ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	151/755	423/7206	2.3023656837e-47
ko05033	Nicotine addiction	42/755	56/7206	3.46471950833e-30
ko04724	Glutamatergic synapse	69/755	152/7206	6.75241292624e-29
ko04727	GABAergic synapse	50/755	110/7206	3.23093444143e-21
ko05032	Morphine addiction	50/755	110/7206	3.23093444143e-21
ko04728	Dopaminergic synapse	65/755	185/7206	6.85394981038e-20
ko04723	Retrograde endocannabinoid signaling	61/755	175/7206	1.58348787783e-18
ko04713	Circadian entrainment	52/755	136/7206	5.95808398298e-18
ko04721	Synaptic vesicle cycle	38/755	80/7206	3.28451652911e-17
ko04024	cAMP signaling pathway	76/755	279/7206	7.79770300061e-16
ko04725	Cholinergic synapse	53/755	160/7206	3.69239150806e-15
ko04020	Calcium signaling pathway	71/755	265/7206	1.8960606492e-14
ko04911	Insulin secretion	42/755	117/7206	1.30142548612e-13
ko05031	Amphetamine addiction	35/755	91/7206	1.44864536395e-12
ko04726	Serotonergic synapse	43/755	137/7206	1.23692694359e-11
ko04921	Oxytocin signaling pathway	55/755	209/7206	4.21183812964e-11
ko05030	Cocaine addiction	28/755	73/7206	2.80188700118e-10
ko04720	Long-term potentiation	33/755	99/7206	5.47170484619e-10
ko04261	Adrenergic signaling in cardiomyocytes	51/755	205/7206	1.99869328514e-09
ko04742	Taste transduction	23/755	61/7206	1.64114349791e-08
ko04972	Pancreatic secretion	32/755	111/7206	5.40238092789e-08
ko04970	Salivary secretion	29/755	95/7206	5.73100089243e-08
ko05203	Viral carcinogenesis	7/755	277/7206	6.00744829781e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	23/755	74/7206	9.53836092185e-07
ko04925	Aldosterone synthesis and secretion	28/755	105/7206	2.08770210527e-06
ko03040	Spliceosome	1/755	145/7206	3.1456947069e-06
ko04060	Cytokine-cytokine receptor interaction	4/755	191/7206	1.15135870425e-05
ko04971	Gastric acid secretion	25/755	98/7206	1.69934371029e-05
ko05164	Influenza A	3/755	167/7206	1.80948412703e-05
ko04010	MAPK signaling pathway	58/755	321/7206	2.347140882e-05
ko04966	Collecting duct acid secretion	11/755	26/7206	2.73302344545e-05
ko04022	cGMP-PKG signaling pathway	43/755	216/7206	3.61285356357e-05
ko04120	Ubiquitin mediated proteolysis	2/755	138/7206	5.80204981596e-05
ko05169	Epstein-Barr virus infection	6/755	206/7206	6.81765904837e-05
ko04730	Long-term depression	20/755	78/7206	0.000108199162983
ko04110	Cell cycle	3/755	145/7206	0.000167565534522
ko05110	Vibrio cholerae infection	17/755	63/7206	0.000179730478464
ko04141	Protein processing in endoplasmic reticulum	6/755	184/7206	0.000362024697819
ko05162	Measles	2/755	120/7206	0.000402347820521
ko05322	Systemic lupus erythematosus	4/755	151/7206	0.000413992408328
ko04514	Cell adhesion molecules (CAMs)	27/755	130/7206	0.000422639527507
ko05168	Herpes simplex infection	6/755	182/7206	0.000508251833031
ko04924	Renin secretion	20/755	86/7206	0.000514345270543
ko04260	Cardiac muscle contraction	22/755	98/7206	0.000626998653087
ko04072	Phospholipase D signaling pathway	36/755	197/7206	0.000830135584781
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	18/755	79/7206	0.0012444282412
ko04915	Estrogen signaling pathway	26/755	131/7206	0.00126946459939
ko04070	Phosphatidylinositol signaling system	23/755	112/7206	0.00150095846212
ko04350	TGF-beta signaling pathway	2/755	103/7206	0.00172014632553
ko04550	Signaling pathways regulating pluripotency of stem cells	6/755	165/7206	0.00183641085636
ko04750	Inflammatory mediator regulation of TRP channels	24/755	122/7206	0.0023959557725
ko05166	HTLV-I infection	16/755	292/7206	0.00324294091341
ko04961	Endocrine and other factor-regulated calcium reabsorption	14/755	59/7206	0.00395701300741
ko03013	RNA transport	7/755	166/7206	0.00461299015213
ko04976	Bile secretion	17/755	80/7206	0.00470487333961
ko04978	Mineral absorption	10/755	40/7206	0.00686730089832
ko05414	Dilated cardiomyopathy	21/755	112/7206	0.00744490452007
ko04964	Proximal tubule bicarbonate reclamation	8/755	29/7206	0.00811889426935
ko04540	Gap junction	23/755	128/7206	0.00839078580806
ko05120	Epithelial cell signaling in Helicobacter pylori infection	18/755	92/7206	0.00885832294024
ko05205	Proteoglycans in cancer	16/755	271/7206	0.0110703142306
ko00604	Glycosphingolipid biosynthesis - ganglio series	5/755	14/7206	0.0111360275867
ko04621	NOD-like receptor signaling pathway	7/755	157/7206	0.011471255138
ko05215	Prostate cancer	4/755	111/7206	0.0120219816909
ko05410	Hypertrophic cardiomyopathy (HCM)	19/755	100/7206	0.0121962635566
ko04140	Autophagy - animal	8/755	164/7206	0.0139650017099
ko04745	Phototransduction - fly	9/755	38/7206	0.0145225107789
ko03008	Ribosome biogenesis in eukaryotes	2/755	79/7206	0.0150918180277
ko05202	Transcriptional misregulation in cancer	10/755	188/7206	0.0155878883133
ko05200	Pathways in cancer	36/755	492/7206	0.0177965018474
ko04330	Notch signaling pathway	1/755	62/7206	0.0191445043965
ko04918	Thyroid hormone synthesis	16/755	86/7206	0.0199931742698
ko00680	Methane metabolism	8/755	34/7206	0.0215195316377
ko04612	Antigen processing and presentation	2/755	77/7206	0.0223194632097
ko04210	Apoptosis	10/755	180/7206	0.0261449875539
ko00480	Glutathione metabolism	1/755	55/7206	0.0267539875655
ko04014	Ras signaling pathway	41/755	279/7206	0.0275744012982
ko04214	Apoptosis - fly	2/755	72/7206	0.0309352626671
ko04510	Focal adhesion	15/755	240/7206	0.0312546235143
ko00310	Lysine degradation	2/755	73/7206	0.0316284659603
ko04626	Plant-pathogen interaction	5/755	18/7206	0.0335251818991
ko05323	Rheumatoid arthritis	16/755	89/7206	0.033929451185
ko04973	Carbohydrate digestion and absorption	9/755	42/7206	0.0366982099228
ko04710	Circadian rhythm	9/755	43/7206	0.0398325521321
ko05034	Alcoholism	35/755	238/7206	0.039917402098
ko04064	NF-kappa B signaling pathway	4/755	96/7206	0.0425330109486
ko05161	Hepatitis B	10/755	173/7206	0.0433512228303
ko05224	Breast cancer	10/755	174/7206	0.0436897763683
ko05217	Basal cell carcinoma	2/755	68/7206	0.0437495996344
ko04270	Vascular smooth muscle contraction	24/755	154/7206	0.0449546339956
ko04932	Non-alcoholic fatty liver disease (NAFLD)	11/755	182/7206	0.0491603649402