ko pathway ratio_in_study ratio_in_pop p_value ko05217 Basal cell carcinoma 29/567 68/7206 3.56581815807e-15 ko03040 Spliceosome 43/567 145/7206 5.1069643462e-15 ko04550 Signaling pathways regulating pluripotency of stem cells 43/567 165/7206 7.48818932258e-13 ko04080 Neuroactive ligand-receptor interaction 3/567 423/7206 5.15418003149e-12 ko04390 Hippo signaling pathway 42/567 188/7206 2.99498396518e-10 ko03030 DNA replication 16/567 38/7206 7.61713373427e-09 ko04340 Hedgehog signaling pathway 19/567 58/7206 4.02494826729e-08 ko04310 Wnt signaling pathway 36/567 181/7206 1.41063844097e-07 ko04110 Cell cycle 31/567 145/7206 1.97149111229e-07 ko05224 Breast cancer 34/567 174/7206 4.89988158163e-07 ko04330 Notch signaling pathway 18/567 62/7206 7.11321474396e-07 ko04360 Axon guidance 40/567 233/7206 2.52372986176e-06 ko03410 Base excision repair 13/567 38/7206 3.32644122124e-06 ko04950 Maturity onset diabetes of the young 11/567 29/7206 6.06205249454e-06 ko04932 Non-alcoholic fatty liver disease (NAFLD) 1/567 182/7206 8.74507575981e-06 ko04111 Cell cycle - yeast 20/567 90/7206 1.61434942768e-05 ko04020 Calcium signaling pathway 5/567 265/7206 3.52448859071e-05 ko05205 Proteoglycans in cancer 41/567 271/7206 4.22977317426e-05 ko05010 Alzheimer's disease 3/567 202/7206 9.46839124015e-05 ko05200 Pathways in cancer 61/567 492/7206 0.000254526842548 ko04726 Serotonergic synapse 1/567 137/7206 0.000302132467326 ko04144 Endocytosis 11/567 342/7206 0.000423903337632 ko04391 Hippo signaling pathway - fly 17/567 90/7206 0.00055028936696 ko04350 TGF-beta signaling pathway 19/567 103/7206 0.000565887938294 ko04723 Retrograde endocannabinoid signaling 3/567 175/7206 0.000571242074789 ko05202 Transcriptional misregulation in cancer 28/567 188/7206 0.00086180798248 ko04921 Oxytocin signaling pathway 5/567 209/7206 0.00103238305651 ko05166 HTLV-I infection 39/567 292/7206 0.0011426330309 ko03015 mRNA surveillance pathway 17/567 93/7206 0.00127927290778 ko04725 Cholinergic synapse 3/567 160/7206 0.00163612571823 ko04062 Chemokine signaling pathway 5/567 201/7206 0.00199255410775 ko04727 GABAergic synapse 1/567 110/7206 0.0020436577882 ko03420 Nucleotide excision repair 10/567 46/7206 0.00256262518748 ko03050 Proteasome 11/567 54/7206 0.0027504999443 ko04072 Phospholipase D signaling pathway 5/567 197/7206 0.00278910968499 ko04630 Jak-STAT signaling pathway 2/567 132/7206 0.0028031822726 ko04113 Meiosis - yeast 13/567 70/7206 0.00281238552005 ko05231 Choline metabolism in cancer 2/567 134/7206 0.00291841010115 ko05169 Epstein-Barr virus infection 28/567 206/7206 0.00367100049822 ko05206 MicroRNAs in cancer 25/567 177/7206 0.00413355561619 ko05222 Small cell lung cancer 15/567 89/7206 0.00434559714951 ko04066 HIF-1 signaling pathway 2/567 123/7206 0.00587903166843 ko05211 Renal cell carcinoma 1/567 96/7206 0.00647960710308 ko04260 Cardiac muscle contraction 1/567 98/7206 0.00674835528941 ko04612 Antigen processing and presentation 13/567 77/7206 0.00831706971 ko04920 Adipocytokine signaling pathway 1/567 89/7206 0.00934230404021 ko04916 Melanogenesis 20/567 142/7206 0.0105814115925 ko05414 Dilated cardiomyopathy 2/567 112/7206 0.0117826000075 ko04013 MAPK signaling pathway - fly 17/567 115/7206 0.0126788957384 ko04662 B cell receptor signaling pathway 1/567 88/7206 0.0144028126494 ko03460 Fanconi anemia pathway 9/567 51/7206 0.0167020784956 ko00240 Pyrimidine metabolism 16/567 110/7206 0.0180557696317 ko04610 Complement and coagulation cascades 1/567 79/7206 0.0197978336135 ko04976 Bile secretion 1/567 80/7206 0.0198976208579 ko04138 Autophagy - yeast 1/567 81/7206 0.0201289469977 ko04217 Necroptosis 6/567 178/7206 0.0228733692162 ko04971 Gastric acid secretion 2/567 98/7206 0.0230522632319 ko04720 Long-term potentiation 2/567 99/7206 0.0230649547502 ko03020 RNA polymerase 6/567 29/7206 0.0230653241278 ko05410 Hypertrophic cardiomyopathy (HCM) 2/567 100/7206 0.0231957043338 ko04139 Mitophagy - yeast 7/567 37/7206 0.0232795742116 ko04621 NOD-like receptor signaling pathway 5/567 157/7206 0.0237287429527 ko03430 Mismatch repair 5/567 22/7206 0.0253903730292 ko04341 Hedgehog signaling pathway - fly 7/567 38/7206 0.0266687617432 ko04910 Insulin signaling pathway 6/567 172/7206 0.0302351091705 ko04730 Long-term depression 1/567 78/7206 0.0305291481971 ko04915 Estrogen signaling pathway 4/567 131/7206 0.0331341064926 ko04070 Phosphatidylinositol signaling system 3/567 112/7206 0.0335941156214 ko04011 MAPK signaling pathway - yeast 9/567 53/7206 0.0339465170581 ko04713 Circadian entrainment 4/567 136/7206 0.0343295387481 ko04022 cGMP-PKG signaling pathway 9/567 216/7206 0.0393577612729 ko03320 PPAR signaling pathway 1/567 69/7206 0.0416640932743 ko05418 Fluid shear stress and atherosclerosis 21/567 173/7206 0.0439775599412 ko01200 Carbon metabolism 4/567 128/7206 0.0451263005234 ko04922 Glucagon signaling pathway 4/567 128/7206 0.0451263005234 ko04972 Pancreatic secretion 3/567 111/7206 0.0476341255943 ko04371 Apelin signaling pathway 7/567 177/7206 0.0476860070112