ko pathway ratio_in_study ratio_in_pop p_value ko01200 Carbon metabolism 31/569 128/7206 9.78809393577e-09 ko00010 Glycolysis / Gluconeogenesis 22/569 74/7206 2.71953719572e-08 ko00350 Tyrosine metabolism 12/569 33/7206 3.96762413033e-06 ko03320 PPAR signaling pathway 18/569 69/7206 4.13293260876e-06 ko00071 Fatty acid degradation 14/569 45/7206 5.23911596481e-06 ko04922 Glucagon signaling pathway 26/569 128/7206 5.60527515036e-06 ko00620 Pyruvate metabolism 14/569 46/7206 6.99333366089e-06 ko01230 Biosynthesis of amino acids 19/569 85/7206 2.52351324556e-05 ko00643 Styrene degradation 4/569 4/7206 3.84985817061e-05 ko00500 Starch and sucrose metabolism 11/569 35/7206 4.88142953701e-05 ko00120 Primary bile acid biosynthesis 8/569 20/7206 7.71747636958e-05 ko00020 Citrate cycle (TCA cycle) 10/569 35/7206 0.000260975457809 ko04610 Complement and coagulation cascades 16/569 79/7206 0.000366623823608 ko03010 Ribosome 1/569 129/7206 0.000436587393731 ko00362 Benzoate degradation 4/569 6/7206 0.000507358716778 ko04020 Calcium signaling pathway 37/569 265/7206 0.000650905031542 ko00052 Galactose metabolism 9/569 33/7206 0.000771193763529 ko04260 Cardiac muscle contraction 18/569 98/7206 0.000865135531365 ko03040 Spliceosome 2/569 145/7206 0.000925737991698 ko00640 Propanoate metabolism 9/569 34/7206 0.000976694644573 ko04933 AGE-RAGE signaling pathway in diabetic complications 22/569 135/7206 0.000988851030064 ko00360 Phenylalanine metabolism 6/569 17/7206 0.00137262730578 ko04710 Circadian rhythm 10/569 43/7206 0.00153339686765 ko04974 Protein digestion and absorption 17/569 96/7206 0.00157764338797 ko00960 Tropane, piperidine and pyridine alkaloid biosynthesis 3/569 4/7206 0.00184425891235 ko04022 cGMP-PKG signaling pathway 30/569 216/7206 0.00196581048245 ko04120 Ubiquitin mediated proteolysis 2/569 138/7206 0.00199811808881 ko04146 Peroxisome 16/569 89/7206 0.00206446434831 ko04261 Adrenergic signaling in cardiomyocytes 29/569 205/7206 0.00217391104846 ko01212 Fatty acid metabolism 12/569 60/7206 0.00217724997429 ko04152 AMPK signaling pathway 24/569 161/7206 0.00261324065151 ko04066 HIF-1 signaling pathway 19/569 123/7206 0.00382328504967 ko00680 Methane metabolism 8/569 34/7206 0.00414399493712 ko04110 Cell cycle 3/569 145/7206 0.00461124302911 ko04512 ECM-receptor interaction 14/569 79/7206 0.00464982968212 ko00051 Fructose and mannose metabolism 9/569 42/7206 0.00470714159997 ko05230 Central carbon metabolism in cancer 14/569 81/7206 0.00527919496595 ko00950 Isoquinoline alkaloid biosynthesis 4/569 10/7206 0.00549488801063 ko05410 Hypertrophic cardiomyopathy (HCM) 16/569 100/7206 0.00731232084416 ko05010 Alzheimer's disease 27/569 202/7206 0.00740901254759 ko00720 Carbon fixation pathways in prokaryotes 5/569 17/7206 0.0083904083989 ko00630 Glyoxylate and dicarboxylate metabolism 8/569 38/7206 0.00844281258778 ko04614 Renin-angiotensin system 5/569 18/7206 0.0108777983078 ko00030 Pentose phosphate pathway 7/569 32/7206 0.0108929297794 ko05203 Viral carcinogenesis 11/569 277/7206 0.0118673503858 ko04921 Oxytocin signaling pathway 27/569 209/7206 0.012489653258 ko03013 RNA transport 5/569 166/7206 0.0129854999752 ko00140 Steroid hormone biosynthesis 8/569 41/7206 0.0133919037324 ko05322 Systemic lupus erythematosus 4/569 151/7206 0.0134302354256 ko00592 alpha-Linolenic acid metabolism 5/569 19/7206 0.0138249371265 ko05034 Alcoholism 9/569 238/7206 0.0139447132282 ko04270 Vascular smooth muscle contraction 21/569 154/7206 0.0142967982521 ko00380 Tryptophan metabolism 9/569 50/7206 0.0150659401134 ko00710 Carbon fixation in photosynthetic organisms 6/569 27/7206 0.0166889485355 ko04510 Focal adhesion 29/569 240/7206 0.0200104968238 ko05150 Staphylococcus aureus infection 7/569 36/7206 0.0205562730406 ko05144 Malaria 8/569 45/7206 0.02291085332 ko00982 Drug metabolism - cytochrome P450 7/569 37/7206 0.0236852739771 ko00330 Arginine and proline metabolism 10/569 61/7206 0.0265353536792 ko04068 FoxO signaling pathway 21/569 167/7206 0.028999744353 ko00561 Glycerolipid metabolism 10/569 63/7206 0.0301809469002 ko04976 Bile secretion 12/569 80/7206 0.0328364505225 ko04930 Type II diabetes mellitus 9/569 54/7206 0.0357579810099 ko00280 Valine, leucine and isoleucine degradation 9/569 54/7206 0.0357579810099 ko01040 Biosynthesis of unsaturated fatty acids 5/569 25/7206 0.0427520479724 ko00230 Purine metabolism 23/569 194/7206 0.0429215270629 ko04925 Aldosterone synthesis and secretion 14/569 105/7206 0.0444149055766 ko04111 Cell cycle - yeast 2/569 90/7206 0.046325563568 ko04391 Hippo signaling pathway - fly 2/569 90/7206 0.046325563568 ko05414 Dilated cardiomyopathy 15/569 112/7206 0.048757061943 ko04932 Non-alcoholic fatty liver disease (NAFLD) 22/569 182/7206 0.0493287165839 ko00040 Pentose and glucuronate interconversions 5/569 26/7206 0.0496260765205