ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	143/815	423/7206	2.13095196586e-37
ko04724	Glutamatergic synapse	73/815	152/7206	2.51822085353e-30
ko05033	Nicotine addiction	39/815	56/7206	7.86482800693e-25
ko04721	Synaptic vesicle cycle	45/815	80/7206	9.98017760864e-23
ko05032	Morphine addiction	53/815	110/7206	2.43821629004e-22
ko04728	Dopaminergic synapse	69/815	185/7206	7.59031416457e-21
ko04713	Circadian entrainment	57/815	136/7206	3.06368320142e-20
ko04727	GABAergic synapse	50/815	110/7206	9.6727917362e-20
ko04723	Retrograde endocannabinoid signaling	63/815	175/7206	3.32334268669e-18
ko04725	Cholinergic synapse	58/815	160/7206	5.27290376499e-17
ko04024	cAMP signaling pathway	79/815	279/7206	1.52529017651e-15
ko04921	Oxytocin signaling pathway	64/815	209/7206	1.56910039229e-14
ko04911	Insulin secretion	42/815	117/7206	1.78139823667e-12
ko04261	Adrenergic signaling in cardiomyocytes	58/815	205/7206	1.13131027502e-11
ko04020	Calcium signaling pathway	69/815	265/7206	1.38041599156e-11
ko04726	Serotonergic synapse	44/815	137/7206	3.99592353951e-11
ko04742	Taste transduction	27/815	61/7206	6.65129236394e-11
ko05031	Amphetamine addiction	34/815	91/7206	6.7877585527e-11
ko04720	Long-term potentiation	35/815	99/7206	2.12891798947e-10
ko04925	Aldosterone synthesis and secretion	32/815	105/7206	7.75103281124e-08
ko04970	Salivary secretion	30/815	95/7206	8.16822576672e-08
ko04966	Collecting duct acid secretion	14/815	26/7206	1.31659287163e-07
ko05030	Cocaine addiction	24/815	73/7206	7.11178720949e-07
ko03040	Spliceosome	1/815	145/7206	8.49589431878e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	24/815	74/7206	9.41838287609e-07
ko04730	Long-term depression	24/815	78/7206	2.72411938738e-06
ko04010	MAPK signaling pathway	64/815	321/7206	4.99316675143e-06
ko04971	Gastric acid secretion	27/815	98/7206	6.92337114312e-06
ko05168	Herpes simplex infection	4/815	182/7206	7.55184532192e-06
ko05110	Vibrio cholerae infection	20/815	63/7206	1.09072064292e-05
ko04060	Cytokine-cytokine receptor interaction	5/815	191/7206	1.3437803045e-05
ko04514	Cell adhesion molecules (CAMs)	32/815	130/7206	1.60537520373e-05
ko04022	cGMP-PKG signaling pathway	45/815	216/7206	4.16751998296e-05
ko05203	Viral carcinogenesis	12/815	277/7206	4.271510796e-05
ko04744	Phototransduction	13/815	36/7206	8.64321728097e-05
ko05322	Systemic lupus erythematosus	4/815	151/7206	0.000135983059336
ko04745	Phototransduction - fly	13/815	38/7206	0.000163274360054
ko04924	Renin secretion	22/815	86/7206	0.000192870994658
ko04540	Gap junction	29/815	128/7206	0.000196316121037
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	21/815	79/7206	0.000198300393235
ko04972	Pancreatic secretion	26/815	111/7206	0.000227241974788
ko04915	Estrogen signaling pathway	29/815	131/7206	0.000379586749227
ko05414	Dilated cardiomyopathy	26/815	112/7206	0.000394565570119
ko04626	Plant-pathogen interaction	8/815	18/7206	0.000400348138842
ko05164	Influenza A	6/815	167/7206	0.000479674848084
ko04740	Olfactory transduction	20/815	80/7206	0.000504597651901
ko04260	Cardiac muscle contraction	23/815	98/7206	0.000552349834305
ko04120	Ubiquitin mediated proteolysis	4/815	138/7206	0.000567125200946
ko04961	Endocrine and other factor-regulated calcium reabsorption	16/815	59/7206	0.000619059112029
ko05162	Measles	3/815	120/7206	0.000681136344298
ko03013	RNA transport	6/815	166/7206	0.000687289401314
ko04014	Ras signaling pathway	50/815	279/7206	0.00095158100632
ko04750	Inflammatory mediator regulation of TRP channels	26/815	122/7206	0.0012663212104
ko04621	NOD-like receptor signaling pathway	6/815	157/7206	0.00128331884327
ko05120	Epithelial cell signaling in Helicobacter pylori infection	21/815	92/7206	0.0013541609966
ko04612	Antigen processing and presentation	1/815	77/7206	0.00172953982521
ko03008	Ribosome biogenesis in eukaryotes	1/815	79/7206	0.00182028855799
ko04072	Phospholipase D signaling pathway	37/815	197/7206	0.00186281446133
ko04922	Glucagon signaling pathway	26/815	128/7206	0.00272863687917
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/815	14/7206	0.00276837224877
ko04141	Protein processing in endoplasmic reticulum	9/815	184/7206	0.00308163070624
ko04110	Cell cycle	6/815	145/7206	0.00332174526719
ko04146	Peroxisome	2/815	89/7206	0.0035134016917
ko04070	Phosphatidylinositol signaling system	23/815	112/7206	0.00387107702533
ko05410	Hypertrophic cardiomyopathy (HCM)	21/815	100/7206	0.00400038398703
ko04360	Axon guidance	41/815	233/7206	0.00422651353308
ko05169	Epstein-Barr virus infection	11/815	206/7206	0.00490359740073
ko05205	Proteoglycans in cancer	17/815	271/7206	0.00597459606461
ko05323	Rheumatoid arthritis	19/815	89/7206	0.00603498532649
ko05161	Hepatitis B	9/815	173/7206	0.0072598080745
ko04371	Apelin signaling pathway	32/815	177/7206	0.0076371065157
ko04064	NF-kappa B signaling pathway	3/815	96/7206	0.00833155691385
ko04114	Oocyte meiosis	26/815	139/7206	0.00945855603979
ko00680	Methane metabolism	9/815	34/7206	0.0111544835719
ko04630	Jak-STAT signaling pathway	6/815	132/7206	0.0116342843023
ko00330	Arginine and proline metabolism	1/815	61/7206	0.0126681229305
ko05166	HTLV-I infection	20/815	292/7206	0.0137585097559
ko04214	Apoptosis - fly	2/815	72/7206	0.0146008221326
ko00310	Lysine degradation	2/815	73/7206	0.0146413034643
ko05140	Leishmaniasis	2/815	75/7206	0.015244132122
ko04930	Type II diabetes mellitus	12/815	54/7206	0.0170808271783
ko05010	Alzheimer's disease	34/815	202/7206	0.0173061343317
ko00520	Amino sugar and nucleotide sugar metabolism	1/815	55/7206	0.0177910892843
ko00480	Glutathione metabolism	1/815	55/7206	0.0177910892843
ko00240	Pyrimidine metabolism	5/815	110/7206	0.0217475387401
ko05215	Prostate cancer	5/815	111/7206	0.0220503199994
ko00190	Oxidative phosphorylation	23/815	127/7206	0.0224262046067
ko00590	Arachidonic acid metabolism	1/815	52/7206	0.0261868691776
ko00280	Valine, leucine and isoleucine degradation	1/815	54/7206	0.0274505939252
ko04912	GnRH signaling pathway	22/815	122/7206	0.0289396054241
ko04962	Vasopressin-regulated water reabsorption	12/815	58/7206	0.0344593666132
ko04510	Focal adhesion	17/815	240/7206	0.0374576037321
ko05219	Bladder cancer	1/815	48/7206	0.0382208829456
ko04270	Vascular smooth muscle contraction	26/815	154/7206	0.0382354537492
ko04964	Proximal tubule bicarbonate reclamation	7/815	29/7206	0.0389144317835
ko04330	Notch signaling pathway	2/815	62/7206	0.0422663459068
ko04115	p53 signaling pathway	3/815	74/7206	0.0427042651636
ko00561	Glycerolipid metabolism	2/815	63/7206	0.0428527835606
ko01524	Platinum drug resistance	3/815	76/7206	0.0431009865699
ko04145	Phagosome	27/815	162/7206	0.0433149755866
ko04640	Hematopoietic cell lineage	2/815	64/7206	0.0438619229033
ko05034	Alcoholism	37/815	238/7206	0.0470490497361