ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	166/981	423/7206	2.41383290706e-42
ko04724	Glutamatergic synapse	78/981	152/7206	3.13697052685e-29
ko05033	Nicotine addiction	44/981	56/7206	3.63263721807e-28
ko04721	Synaptic vesicle cycle	50/981	80/7206	2.4498636166e-24
ko04713	Circadian entrainment	66/981	136/7206	4.2816839409e-23
ko04728	Dopaminergic synapse	78/981	185/7206	3.08444450137e-22
ko05032	Morphine addiction	57/981	110/7206	6.91995321193e-22
ko04727	GABAergic synapse	55/981	110/7206	3.34757416564e-20
ko04725	Cholinergic synapse	67/981	160/7206	4.81818018653e-19
ko04723	Retrograde endocannabinoid signaling	68/981	175/7206	3.06040003131e-17
ko04024	cAMP signaling pathway	87/981	279/7206	8.66694350378e-15
ko04742	Taste transduction	32/981	61/7206	5.07312309776e-13
ko04726	Serotonergic synapse	52/981	137/7206	5.55597647668e-13
ko04911	Insulin secretion	46/981	117/7206	2.90137136414e-12
ko04020	Calcium signaling pathway	79/981	265/7206	3.10893579473e-12
ko04921	Oxytocin signaling pathway	67/981	209/7206	3.88023357183e-12
ko04744	Phototransduction	22/981	36/7206	4.05553546798e-11
ko04261	Adrenergic signaling in cardiomyocytes	63/981	205/7206	1.30404173086e-10
ko04720	Long-term potentiation	38/981	99/7206	5.34012376882e-10
ko05031	Amphetamine addiction	36/981	91/7206	5.7080320316e-10
ko03040	Spliceosome	1/981	145/7206	2.32428347478e-08
ko05203	Viral carcinogenesis	11/981	277/7206	8.70269453718e-08
ko04970	Salivary secretion	33/981	95/7206	1.25882438092e-07
ko04966	Collecting duct acid secretion	15/981	26/7206	1.64344743203e-07
ko04120	Ubiquitin mediated proteolysis	2/981	138/7206	5.53863096499e-07
ko05168	Herpes simplex infection	5/981	182/7206	8.46291915895e-07
ko05164	Influenza A	4/981	167/7206	9.11913608366e-07
ko04740	Olfactory transduction	28/981	80/7206	9.49366852465e-07
ko05030	Cocaine addiction	26/981	73/7206	1.58289052876e-06
ko04925	Aldosterone synthesis and secretion	33/981	105/7206	1.91087386012e-06
ko04971	Gastric acid secretion	31/981	98/7206	3.57010676721e-06
ko04060	Cytokine-cytokine receptor interaction	7/981	191/7206	5.16696835805e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	25/981	74/7206	7.46456154904e-06
ko04010	MAPK signaling pathway	72/981	321/7206	1.22989813638e-05
ko04621	NOD-like receptor signaling pathway	5/981	157/7206	1.5908102937e-05
ko04514	Cell adhesion molecules (CAMs)	36/981	130/7206	2.3034312112e-05
ko04360	Axon guidance	55/981	233/7206	2.50942646746e-05
ko03013	RNA transport	6/981	166/7206	2.72488983444e-05
ko04730	Long-term depression	25/981	78/7206	3.1448906716e-05
ko05322	Systemic lupus erythematosus	5/981	151/7206	3.28981939467e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	25/981	79/7206	3.58850038692e-05
ko04745	Phototransduction - fly	15/981	38/7206	6.64038338586e-05
ko04260	Cardiac muscle contraction	28/981	98/7206	8.14166077395e-05
ko04972	Pancreatic secretion	30/981	111/7206	0.000208636834222
ko04612	Antigen processing and presentation	1/981	77/7206	0.000310297393855
ko05169	Epstein-Barr virus infection	12/981	206/7206	0.000412971338504
ko04022	cGMP-PKG signaling pathway	48/981	216/7206	0.000544731972141
ko05110	Vibrio cholerae infection	19/981	63/7206	0.000581503756819
ko05166	HTLV-I infection	21/981	292/7206	0.000633853559889
ko05205	Proteoglycans in cancer	19/981	271/7206	0.000770578643449
ko04110	Cell cycle	7/981	145/7206	0.000838857233095
ko04064	NF-kappa B signaling pathway	3/981	96/7206	0.000846905298359
ko04964	Proximal tubule bicarbonate reclamation	11/981	29/7206	0.000932194692417
ko04070	Phosphatidylinositol signaling system	28/981	112/7206	0.00116752901125
ko04924	Renin secretion	23/981	86/7206	0.0012145062247
ko04141	Protein processing in endoplasmic reticulum	11/981	184/7206	0.00143237484853
ko03008	Ribosome biogenesis in eukaryotes	2/981	79/7206	0.00143885529586
ko05161	Hepatitis B	10/981	173/7206	0.00150524101719
ko04961	Endocrine and other factor-regulated calcium reabsorption	17/981	59/7206	0.0018362053565
ko04750	Inflammatory mediator regulation of TRP channels	29/981	122/7206	0.00201034999386
ko05140	Leishmaniasis	2/981	75/7206	0.00209977869486
ko04540	Gap junction	30/981	128/7206	0.00246108372428
ko04976	Bile secretion	21/981	80/7206	0.00258198084364
ko04072	Phospholipase D signaling pathway	42/981	197/7206	0.00294553882513
ko05162	Measles	6/981	120/7206	0.00298383627888
ko05414	Dilated cardiomyopathy	27/981	112/7206	0.00308853420006
ko04014	Ras signaling pathway	55/981	279/7206	0.00418500176994
ko05410	Hypertrophic cardiomyopathy (HCM)	24/981	100/7206	0.00469832174094
ko00480	Glutathione metabolism	1/981	55/7206	0.00503640873414
ko04915	Estrogen signaling pathway	29/981	131/7206	0.0065847567308
ko04626	Plant-pathogen interaction	7/981	18/7206	0.00687916671125
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/981	14/7206	0.00710206795089
ko00590	Arachidonic acid metabolism	1/981	52/7206	0.00748497738909
ko04146	Peroxisome	4/981	89/7206	0.00769685230195
ko05120	Epithelial cell signaling in Helicobacter pylori infection	22/981	92/7206	0.00828700357812
ko00561	Glycerolipid metabolism	2/981	63/7206	0.00931855387802
ko04640	Hematopoietic cell lineage	2/981	64/7206	0.00936760330919
ko04668	TNF signaling pathway	7/981	120/7206	0.0100971329406
ko01524	Platinum drug resistance	3/981	76/7206	0.0105127983713
ko00240	Pyrimidine metabolism	6/981	110/7206	0.0107731548907
ko00330	Arginine and proline metabolism	2/981	61/7206	0.0135301739823
ko04330	Notch signaling pathway	2/981	62/7206	0.0138616194764
ko04371	Apelin signaling pathway	36/981	177/7206	0.0139993381043
ko04214	Apoptosis - fly	3/981	72/7206	0.014627773288
ko00310	Lysine degradation	3/981	73/7206	0.0148838660871
ko03420	Nucleotide excision repair	1/981	46/7206	0.016452584064
ko00260	Glycine, serine and threonine metabolism	1/981	48/7206	0.0174003308056
ko04630	Jak-STAT signaling pathway	9/981	132/7206	0.0203579279977
ko03022	Basal transcription factors	1/981	44/7206	0.0247565631848
ko05144	Malaria	1/981	45/7206	0.0257085669903
ko00071	Fatty acid degradation	1/981	45/7206	0.0257085669903
ko04657	IL-17 signaling pathway	5/981	87/7206	0.0273139626535
ko00280	Valine, leucine and isoleucine degradation	2/981	54/7206	0.0277294167669
ko04140	Autophagy - animal	13/981	164/7206	0.0286197595526
ko05321	Inflammatory bowel disease (IBD)	2/981	56/7206	0.0286891958251
ko04658	Th1 and Th2 cell differentiation	6/981	96/7206	0.0346957821859
ko05145	Toxoplasmosis	9/981	126/7206	0.0348462695378
ko00980	Metabolism of xenobiotics by cytochrome P450	1/981	40/7206	0.0358957614164
ko04210	Apoptosis	15/981	180/7206	0.0360803510294
ko00140	Steroid hormone biosynthesis	1/981	41/7206	0.0365388934219
ko04932	Non-alcoholic fatty liver disease (NAFLD)	15/981	182/7206	0.0366052688037
ko03018	RNA degradation	5/981	84/7206	0.0369813013937
ko00983	Drug metabolism - other enzymes	1/981	42/7206	0.0379070839158
ko04115	p53 signaling pathway	4/981	74/7206	0.0393083544508
ko04622	RIG-I-like receptor signaling pathway	3/981	62/7206	0.0401988324394
ko05323	Rheumatoid arthritis	19/981	89/7206	0.0417338779558
ko05206	MicroRNAs in cancer	15/981	177/7206	0.0451846335358
ko04217	Necroptosis	15/981	178/7206	0.0454642743268
ko05215	Prostate cancer	8/981	111/7206	0.0498685776534