ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	192/1175	423/7206	3.35574557112e-48
ko04724	Glutamatergic synapse	86/1175	152/7206	2.3875905336e-30
ko05033	Nicotine addiction	46/1175	56/7206	1.84547715036e-27
ko05032	Morphine addiction	64/1175	110/7206	9.57592522584e-24
ko04713	Circadian entrainment	72/1175	136/7206	3.44395934224e-23
ko04727	GABAergic synapse	62/1175	110/7206	5.011478069e-22
ko04728	Dopaminergic synapse	82/1175	185/7206	7.96951196597e-20
ko04721	Synaptic vesicle cycle	48/1175	80/7206	7.05513070896e-19
ko04725	Cholinergic synapse	73/1175	160/7206	1.23159444405e-18
ko04020	Calcium signaling pathway	99/1175	265/7206	2.68710372023e-17
ko04723	Retrograde endocannabinoid signaling	74/1175	175/7206	1.33685126733e-16
ko04024	cAMP signaling pathway	100/1175	279/7206	4.90637120021e-16
ko04911	Insulin secretion	55/1175	117/7206	5.01558284386e-15
ko04726	Serotonergic synapse	58/1175	137/7206	2.70009121447e-13
ko04742	Taste transduction	35/1175	61/7206	2.72991640776e-13
ko04921	Oxytocin signaling pathway	77/1175	209/7206	2.81160766129e-13
ko04970	Salivary secretion	44/1175	95/7206	5.33375271753e-12
ko04261	Adrenergic signaling in cardiomyocytes	71/1175	205/7206	7.26576430607e-11
ko05031	Amphetamine addiction	41/1175	91/7206	8.44513798435e-11
ko04720	Long-term potentiation	41/1175	99/7206	1.96951437858e-09
ko03040	Spliceosome	2/1175	145/7206	4.06790355472e-09
ko03010	Ribosome	1/1175	129/7206	4.10263300775e-09
ko05203	Viral carcinogenesis	14/1175	277/7206	9.8359985352e-09
ko04744	Phototransduction	21/1175	36/7206	1.1417553011e-08
ko04925	Aldosterone synthesis and secretion	39/1175	105/7206	1.7519732394e-07
ko04971	Gastric acid secretion	37/1175	98/7206	2.38740351577e-07
ko05168	Herpes simplex infection	8/1175	182/7206	7.32989576378e-07
ko04022	cGMP-PKG signaling pathway	64/1175	216/7206	7.72048291407e-07
ko04360	Axon guidance	67/1175	233/7206	1.27326521317e-06
ko04740	Olfactory transduction	31/1175	80/7206	1.67186412895e-06
ko03013	RNA transport	7/1175	166/7206	1.89724859186e-06
ko05322	Systemic lupus erythematosus	6/1175	151/7206	3.31189399073e-06
ko04060	Cytokine-cytokine receptor interaction	10/1175	191/7206	3.66485593036e-06
ko04621	NOD-like receptor signaling pathway	7/1175	157/7206	5.54921802766e-06
ko04514	Cell adhesion molecules (CAMs)	42/1175	130/7206	5.73596766947e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1175	74/7206	7.86910229335e-06
ko04972	Pancreatic secretion	37/1175	111/7206	1.14449580752e-05
ko04966	Collecting duct acid secretion	14/1175	26/7206	1.20779711491e-05
ko04070	Phosphatidylinositol signaling system	37/1175	112/7206	1.26604883193e-05
ko05030	Cocaine addiction	27/1175	73/7206	1.6676191106e-05
ko04730	Long-term depression	28/1175	78/7206	2.03011102934e-05
ko04120	Ubiquitin mediated proteolysis	6/1175	138/7206	2.052726019e-05
ko05164	Influenza A	9/1175	167/7206	2.73271504231e-05
ko04110	Cell cycle	7/1175	145/7206	3.29897371731e-05
ko04745	Phototransduction - fly	17/1175	38/7206	3.38550523154e-05
ko04750	Inflammatory mediator regulation of TRP channels	38/1175	122/7206	3.56067766611e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1175	79/7206	3.74296512647e-05
ko05169	Epstein-Barr virus infection	14/1175	206/7206	5.15119893238e-05
ko04010	MAPK signaling pathway	80/1175	321/7206	5.22232071391e-05
ko04540	Gap junction	39/1175	128/7206	5.25558915912e-05
ko05110	Vibrio cholerae infection	23/1175	63/7206	9.12385883376e-05
ko04976	Bile secretion	27/1175	80/7206	0.000104109525228
ko04260	Cardiac muscle contraction	31/1175	98/7206	0.000149842167962
ko03008	Ribosome biogenesis in eukaryotes	2/1175	79/7206	0.00017159569126
ko04924	Renin secretion	28/1175	86/7206	0.00017546433948
ko04710	Circadian rhythm	17/1175	43/7206	0.000219561426815
ko05414	Dilated cardiomyopathy	34/1175	112/7206	0.00023681499367
ko04141	Protein processing in endoplasmic reticulum	13/1175	184/7206	0.000244502199941
ko04072	Phospholipase D signaling pathway	52/1175	197/7206	0.000262318977918
ko05161	Hepatitis B	13/1175	173/7206	0.000796530239232
ko04610	Complement and coagulation cascades	3/1175	79/7206	0.00105298272063
ko05166	HTLV-I infection	28/1175	292/7206	0.00114907675809
ko04964	Proximal tubule bicarbonate reclamation	12/1175	29/7206	0.00114915929117
ko05140	Leishmaniasis	3/1175	75/7206	0.00150194062646
ko04612	Antigen processing and presentation	3/1175	77/7206	0.00156168391952
ko04630	Jak-STAT signaling pathway	9/1175	132/7206	0.00179871149546
ko05205	Proteoglycans in cancer	26/1175	271/7206	0.00182752717696
ko04064	NF-kappa B signaling pathway	5/1175	96/7206	0.00188951489692
ko05410	Hypertrophic cardiomyopathy (HCM)	28/1175	100/7206	0.00258213095765
ko04330	Notch signaling pathway	2/1175	62/7206	0.00272545516395
ko05219	Bladder cancer	1/1175	48/7206	0.00295239968669
ko04146	Peroxisome	5/1175	89/7206	0.00357069630956
ko04014	Ras signaling pathway	64/1175	279/7206	0.00366496366109
ko03420	Nucleotide excision repair	1/1175	46/7206	0.0044224828294
ko04626	Plant-pathogen interaction	8/1175	18/7206	0.00459533366989
ko04960	Aldosterone-regulated sodium reabsorption	14/1175	41/7206	0.00463127997527
ko04657	IL-17 signaling pathway	5/1175	87/7206	0.00502545732293
ko04217	Necroptosis	16/1175	178/7206	0.00544712723422
ko05321	Inflammatory bowel disease (IBD)	2/1175	56/7206	0.005714162047
ko05162	Measles	9/1175	120/7206	0.00591311842153
ko05016	Huntington's disease	21/1175	215/7206	0.00650077816615
ko03022	Basal transcription factors	1/1175	44/7206	0.00668565214836
ko00071	Fatty acid degradation	1/1175	45/7206	0.00696239903118
ko04915	Estrogen signaling pathway	33/1175	131/7206	0.00826204473174
ko04622	RIG-I-like receptor signaling pathway	3/1175	62/7206	0.00925068038594
ko04214	Apoptosis - fly	4/1175	72/7206	0.00964411219347
ko00310	Lysine degradation	4/1175	73/7206	0.00983083089833
ko04658	Th1 and Th2 cell differentiation	7/1175	96/7206	0.0121649221342
ko00590	Arachidonic acid metabolism	2/1175	52/7206	0.012583413591
ko05133	Pertussis	6/1175	87/7206	0.0128314845226
ko04961	Endocrine and other factor-regulated calcium reabsorption	17/1175	59/7206	0.0130324383865
ko04930	Type II diabetes mellitus	16/1175	54/7206	0.0144163146446
ko03410	Base excision repair	1/1175	38/7206	0.0149025968667
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1175	14/7206	0.0171042403361
ko04371	Apelin signaling pathway	41/1175	177/7206	0.0172941407617
ko05220	Chronic myeloid leukemia	6/1175	85/7206	0.0174729540483
ko04973	Carbohydrate digestion and absorption	13/1175	42/7206	0.0184953153013
ko04140	Autophagy - animal	16/1175	164/7206	0.0186571587409
ko04932	Non-alcoholic fatty liver disease (NAFLD)	18/1175	182/7206	0.0188419034978
ko05215	Prostate cancer	9/1175	111/7206	0.0188456147517
ko05145	Toxoplasmosis	11/1175	126/7206	0.0200603472718
ko04922	Glucagon signaling pathway	31/1175	128/7206	0.0209770118547
ko05131	Shigellosis	6/1175	82/7206	0.0236471784148
ko05144	Malaria	2/1175	45/7206	0.0254612041633
ko00280	Valine, leucine and isoleucine degradation	3/1175	54/7206	0.026502225025
ko04923	Regulation of lipolysis in adipocytes	20/1175	77/7206	0.028685516877
ko01200	Carbon metabolism	12/1175	128/7206	0.0297042032314
ko05200	Pathways in cancer	63/1175	492/7206	0.0313750317651
ko00860	Porphyrin and chlorophyll metabolism	1/1175	34/7206	0.0334923762436
ko04113	Meiosis - yeast	5/1175	70/7206	0.0342553353568
ko04912	GnRH signaling pathway	29/1175	122/7206	0.0344966384392
ko04270	Vascular smooth muscle contraction	35/1175	154/7206	0.0355978969835
ko00240	Pyrimidine metabolism	10/1175	110/7206	0.0372833143152
ko05231	Choline metabolism in cancer	31/1175	134/7206	0.0436835251456
ko04711	Circadian rhythm - fly	5/1175	13/7206	0.0469405868471