ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	159/931	423/7206	9.48284812797e-41
ko04724	Glutamatergic synapse	81/931	152/7206	1.55734342232e-33
ko05032	Morphine addiction	64/931	110/7206	1.22232440391e-29
ko05033	Nicotine addiction	43/931	56/7206	9.07276567166e-28
ko04727	GABAergic synapse	62/931	110/7206	1.13330673413e-27
ko04723	Retrograde endocannabinoid signaling	73/931	175/7206	6.46405631021e-22
ko04728	Dopaminergic synapse	75/931	185/7206	1.37575854081e-21
ko04713	Circadian entrainment	61/931	136/7206	2.06629704715e-20
ko04725	Cholinergic synapse	66/931	160/7206	1.36177961112e-19
ko04721	Synaptic vesicle cycle	44/931	80/7206	2.20367336951e-19
ko04024	cAMP signaling pathway	89/931	279/7206	3.47712490223e-17
ko04911	Insulin secretion	49/931	117/7206	3.74337452756e-15
ko04726	Serotonergic synapse	52/931	137/7206	6.60242990439e-14
ko04744	Phototransduction	24/931	36/7206	9.57794857267e-14
ko04742	Taste transduction	32/931	61/7206	1.1566857182e-13
ko04921	Oxytocin signaling pathway	65/931	209/7206	2.63619707568e-12
ko04020	Calcium signaling pathway	76/931	265/7206	3.9163968342e-12
ko04261	Adrenergic signaling in cardiomyocytes	63/931	205/7206	1.00329565233e-11
ko05031	Amphetamine addiction	35/931	91/7206	5.79166039502e-10
ko04720	Long-term potentiation	36/931	99/7206	2.00949976483e-09
ko04970	Salivary secretion	34/931	95/7206	9.08402460618e-09
ko05030	Cocaine addiction	28/931	73/7206	3.31693680046e-08
ko03040	Spliceosome	1/931	145/7206	5.75066871943e-08
ko04925	Aldosterone synthesis and secretion	34/931	105/7206	1.55603916834e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	26/931	74/7206	7.72433121842e-07
ko04010	MAPK signaling pathway	71/931	321/7206	3.32451748307e-06
ko04072	Phospholipase D signaling pathway	49/931	197/7206	4.04042982275e-06
ko04971	Gastric acid secretion	30/931	98/7206	4.30062196014e-06
ko04060	Cytokine-cytokine receptor interaction	6/931	191/7206	4.92153533531e-06
ko05203	Viral carcinogenesis	13/931	277/7206	5.84844740021e-06
ko04972	Pancreatic secretion	32/931	111/7206	9.52399985673e-06
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	25/931	79/7206	1.07846063225e-05
ko05164	Influenza A	5/931	167/7206	1.16279149961e-05
ko04514	Cell adhesion molecules (CAMs)	35/931	130/7206	1.50395920692e-05
ko05322	Systemic lupus erythematosus	4/931	151/7206	2.04690549243e-05
ko05414	Dilated cardiomyopathy	31/931	112/7206	2.40735727102e-05
ko04022	cGMP-PKG signaling pathway	50/931	216/7206	2.93945794533e-05
ko05168	Herpes simplex infection	7/931	182/7206	4.42414650301e-05
ko04260	Cardiac muscle contraction	28/931	98/7206	4.63916382367e-05
ko03013	RNA transport	6/931	166/7206	5.62185653147e-05
ko04740	Olfactory transduction	24/931	80/7206	5.79470115016e-05
ko04141	Protein processing in endoplasmic reticulum	8/931	184/7206	0.000128335774388
ko04621	NOD-like receptor signaling pathway	6/931	157/7206	0.000158131606862
ko04070	Phosphatidylinositol signaling system	29/931	112/7206	0.0001698273092
ko04360	Axon guidance	50/931	233/7206	0.000213594314953
ko04730	Long-term depression	22/931	78/7206	0.00026181437545
ko04120	Ubiquitin mediated proteolysis	5/931	138/7206	0.00028415311793
ko04915	Estrogen signaling pathway	32/931	131/7206	0.0003020316006
ko05110	Vibrio cholerae infection	19/931	63/7206	0.000404488333445
ko04540	Gap junction	31/931	128/7206	0.000437407211045
ko03008	Ribosome biogenesis in eukaryotes	1/931	79/7206	0.000512383731805
ko04110	Cell cycle	6/931	145/7206	0.000618055115951
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/931	14/7206	0.000882842593726
ko04966	Collecting duct acid secretion	10/931	26/7206	0.000927408156811
ko04976	Bile secretion	21/931	80/7206	0.00113821362598
ko05205	Proteoglycans in cancer	18/931	271/7206	0.00114104822698
ko05161	Hepatitis B	9/931	173/7206	0.00118026592782
ko04961	Endocrine and other factor-regulated calcium reabsorption	17/931	59/7206	0.00119835924789
ko04064	NF-kappa B signaling pathway	3/931	96/7206	0.00184515009824
ko04745	Phototransduction - fly	12/931	38/7206	0.00218169758576
ko05162	Measles	5/931	120/7206	0.00221670200145
ko04640	Hematopoietic cell lineage	1/931	64/7206	0.00235431054768
ko05169	Epstein-Barr virus infection	13/931	206/7206	0.00295738827921
ko04924	Renin secretion	21/931	86/7206	0.0031363883084
ko04612	Antigen processing and presentation	2/931	77/7206	0.00317706484817
ko04014	Ras signaling pathway	53/931	279/7206	0.00341170930351
ko04750	Inflammatory mediator regulation of TRP channels	27/931	122/7206	0.00399562971062
ko05145	Toxoplasmosis	6/931	126/7206	0.0043887879943
ko04510	Focal adhesion	17/931	240/7206	0.00440280468144
ko05140	Leishmaniasis	2/931	75/7206	0.00474499127399
ko04923	Regulation of lipolysis in adipocytes	19/931	77/7206	0.00525077213895
ko00480	Glutathione metabolism	1/931	55/7206	0.00772258013266
ko03018	RNA degradation	3/931	84/7206	0.00778625203676
ko04918	Thyroid hormone synthesis	20/931	86/7206	0.00852483325447
ko04964	Proximal tubule bicarbonate reclamation	9/931	29/7206	0.00866667999047
ko04210	Apoptosis	12/931	180/7206	0.00927825928945
ko05410	Hypertrophic cardiomyopathy (HCM)	22/931	100/7206	0.0101315653285
ko04350	TGF-beta signaling pathway	5/931	103/7206	0.0110994680484
ko04140	Autophagy - animal	11/931	164/7206	0.0131947637369
ko00240	Pyrimidine metabolism	6/931	110/7206	0.0145192200133
ko05215	Prostate cancer	6/931	111/7206	0.014585731619
ko04146	Peroxisome	4/931	89/7206	0.0156964541708
ko05222	Small cell lung cancer	4/931	89/7206	0.0156964541708
ko04371	Apelin signaling pathway	34/931	177/7206	0.0165649349233
ko00260	Glycine, serine and threonine metabolism	1/931	48/7206	0.0168469386242
ko05219	Bladder cancer	1/931	48/7206	0.0168469386242
ko04630	Jak-STAT signaling pathway	8/931	132/7206	0.0174409911898
ko00330	Arginine and proline metabolism	2/931	61/7206	0.0199177078128
ko04930	Type II diabetes mellitus	13/931	54/7206	0.0227330818653
ko04218	Cellular senescence	13/931	177/7206	0.0229208368256
ko04217	Necroptosis	13/931	178/7206	0.0230172280929
ko04062	Chemokine signaling pathway	37/931	201/7206	0.0244981137168
ko00071	Fatty acid degradation	1/931	45/7206	0.0248386981159
ko03420	Nucleotide excision repair	1/931	46/7206	0.0251025927898
ko04550	Signaling pathways regulating pluripotency of stem cells	12/931	165/7206	0.0255664476394
ko04114	Oocyte meiosis	27/931	139/7206	0.0288967772551
ko04912	GnRH signaling pathway	24/931	122/7206	0.0294061911918
ko03320	PPAR signaling pathway	3/931	69/7206	0.0294204800976
ko05034	Alcoholism	42/931	238/7206	0.0305753709128
ko04932	Non-alcoholic fatty liver disease (NAFLD)	14/931	182/7206	0.032911325497
ko00533	Glycosaminoglycan biosynthesis - keratan sulfate	5/931	15/7206	0.035138311401
ko03022	Basal transcription factors	1/931	44/7206	0.0382477642838
ko05206	MicroRNAs in cancer	14/931	177/7206	0.0413556337385
ko05321	Inflammatory bowel disease (IBD)	2/931	56/7206	0.0420401945578
ko05202	Transcriptional misregulation in cancer	15/931	188/7206	0.0463605242238
ko04658	Th1 and Th2 cell differentiation	6/931	96/7206	0.0467471135352