ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	201/1259	423/7206	2.14044724961e-49
ko04724	Glutamatergic synapse	89/1259	152/7206	1.41532906227e-30
ko05033	Nicotine addiction	47/1259	56/7206	1.77075333759e-27
ko05032	Morphine addiction	70/1259	110/7206	2.22558765705e-27
ko04727	GABAergic synapse	68/1259	110/7206	1.55283669615e-25
ko04713	Circadian entrainment	77/1259	136/7206	2.9556433949e-25
ko04725	Cholinergic synapse	80/1259	160/7206	1.58854391569e-21
ko04728	Dopaminergic synapse	85/1259	185/7206	9.54102363901e-20
ko04723	Retrograde endocannabinoid signaling	79/1259	175/7206	7.32906584383e-18
ko04742	Taste transduction	41/1259	61/7206	8.27436270468e-18
ko04721	Synaptic vesicle cycle	48/1259	80/7206	1.33798247345e-17
ko04744	Phototransduction	29/1259	36/7206	1.91468939118e-16
ko04024	cAMP signaling pathway	105/1259	279/7206	3.65275984435e-16
ko04911	Insulin secretion	58/1259	117/7206	1.05995739544e-15
ko04020	Calcium signaling pathway	99/1259	265/7206	4.69027742706e-15
ko04726	Serotonergic synapse	61/1259	137/7206	1.00290892528e-13
ko04921	Oxytocin signaling pathway	80/1259	209/7206	3.86078578099e-13
ko04740	Olfactory transduction	41/1259	80/7206	4.42528617446e-12
ko04261	Adrenergic signaling in cardiomyocytes	74/1259	205/7206	1.27278980376e-10
ko05031	Amphetamine addiction	42/1259	91/7206	1.84834740914e-10
ko03040	Spliceosome	2/1259	145/7206	5.96058639728e-10
ko04970	Salivary secretion	42/1259	95/7206	9.72636112571e-10
ko04720	Long-term potentiation	43/1259	99/7206	1.21085882414e-09
ko04971	Gastric acid secretion	42/1259	98/7206	3.09716484426e-09
ko04925	Aldosterone synthesis and secretion	43/1259	105/7206	1.21649575519e-08
ko03013	RNA transport	6/1259	166/7206	6.63890086084e-08
ko05203	Viral carcinogenesis	18/1259	277/7206	7.21033929485e-08
ko05168	Herpes simplex infection	8/1259	182/7206	9.99729071389e-08
ko05322	Systemic lupus erythematosus	5/1259	151/7206	1.04815159048e-07
ko04745	Phototransduction - fly	20/1259	38/7206	8.3312413244e-07
ko04022	cGMP-PKG signaling pathway	67/1259	216/7206	9.87479011733e-07
ko04972	Pancreatic secretion	40/1259	111/7206	3.07772672862e-06
ko04360	Axon guidance	69/1259	233/7206	3.91085484995e-06
ko04966	Collecting duct acid secretion	15/1259	26/7206	4.47398882943e-06
ko04621	NOD-like receptor signaling pathway	8/1259	157/7206	5.59806075434e-06
ko05030	Cocaine addiction	29/1259	73/7206	6.25134014229e-06
ko04010	MAPK signaling pathway	87/1259	321/7206	1.11552264399e-05
ko05164	Influenza A	10/1259	167/7206	1.80099951219e-05
ko04141	Protein processing in endoplasmic reticulum	12/1259	184/7206	1.85487027044e-05
ko04120	Ubiquitin mediated proteolysis	7/1259	138/7206	2.06900724852e-05
ko04060	Cytokine-cytokine receptor interaction	13/1259	191/7206	2.61374215494e-05
ko04750	Inflammatory mediator regulation of TRP channels	40/1259	122/7206	3.26165967932e-05
ko04514	Cell adhesion molecules (CAMs)	42/1259	130/7206	3.33731821944e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1259	74/7206	3.38950182394e-05
ko04014	Ras signaling pathway	76/1259	279/7206	3.58357952874e-05
ko04924	Renin secretion	31/1259	86/7206	3.81603882807e-05
ko04976	Bile secretion	29/1259	80/7206	4.64420736431e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1259	79/7206	7.03252353277e-05
ko04730	Long-term depression	28/1259	78/7206	0.000115350357854
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1259	79/7206	0.000129285503724
ko04070	Phosphatidylinositol signaling system	36/1259	112/7206	0.000133719502761
ko05140	Leishmaniasis	2/1259	75/7206	0.000163718036083
ko05169	Epstein-Barr virus infection	17/1259	206/7206	0.000177095592099
ko04540	Gap junction	39/1259	128/7206	0.000242817931084
ko05110	Vibrio cholerae infection	23/1259	63/7206	0.000306902118765
ko04110	Cell cycle	10/1259	145/7206	0.000346510063821
ko05414	Dilated cardiomyopathy	35/1259	112/7206	0.000360171137894
ko04072	Phospholipase D signaling pathway	54/1259	197/7206	0.000400797700348
ko04064	NF-kappa B signaling pathway	5/1259	96/7206	0.000596429268533
ko04612	Antigen processing and presentation	3/1259	77/7206	0.000694512968657
ko05162	Measles	8/1259	120/7206	0.00092377303202
ko05205	Proteoglycans in cancer	28/1259	271/7206	0.00106395112765
ko05161	Hepatitis B	15/1259	173/7206	0.00113334658762
ko04260	Cardiac muscle contraction	30/1259	98/7206	0.00118903765646
ko05166	HTLV-I infection	31/1259	292/7206	0.00119895310116
ko04371	Apelin signaling pathway	48/1259	177/7206	0.00123415982202
ko04923	Regulation of lipolysis in adipocytes	25/1259	77/7206	0.00127260155409
ko04626	Plant-pathogen interaction	9/1259	18/7206	0.00157966921708
ko04146	Peroxisome	5/1259	89/7206	0.00172011455716
ko04964	Proximal tubule bicarbonate reclamation	12/1259	29/7206	0.00213764489005
ko04915	Estrogen signaling pathway	37/1259	131/7206	0.00229058314583
ko04657	IL-17 signaling pathway	5/1259	87/7206	0.00246594843771
ko00071	Fatty acid degradation	1/1259	45/7206	0.0027647681688
ko03420	Nucleotide excision repair	1/1259	46/7206	0.00278987214432
ko00280	Valine, leucine and isoleucine degradation	2/1259	54/7206	0.0036641363852
ko04270	Vascular smooth muscle contraction	41/1259	154/7206	0.00369310275334
ko03022	Basal transcription factors	1/1259	44/7206	0.00427514833346
ko04214	Apoptosis - fly	4/1259	72/7206	0.00458012308382
ko00590	Arachidonic acid metabolism	2/1259	52/7206	0.00538344840562
ko00330	Arginine and proline metabolism	3/1259	61/7206	0.00613062592057
ko05016	Huntington's disease	23/1259	215/7206	0.00617035148226
ko04622	RIG-I-like receptor signaling pathway	3/1259	62/7206	0.00628641646818
ko04610	Complement and coagulation cascades	5/1259	79/7206	0.00666482274222
ko04217	Necroptosis	18/1259	178/7206	0.00686657702421
ko04710	Circadian rhythm	15/1259	43/7206	0.00712557732285
ko05410	Hypertrophic cardiomyopathy (HCM)	28/1259	100/7206	0.00772317245916
ko05145	Toxoplasmosis	11/1259	126/7206	0.00867726689083
ko05217	Basal cell carcinoma	4/1259	68/7206	0.00930724036992
ko04922	Glucagon signaling pathway	34/1259	128/7206	0.00934943164745
ko04015	Rap1 signaling pathway	65/1259	278/7206	0.00988814965126
ko04930	Type II diabetes mellitus	17/1259	54/7206	0.0108091170626
ko05219	Bladder cancer	2/1259	48/7206	0.0117320660018
ko05131	Shigellosis	6/1259	82/7206	0.012274090306
ko05321	Inflammatory bowel disease (IBD)	3/1259	56/7206	0.0125889509379
ko00310	Lysine degradation	5/1259	73/7206	0.0127145589132
ko04961	Endocrine and other factor-regulated calcium reabsorption	18/1259	59/7206	0.0144199271141
ko04658	Th1 and Th2 cell differentiation	8/1259	96/7206	0.0145530780546
ko05133	Pertussis	7/1259	87/7206	0.0157185258919
ko04932	Non-alcoholic fatty liver disease (NAFLD)	20/1259	182/7206	0.0175422198406
ko00640	Propanoate metabolism	1/1259	34/7206	0.02150413918
ko00860	Porphyrin and chlorophyll metabolism	1/1259	34/7206	0.02150413918
ko00500	Starch and sucrose metabolism	1/1259	35/7206	0.0224405282812
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1259	14/7206	0.0236623430722
ko03018	RNA degradation	7/1259	84/7206	0.0288224769987
ko04912	GnRH signaling pathway	31/1259	122/7206	0.0294364624338
ko04210	Apoptosis	21/1259	180/7206	0.0367768733014
ko04630	Jak-STAT signaling pathway	14/1259	132/7206	0.0367814862081
ko00240	Pyrimidine metabolism	11/1259	110/7206	0.0418527094043
ko04916	Melanogenesis	34/1259	142/7206	0.0445112982486
ko05206	MicroRNAs in cancer	21/1259	177/7206	0.0452265957446
ko04640	Hematopoietic cell lineage	5/1259	64/7206	0.0455214772925
ko04620	Toll-like receptor signaling pathway	10/1259	100/7206	0.0466969948522
ko00562	Inositol phosphate metabolism	23/1259	89/7206	0.0478115677873
ko05320	Autoimmune thyroid disease	1/1259	29/7206	0.0478536851546
ko00480	Glutathione metabolism	4/1259	55/7206	0.0485046091797