ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	163/867	423/7206	7.01887224354e-48
ko05033	Nicotine addiction	41/867	56/7206	2.28223148428e-26
ko04724	Glutamatergic synapse	67/867	152/7206	1.39504159363e-23
ko04721	Synaptic vesicle cycle	44/867	80/7206	1.26814013169e-20
ko04728	Dopaminergic synapse	68/867	185/7206	1.17756966323e-18
ko05032	Morphine addiction	49/867	110/7206	9.1780129713e-18
ko04024	cAMP signaling pathway	84/867	279/7206	1.37008558338e-16
ko04727	GABAergic synapse	46/867	110/7206	1.86222306407e-15
ko04713	Circadian entrainment	52/867	136/7206	2.37299844358e-15
ko04020	Calcium signaling pathway	78/867	265/7206	8.1755706416e-15
ko04723	Retrograde endocannabinoid signaling	58/867	175/7206	9.21525975015e-14
ko04725	Cholinergic synapse	54/867	160/7206	2.93953080552e-13
ko04726	Serotonergic synapse	46/867	137/7206	2.18000859753e-11
ko04911	Insulin secretion	41/867	117/7206	5.96750772277e-11
ko05031	Amphetamine addiction	34/867	91/7206	3.70146109416e-10
ko04921	Oxytocin signaling pathway	57/867	209/7206	1.01367775513e-09
ko04972	Pancreatic secretion	37/867	111/7206	2.59045331459e-09
ko04261	Adrenergic signaling in cardiomyocytes	54/867	205/7206	1.15047036346e-08
ko04742	Taste transduction	24/867	61/7206	4.58622490585e-08
ko04970	Salivary secretion	31/867	95/7206	8.92600456135e-08
ko05030	Cocaine addiction	26/867	73/7206	1.3706415787e-07
ko03040	Spliceosome	1/867	145/7206	2.24638293091e-07
ko04966	Collecting duct acid secretion	14/867	26/7206	2.87940742849e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	25/867	74/7206	7.57436304909e-07
ko04720	Long-term potentiation	30/867	99/7206	8.77081064784e-07
ko05164	Influenza A	3/867	167/7206	1.59219557909e-06
ko04971	Gastric acid secretion	29/867	98/7206	2.2857210643e-06
ko04514	Cell adhesion molecules (CAMs)	35/867	130/7206	3.38246370342e-06
ko04976	Bile secretion	25/867	80/7206	3.8470104207e-06
ko05110	Vibrio cholerae infection	21/867	63/7206	7.38121439914e-06
ko05203	Viral carcinogenesis	12/867	277/7206	1.16555313746e-05
ko04141	Protein processing in endoplasmic reticulum	6/867	184/7206	4.40222127759e-05
ko04925	Aldosterone synthesis and secretion	28/867	105/7206	4.97910686037e-05
ko04120	Ubiquitin mediated proteolysis	3/867	138/7206	5.06860493534e-05
ko05162	Measles	2/867	120/7206	5.087397706e-05
ko04924	Renin secretion	24/867	86/7206	6.43893572507e-05
ko04060	Cytokine-cytokine receptor interaction	7/867	191/7206	6.6315739151e-05
ko05169	Epstein-Barr virus infection	8/867	206/7206	7.28264445595e-05
ko04022	cGMP-PKG signaling pathway	46/867	216/7206	0.000107135509025
ko05168	Herpes simplex infection	7/867	182/7206	0.000182553002368
ko04010	MAPK signaling pathway	61/867	321/7206	0.000209290385039
ko05322	Systemic lupus erythematosus	5/867	151/7206	0.000213971519126
ko03013	RNA transport	6/867	166/7206	0.000239415126755
ko04621	NOD-like receptor signaling pathway	6/867	157/7206	0.000459491063158
ko04730	Long-term depression	20/867	78/7206	0.000735189172147
ko04072	Phospholipase D signaling pathway	40/867	197/7206	0.000764900139026
ko05205	Proteoglycans in cancer	16/867	271/7206	0.000817602230303
ko04140	Autophagy - animal	7/867	164/7206	0.00091938900244
ko04550	Signaling pathways regulating pluripotency of stem cells	7/867	165/7206	0.000935141743288
ko04612	Antigen processing and presentation	1/867	77/7206	0.00114823997887
ko05161	Hepatitis B	8/867	173/7206	0.00125853281297
ko04540	Gap junction	28/867	128/7206	0.00140547775916
ko04964	Proximal tubule bicarbonate reclamation	10/867	29/7206	0.00140743715118
ko02010	ABC transporters	12/867	39/7206	0.00150559943821
ko04932	Non-alcoholic fatty liver disease (NAFLD)	9/867	182/7206	0.00166628527215
ko04750	Inflammatory mediator regulation of TRP channels	27/867	122/7206	0.00168788885076
ko04961	Endocrine and other factor-regulated calcium reabsorption	16/867	59/7206	0.00172189879484
ko04110	Cell cycle	6/867	145/7206	0.00172918938572
ko04978	Mineral absorption	12/867	40/7206	0.00191986750619
ko04350	TGF-beta signaling pathway	3/867	103/7206	0.0019334073394
ko04218	Cellular senescence	9/867	177/7206	0.00222497088322
ko05166	HTLV-I infection	19/867	292/7206	0.00229983315938
ko04915	Estrogen signaling pathway	28/867	131/7206	0.00248139501111
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	19/867	79/7206	0.00256450911829
ko05120	Epithelial cell signaling in Helicobacter pylori infection	21/867	92/7206	0.00318678492268
ko04510	Focal adhesion	15/867	240/7206	0.0033345772269
ko04626	Plant-pathogen interaction	7/867	18/7206	0.00341562196984
ko04745	Phototransduction - fly	11/867	38/7206	0.003995824061
ko04260	Cardiac muscle contraction	22/867	98/7206	0.00416297919565
ko04630	Jak-STAT signaling pathway	6/867	132/7206	0.00440558890295
ko05414	Dilated cardiomyopathy	24/867	112/7206	0.00475375193016
ko03008	Ribosome biogenesis in eukaryotes	2/867	79/7206	0.00478817373432
ko04330	Notch signaling pathway	1/867	62/7206	0.0054073607536
ko05200	Pathways in cancer	41/867	492/7206	0.00780957803537
ko04740	Olfactory transduction	18/867	80/7206	0.00824977163944
ko04210	Apoptosis	11/867	180/7206	0.0104471630843
ko04974	Protein digestion and absorption	20/867	96/7206	0.0112831058623
ko05215	Prostate cancer	5/867	111/7206	0.0115347467068
ko05202	Transcriptional misregulation in cancer	12/867	188/7206	0.012362746017
ko04217	Necroptosis	11/867	178/7206	0.0136980738555
ko04137	Mitophagy - animal	3/867	82/7206	0.0155753518431
ko04064	NF-kappa B signaling pathway	4/867	96/7206	0.0163598919013
ko00604	Glycosphingolipid biosynthesis - ganglio series	5/867	14/7206	0.0196557027464
ko05323	Rheumatoid arthritis	18/867	89/7206	0.0217077554618
ko05219	Bladder cancer	1/867	48/7206	0.0255395309315
ko04068	FoxO signaling pathway	11/867	167/7206	0.0293991425492
ko04115	p53 signaling pathway	3/867	74/7206	0.0301732945129
ko00310	Lysine degradation	3/867	73/7206	0.0301887098862
ko05140	Leishmaniasis	3/867	75/7206	0.0304634275587
ko04975	Fat digestion and absorption	9/867	35/7206	0.0309043174569
ko05222	Small cell lung cancer	4/867	89/7206	0.0309339832272
ko04923	Regulation of lipolysis in adipocytes	16/867	77/7206	0.0319623132574
ko04744	Phototransduction	9/867	36/7206	0.0334252025491
ko05144	Malaria	1/867	45/7206	0.037465328516
ko03420	Nucleotide excision repair	1/867	46/7206	0.0378768248086
ko04070	Phosphatidylinositol signaling system	21/867	112/7206	0.038712742911
ko00250	Alanine, aspartate and glutamate metabolism	9/867	38/7206	0.0404936674371
ko03018	RNA degradation	4/867	84/7206	0.0411088649095
ko05220	Chronic myeloid leukemia	4/867	85/7206	0.041799218658
ko04113	Meiosis - yeast	3/867	70/7206	0.0418998802861
ko05410	Hypertrophic cardiomyopathy (HCM)	19/867	100/7206	0.0423190615065
ko04071	Sphingolipid signaling pathway	28/867	162/7206	0.0493699090478