coagulation cascades	1/993	79/7206	0.000204103500375
ko05164	Influenza A	8/993	167/7206	0.000233531457399
ko04540	Gap junction	33/993	128/7206	0.000242774116813
ko05110	Vibrio cholerae infection	20/993	63/7206	0.00027482568726
ko04141	Protein processing in endoplasmic reticulum	10/993	184/7206	0.000320288531864
ko04915	Estrogen signaling pathway	33/993	131/7206	0.000450183899479
ko04110	Cell cycle	7/993	145/7206	0.000597749273352
ko04924	Renin secretion	24/993	86/7206	0.000709880847725
ko05414	Dilated cardiomyopathy	29/993	112/7206	0.00073245096376
ko05169	Epstein-Barr virus infection	13/993	206/7206	0.000935761471098
ko04014	Ras signaling pathway	58/993	279/7206	0.000989658608646
ko04750	Inflammatory mediator regulation of TRP channels	30/993	122/7206	0.00126360321333
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/993	14/7206	0.00130904271103
ko03008	Ribosome biogenesis in eukaryotes	2/993	79/7206	0.0014543205605
ko04626	Plant-pathogen interaction	8/993	18/7206	0.00153419000294
ko04961	Endocrine and other factor-regulated calcium reabsorption	17/993	59/7206	0.00205729914305
ko05205	Proteoglycans in cancer	21/993	271/7206	0.00219213004968
ko04612	Antigen processing and presentation	2/993	77/7206	0.00221456844381
ko04976	Bile secretion	21/993	80/7206	0.00280110382714
ko05162	Measles	6/993	120/7206	0.00298134135998
ko04214	Apoptosis - fly	2/993	72/7206	0.00303345995917
ko04964	Proximal tubule bicarbonate reclamation	10/993	29/7206	0.00394177276333
ko04064	NF-kappa B signaling pathway	4/993	96/7206	0.0040286226527
ko00480	Glutathione metabolism	1/993	55/7206	0.00504195406989
ko05410	Hypertrophic cardiomyopathy (HCM)	24/993	100/7206	0.0051030040402
ko04912	GnRH signaling pathway	28/993	122/7206	0.00511425066079
ko04973	Carbohydrate digestion and absorption	13/993	42/7206	0.00512240256954
ko04371	Apelin signaling pathway	38/993	177/7206	0.00540327776274
ko05161	Hepatitis B	12/993	173/7206	0.00696774657083
ko04630	Jak-STAT signaling pathway	8/993	132/7206	0.00703198310944
ko00590	Arachidonic acid metabolism	1/993	52/7206	0.00749217154257
ko04146	Peroxisome	4/993	89/7206	0.00774047433369
ko04330	Notch signaling pathway	2/993	62/7206	0.00927077591716
ko04640	Hematopoietic cell lineage	2/993	64/7206	0.00946293129895
ko00310	Lysine degradation	3/993	73/7206	0.0102766851493
ko05140	Leishmaniasis	3/993	75/7206	0.0104226643254
ko05219	Bladder cancer	1/993	48/7206	0.0110300280822
ko04923	Regulation of lipolysis in adipocytes	19/993	77/7206	0.0112403647832
ko05166	HTLV-I infection	26/993	292/7206	0.0118182830323
ko00562	Inositol phosphate metabolism	21/993	89/7206	0.0121583622971
ko04922	Glucagon signaling pathway	28/993	128/7206	0.0130949416545
ko04140	Autophagy - animal	12/993	164/7206	0.0154054731691
ko04930	Type II diabetes mellitus	14/993	54/7206	0.0157141744156
ko00071	Fatty acid degradation	1/993	45/7206	0.0163459845615
ko03420	Nucleotide excision repair	1/993	46/7206	0.0164695837153
ko04918	Thyroid hormone synthesis	20/993	86/7206	0.0169053126674
ko05215	Prostate cancer	7/993	111/7206	0.0178804718778
ko05321	Inflammatory bowel disease (IBD)	2/993	56/7206	0.0192492720358
ko03320	PPAR signaling pathway	3/993	69/7206	0.0208053104532
ko04062	Chemokine signaling pathway	39/993	201/7206	0.022349601392
ko04657	IL-17 signaling pathway	5/993	87/7206	0.0273213606779
ko00280	Valine, leucine and isoleucine degradation	2/993	54/7206	0.0277034684248
ko05010	Alzheimer's disease	39/993	202/7206	0.0289415781811
ko05120	Epithelial cell signaling in Helicobacter pylori infection	20/993	92/7206	0.0323795398477
ko04114	Oocyte meiosis	28/993	139/7206	0.0340819230648
ko05034	Alcoholism	44/993	238/7206	0.0354341928125
ko00980	Metabolism of xenobiotics by cytochrome P450	1/993	40/7206	0.0359474562388
ko00140	Steroid hormone biosynthesis	1/993	41/7206	0.036957957195
ko03018	RNA degradation	5/993	84/7206	0.0370614406377
ko04115	p53 signaling pathway	4/993	74/7206	0.0397319922473
ko00330	Arginine and proline metabolism	3/993	61/7206	0.0400202042827
ko04622	RIG-I-like receptor signaling pathway	3/993	62/7206	0.040207094594
ko04350	TGF-beta signaling pathway	7/993	103/7206	0.0423233704397
ko00533	Glycosaminoglycan biosynthesis - keratan sulfate	5/993	15/7206	0.0449153225424
ko05214	Glioma	17/993	79/7206	0.0494887164678
ko00240	Pyrimidine metabolism	8/993	110/7206	0.0498003667874
ko04071	Sphingolipid signaling pathway	31/993	162/7206	0.0499710595853