ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	193/1200	423/7206	2.17208719871e-47
ko04724	Glutamatergic synapse	90/1200	152/7206	4.05719023999e-33
ko05033	Nicotine addiction	48/1200	56/7206	6.95036472478e-30
ko05032	Morphine addiction	69/1200	110/7206	9.35878015638e-28
ko04727	GABAergic synapse	66/1200	110/7206	5.48474097901e-25
ko04713	Circadian entrainment	74/1200	136/7206	3.35857521641e-24
ko04728	Dopaminergic synapse	83/1200	185/7206	7.28049762226e-20
ko04723	Retrograde endocannabinoid signaling	80/1200	175/7206	8.40962853473e-20
ko04725	Cholinergic synapse	73/1200	160/7206	4.20897224789e-18
ko04721	Synaptic vesicle cycle	47/1200	80/7206	1.31980569089e-17
ko04911	Insulin secretion	57/1200	117/7206	5.49999250635e-16
ko04020	Calcium signaling pathway	96/1200	265/7206	5.16416598755e-15
ko04024	cAMP signaling pathway	99/1200	279/7206	7.32154799951e-15
ko04742	Taste transduction	36/1200	61/7206	7.23273282907e-14
ko04921	Oxytocin signaling pathway	79/1200	209/7206	9.20655538036e-14
ko04726	Serotonergic synapse	58/1200	137/7206	6.84240035175e-13
ko04744	Phototransduction	24/1200	36/7206	2.74782172146e-11
ko05031	Amphetamine addiction	41/1200	91/7206	1.66195674572e-10
ko04720	Long-term potentiation	43/1200	99/7206	2.53360063125e-10
ko03010	Ribosome	1/1200	129/7206	2.51801364905e-09
ko04261	Adrenergic signaling in cardiomyocytes	67/1200	205/7206	1.034916506e-08
ko04970	Salivary secretion	39/1200	95/7206	1.21366466163e-08
ko03040	Spliceosome	3/1200	145/7206	2.47677620335e-08
ko04925	Aldosterone synthesis and secretion	41/1200	105/7206	3.2986250132e-08
ko05322	Systemic lupus erythematosus	5/1200	151/7206	3.80338159824e-07
ko05168	Herpes simplex infection	8/1200	182/7206	4.92012474854e-07
ko04022	cGMP-PKG signaling pathway	65/1200	216/7206	6.17086465359e-07
ko03013	RNA transport	7/1200	166/7206	1.30617058352e-06
ko05203	Viral carcinogenesis	19/1200	277/7206	1.42748314974e-06
ko04971	Gastric acid secretion	36/1200	98/7206	1.4809905388e-06
ko05030	Cocaine addiction	29/1200	73/7206	2.03078308051e-06
ko04740	Olfactory transduction	30/1200	80/7206	5.94760497792e-06
ko04060	Cytokine-cytokine receptor interaction	11/1200	191/7206	7.29086752639e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1200	74/7206	1.0539423809e-05
ko05164	Influenza A	9/1200	167/7206	1.30531207165e-05
ko04360	Axon guidance	65/1200	233/7206	1.42816331655e-05
ko04514	Cell adhesion molecules (CAMs)	41/1200	130/7206	2.32094985281e-05
ko04010	MAPK signaling pathway	82/1200	321/7206	3.17789610222e-05
ko04972	Pancreatic secretion	36/1200	111/7206	4.69461536726e-05
ko04621	NOD-like receptor signaling pathway	9/1200	157/7206	5.06019252259e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1200	79/7206	0.000111807266775
ko04141	Protein processing in endoplasmic reticulum	13/1200	184/7206	0.000178843419107
ko04745	Phototransduction - fly	16/1200	38/7206	0.000180510616098
ko04976	Bile secretion	27/1200	80/7206	0.000198743692547
ko04371	Apelin signaling pathway	49/1200	177/7206	0.000201265417657
ko04110	Cell cycle	9/1200	145/7206	0.000265702829135
ko04710	Circadian rhythm	17/1200	43/7206	0.000285135626062
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	26/1200	79/7206	0.00035786826339
ko04014	Ras signaling pathway	69/1200	279/7206	0.000405233790653
ko04072	Phospholipase D signaling pathway	52/1200	197/7206	0.000438257132076
ko04540	Gap junction	37/1200	128/7206	0.000449670655611
ko05161	Hepatitis B	13/1200	173/7206	0.000585766244231
ko04730	Long-term depression	25/1200	78/7206	0.000666490420723
ko04120	Ubiquitin mediated proteolysis	9/1200	138/7206	0.000709013719256
ko05162	Measles	7/1200	120/7206	0.000716643297606
ko04070	Phosphatidylinositol signaling system	33/1200	112/7206	0.000740573442573
ko04270	Vascular smooth muscle contraction	42/1200	154/7206	0.000917718442708
ko05169	Epstein-Barr virus infection	18/1200	206/7206	0.00119418645523
ko04064	NF-kappa B signaling pathway	5/1200	96/7206	0.00128379185254
ko04630	Jak-STAT signaling pathway	9/1200	132/7206	0.0012977929384
ko04964	Proximal tubule bicarbonate reclamation	12/1200	29/7206	0.00139106191965
ko05140	Leishmaniasis	3/1200	75/7206	0.00150221789209
ko04915	Estrogen signaling pathway	36/1200	131/7206	0.001862734772
ko04924	Renin secretion	26/1200	86/7206	0.00186335118137
ko04750	Inflammatory mediator regulation of TRP channels	34/1200	122/7206	0.00193163012279
ko04922	Glucagon signaling pathway	35/1200	128/7206	0.00248588274071
ko04260	Cardiac muscle contraction	28/1200	98/7206	0.00255270941331
ko05414	Dilated cardiomyopathy	31/1200	112/7206	0.0030067363902
ko05205	Proteoglycans in cancer	28/1200	271/7206	0.00351819491088
ko00071	Fatty acid degradation	1/1200	45/7206	0.00434553781576
ko03420	Nucleotide excision repair	1/1200	46/7206	0.00443521374016
ko04612	Antigen processing and presentation	4/1200	77/7206	0.00493845110175
ko04626	Plant-pathogen interaction	8/1200	18/7206	0.00525252822027
ko00280	Valine, leucine and isoleucine degradation	2/1200	54/7206	0.00561114207627
ko04966	Collecting duct acid secretion	10/1200	26/7206	0.00643560276009
ko03022	Basal transcription factors	1/1200	44/7206	0.00682135659888
ko04115	p53 signaling pathway	4/1200	74/7206	0.00686987602036
ko04961	Endocrine and other factor-regulated calcium reabsorption	18/1200	59/7206	0.00758841977397
ko04217	Necroptosis	17/1200	178/7206	0.00794725193678
ko04916	Melanogenesis	36/1200	142/7206	0.00838946419388
ko04930	Type II diabetes mellitus	17/1200	54/7206	0.00877717799342
ko04622	RIG-I-like receptor signaling pathway	3/1200	62/7206	0.00921943178329
ko04146	Peroxisome	6/1200	89/7206	0.00931203316552
ko04610	Complement and coagulation cascades	5/1200	79/7206	0.00949277991967
ko05166	HTLV-I infection	33/1200	292/7206	0.0126442582319
ko04657	IL-17 signaling pathway	6/1200	87/7206	0.0128937149971
ko05133	Pertussis	6/1200	87/7206	0.0128937149971
ko04912	GnRH signaling pathway	31/1200	122/7206	0.0135522091586
ko05215	Prostate cancer	9/1200	111/7206	0.0139807234099
ko03410	Base excision repair	1/1200	38/7206	0.0147558210834
ko05410	Hypertrophic cardiomyopathy (HCM)	26/1200	100/7206	0.0148785454787
ko05110	Vibrio cholerae infection	18/1200	63/7206	0.0163343437166
ko03018	RNA degradation	6/1200	84/7206	0.0174169177089
ko05219	Bladder cancer	2/1200	48/7206	0.0177487583631
ko05321	Inflammatory bowel disease (IBD)	3/1200	56/7206	0.0184819499137
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1200	14/7206	0.0188975388199
ko04923	Regulation of lipolysis in adipocytes	21/1200	77/7206	0.0196441302675
ko05131	Shigellosis	6/1200	82/7206	0.0239452857313
ko00310	Lysine degradation	5/1200	73/7206	0.0254602874592
ko04210	Apoptosis	19/1200	180/7206	0.0254695244884
ko04640	Hematopoietic cell lineage	4/1200	64/7206	0.0265930670389
ko04658	Th1 and Th2 cell differentiation	8/1200	96/7206	0.026600351513
ko00240	Pyrimidine metabolism	10/1200	110/7206	0.0284705703922
ko03320	PPAR signaling pathway	5/1200	69/7206	0.0339469250499
ko00640	Propanoate metabolism	1/1200	34/7206	0.0340335572522
ko00860	Porphyrin and chlorophyll metabolism	1/1200	34/7206	0.0340335572522
ko01212	Fatty acid metabolism	4/1200	60/7206	0.0358728543341
ko00590	Arachidonic acid metabolism	3/1200	52/7206	0.0375792547437
ko05220	Chronic myeloid leukemia	7/1200	85/7206	0.0390138458773
ko04918	Thyroid hormone synthesis	22/1200	86/7206	0.03981940718
ko00230	Purine metabolism	43/1200	194/7206	0.0402417240248
ko04620	Toll-like receptor signaling pathway	9/1200	100/7206	0.0415413823483
ko01524	Platinum drug resistance	6/1200	76/7206	0.0427522420561
ko04932	Non-alcoholic fatty liver disease (NAFLD)	20/1200	182/7206	0.0431066069006
ko04670	Leukocyte transendothelial migration	16/1200	151/7206	0.0462926876353
ko04142	Lysosome	16/1200	151/7206	0.0462926876353