ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	179/1109	423/7206	2.55287465898e-43
ko04724	Glutamatergic synapse	83/1109	152/7206	1.11692069473e-29
ko05033	Nicotine addiction	45/1109	56/7206	3.27205661544e-27
ko05032	Morphine addiction	66/1109	110/7206	4.95578951014e-27
ko04727	GABAergic synapse	64/1109	110/7206	3.48389075341e-25
ko04728	Dopaminergic synapse	79/1109	185/7206	1.63673004783e-19
ko04713	Circadian entrainment	65/1109	136/7206	2.35453431172e-19
ko04721	Synaptic vesicle cycle	47/1109	80/7206	4.87362988421e-19
ko04024	cAMP signaling pathway	99/1109	279/7206	2.72921288518e-17
ko04725	Cholinergic synapse	68/1109	160/7206	8.20779742514e-17
ko04723	Retrograde endocannabinoid signaling	71/1109	175/7206	3.34992246163e-16
ko04744	Phototransduction	26/1109	36/7206	3.04386867699e-14
ko04921	Oxytocin signaling pathway	76/1109	209/7206	4.99046565841e-14
ko04742	Taste transduction	34/1109	61/7206	3.4005225047e-13
ko04020	Calcium signaling pathway	86/1109	265/7206	1.73873819804e-12
ko04726	Serotonergic synapse	53/1109	137/7206	1.90441299741e-11
ko05031	Amphetamine addiction	39/1109	91/7206	2.5964024267e-10
ko04261	Adrenergic signaling in cardiomyocytes	67/1109	205/7206	3.64410467752e-10
ko04911	Insulin secretion	45/1109	117/7206	8.08708473916e-10
ko03040	Spliceosome	1/1109	145/7206	1.40035162005e-09
ko03010	Ribosome	1/1109	129/7206	1.77822716977e-08
ko04720	Long-term potentiation	37/1109	99/7206	6.33682528999e-08
ko05030	Cocaine addiction	30/1109	73/7206	9.66593360259e-08
ko04966	Collecting duct acid secretion	16/1109	26/7206	1.02811994774e-07
ko05322	Systemic lupus erythematosus	4/1109	151/7206	5.01004496126e-07
ko04970	Salivary secretion	34/1109	95/7206	8.25747122679e-07
ko05203	Viral carcinogenesis	16/1109	277/7206	9.49281859036e-07
ko05168	Herpes simplex infection	7/1109	182/7206	1.05555122492e-06
ko04022	cGMP-PKG signaling pathway	60/1109	216/7206	2.04408734263e-06
ko04925	Aldosterone synthesis and secretion	35/1109	105/7206	3.71227976532e-06
ko05164	Influenza A	7/1109	167/7206	6.14929736452e-06
ko04971	Gastric acid secretion	33/1109	98/7206	6.17303528744e-06
ko03013	RNA transport	8/1109	166/7206	2.75150256619e-05
ko04070	Phosphatidylinositol signaling system	34/1109	112/7206	5.32611852144e-05
ko04740	Olfactory transduction	27/1109	80/7206	5.61061044325e-05
ko04060	Cytokine-cytokine receptor interaction	11/1109	191/7206	5.99599634211e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	25/1109	74/7206	6.75885915208e-05
ko05169	Epstein-Barr virus infection	13/1109	206/7206	7.77593259388e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	26/1109	79/7206	0.000102110926649
ko04010	MAPK signaling pathway	75/1109	321/7206	0.00013188137642
ko04964	Proximal tubule bicarbonate reclamation	13/1109	29/7206	0.000153669249304
ko05162	Measles	5/1109	120/7206	0.000169108140203
ko04745	Phototransduction - fly	15/1109	38/7206	0.00027368514342
ko04514	Cell adhesion molecules (CAMs)	36/1109	130/7206	0.000304372751349
ko05110	Vibrio cholerae infection	21/1109	63/7206	0.000323458669612
ko05161	Hepatitis B	11/1109	173/7206	0.000382741309383
ko04110	Cell cycle	8/1109	145/7206	0.000409098776898
ko03008	Ribosome biogenesis in eukaryotes	2/1109	79/7206	0.000413887925212
ko04371	Apelin signaling pathway	45/1109	177/7206	0.000445243959682
ko04922	Glucagon signaling pathway	35/1109	128/7206	0.000454351068872
ko05140	Leishmaniasis	2/1109	75/7206	0.000595338988252
ko04626	Plant-pathogen interaction	9/1109	18/7206	0.000610234909042
ko04612	Antigen processing and presentation	2/1109	77/7206	0.000632509058084
ko04730	Long-term depression	24/1109	78/7206	0.00068098023793
ko04972	Pancreatic secretion	31/1109	111/7206	0.000753573750523
ko04120	Ubiquitin mediated proteolysis	8/1109	138/7206	0.000754927961055
ko05414	Dilated cardiomyopathy	31/1109	112/7206	0.000809504209767
ko04141	Protein processing in endoplasmic reticulum	13/1109	184/7206	0.000846065652046
ko04976	Bile secretion	24/1109	80/7206	0.000846616401113
ko04072	Phospholipase D signaling pathway	48/1109	197/7206	0.000869954382905
ko04260	Cardiac muscle contraction	28/1109	98/7206	0.000960771644144
ko05410	Hypertrophic cardiomyopathy (HCM)	28/1109	100/7206	0.00112809518986
ko05166	HTLV-I infection	26/1109	292/7206	0.00118071759155
ko04924	Renin secretion	25/1109	86/7206	0.00128071578998
ko04915	Estrogen signaling pathway	34/1109	131/7206	0.00140398123617
ko05205	Proteoglycans in cancer	24/1109	271/7206	0.00189804493089
ko04710	Circadian rhythm	15/1109	43/7206	0.00199976899706
ko00520	Amino sugar and nucleotide sugar metabolism	1/1109	55/7206	0.00209927258509
ko04621	NOD-like receptor signaling pathway	11/1109	157/7206	0.00231592263107
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1109	14/7206	0.00254395042304
ko04961	Endocrine and other factor-regulated calcium reabsorption	18/1109	59/7206	0.00306533812206
ko04014	Ras signaling pathway	61/1109	279/7206	0.00384727386541
ko04064	NF-kappa B signaling pathway	5/1109	96/7206	0.00387772473223
ko04330	Notch signaling pathway	2/1109	62/7206	0.0040870050699
ko04540	Gap junction	32/1109	128/7206	0.00416882622868
ko04214	Apoptosis - fly	3/1109	72/7206	0.00472543834635
ko04510	Focal adhesion	22/1109	240/7206	0.00609291919836
ko03420	Nucleotide excision repair	1/1109	46/7206	0.00692160968025
ko00240	Pyrimidine metabolism	7/1109	110/7206	0.0071039010544
ko04610	Complement and coagulation cascades	4/1109	79/7206	0.00714173468146
ko04360	Axon guidance	51/1109	233/7206	0.00725309074959
ko04750	Inflammatory mediator regulation of TRP channels	30/1109	122/7206	0.0074022604281
ko05219	Bladder cancer	1/1109	48/7206	0.00741461742218
ko05321	Inflammatory bowel disease (IBD)	2/1109	56/7206	0.00865142149539
ko04658	Th1 and Th2 cell differentiation	6/1109	96/7206	0.00978163807867
ko04630	Jak-STAT signaling pathway	10/1109	132/7206	0.0101120007479
ko03022	Basal transcription factors	1/1109	44/7206	0.0104351786433
ko05144	Malaria	1/1109	45/7206	0.0108507976751
ko00480	Glutathione metabolism	2/1109	55/7206	0.0130104682843
ko04115	p53 signaling pathway	4/1109	74/7206	0.0140945199954
ko04923	Regulation of lipolysis in adipocytes	20/1109	77/7206	0.0159391482736
ko05215	Prostate cancer	8/1109	111/7206	0.0160890421718
ko00562	Inositol phosphate metabolism	22/1109	89/7206	0.0180334491644
ko00910	Nitrogen metabolism	7/1109	19/7206	0.0185320428309
ko00590	Arachidonic acid metabolism	2/1109	52/7206	0.0186335600626
ko00330	Arginine and proline metabolism	3/1109	61/7206	0.0193933677346
ko05131	Shigellosis	5/1109	82/7206	0.0195299137128
ko04622	RIG-I-like receptor signaling pathway	3/1109	62/7206	0.0198021827306
ko00010	Glycolysis / Gluconeogenesis	19/1109	74/7206	0.0217928494794
ko03410	Base excision repair	1/1109	38/7206	0.0229383222755
ko04657	IL-17 signaling pathway	6/1109	87/7206	0.024369851383
ko05133	Pertussis	6/1109	87/7206	0.024369851383
ko04210	Apoptosis	17/1109	180/7206	0.027341581001
ko04350	TGF-beta signaling pathway	8/1109	103/7206	0.0276025611171
ko05120	Epithelial cell signaling in Helicobacter pylori infection	22/1109	92/7206	0.0285728281983
ko00680	Methane metabolism	10/1109	34/7206	0.0312559910299
ko05206	MicroRNAs in cancer	17/1109	177/7206	0.0341485199769
ko05145	Toxoplasmosis	11/1109	126/7206	0.0341787775882
ko04930	Type II diabetes mellitus	14/1109	54/7206	0.0374885286037
ko05200	Pathways in cancer	60/1109	492/7206	0.04458866791
ko04217	Necroptosis	18/1109	178/7206	0.0459963851665