ko pathway ratio_in_study ratio_in_pop p_value ko04380 Osteoclast differentiation 28/267 134/7206 3.60580755875e-14 ko04621 NOD-like receptor signaling pathway 30/267 157/7206 5.24132692289e-14 ko04060 Cytokine-cytokine receptor interaction 30/267 191/7206 1.07014047826e-11 ko05164 Influenza A 27/267 167/7206 6.23588369306e-11 ko04668 TNF signaling pathway 22/267 120/7206 3.35753381831e-10 ko05140 Leishmaniasis 17/267 75/7206 1.21033194949e-09 ko04217 Necroptosis 26/267 178/7206 1.41724374886e-09 ko04064 NF-kappa B signaling pathway 19/267 96/7206 1.46583353916e-09 ko05133 Pertussis 18/267 87/7206 1.89086530272e-09 ko04630 Jak-STAT signaling pathway 22/267 132/7206 2.23209509299e-09 ko04660 T cell receptor signaling pathway 21/267 124/7206 3.8932425802e-09 ko05162 Measles 20/267 120/7206 1.23400596853e-08 ko04620 Toll-like receptor signaling pathway 18/267 100/7206 1.95158239531e-08 ko05152 Tuberculosis 24/267 187/7206 8.24457734067e-08 ko05168 Herpes simplex infection 23/267 182/7206 2.07048964974e-07 ko05145 Toxoplasmosis 18/267 126/7206 7.4638172261e-07 ko04062 Chemokine signaling pathway 23/267 201/7206 1.24205560442e-06 ko05131 Shigellosis 14/267 82/7206 1.49918893883e-06 ko04622 RIG-I-like receptor signaling pathway 12/267 62/7206 2.1605185837e-06 ko04210 Apoptosis 21/267 180/7206 2.68410841825e-06 ko05323 Rheumatoid arthritis 14/267 89/7206 4.12311324289e-06 ko05161 Hepatitis B 20/267 173/7206 5.38466132281e-06 ko05132 Salmonella infection 14/267 98/7206 1.30668673113e-05 ko04623 Cytosolic DNA-sensing pathway 9/267 41/7206 1.42138886392e-05 ko05142 Chagas disease (American trypanosomiasis) 16/267 130/7206 2.19008206943e-05 ko05167 Kaposi's sarcoma-associated herpesvirus infection 20/267 191/7206 2.38712673349e-05 ko05144 Malaria 9/267 45/7206 3.15669782862e-05 ko05321 Inflammatory bowel disease (IBD) 10/267 56/7206 3.24790804563e-05 ko04670 Leukocyte transendothelial migration 17/267 151/7206 3.9194025211e-05 ko04666 Fc gamma R-mediated phagocytosis 15/267 122/7206 4.01499263493e-05 ko05160 Hepatitis C 17/267 153/7206 4.64408052018e-05 ko04650 Natural killer cell mediated cytotoxicity 13/267 97/7206 5.32301788286e-05 ko04657 IL-17 signaling pathway 12/267 87/7206 7.76536119847e-05 ko04662 B cell receptor signaling pathway 12/267 88/7206 8.69976987085e-05 ko04658 Th1 and Th2 cell differentiation 12/267 96/7206 0.000203291741816 ko05150 Staphylococcus aureus infection 7/267 36/7206 0.000293849992266 ko04672 Intestinal immune network for IgA production 7/267 37/7206 0.000351109080559 ko05134 Legionellosis 10/267 74/7206 0.000364109534186 ko04664 Fc epsilon RI signaling pathway 10/267 77/7206 0.000504252266934 ko04659 Th17 cell differentiation 12/267 106/7206 0.000515415573015 ko04933 AGE-RAGE signaling pathway in diabetic complications 13/267 135/7206 0.0014250342932 ko04080 Neuroactive ligand-receptor interaction 5/267 423/7206 0.00209809361151 ko04610 Complement and coagulation cascades 9/267 79/7206 0.00244243001666 ko04142 Lysosome 13/267 151/7206 0.00385559927391 ko04917 Prolactin signaling pathway 9/267 87/7206 0.00470892838238 ko05016 Huntington's disease 1/267 215/7206 0.00502497231898 ko05120 Epithelial cell signaling in Helicobacter pylori infection 9/267 92/7206 0.00679646131293 ko05130 Pathogenic Escherichia coli infection 8/267 77/7206 0.00736129653547 ko04612 Antigen processing and presentation 8/267 77/7206 0.00736129653547 ko04624 Toll and Imd signaling pathway 6/267 49/7206 0.00897602996515 ko05330 Allograft rejection 4/267 24/7206 0.0109050151886 ko04920 Adipocytokine signaling pathway 8/267 89/7206 0.016921865892 ko04020 Calcium signaling pathway 3/267 265/7206 0.0190639501497 ko04611 Platelet activation 12/267 163/7206 0.0196357958322 ko05320 Autoimmune thyroid disease 4/267 29/7206 0.0211022275555 ko05310 Asthma 3/267 17/7206 0.0232707412657 ko05340 Primary immunodeficiency 4/267 30/7206 0.023659572538 ko04932 Non-alcoholic fatty liver disease (NAFLD) 13/267 182/7206 0.0251603895262 ko05332 Graft-versus-host disease 3/267 18/7206 0.0271772305077 ko04215 Apoptosis - multiple species 5/267 47/7206 0.0290129731567 ko05143 African trypanosomiasis 4/267 32/7206 0.0293164797416 ko05100 Bacterial invasion of epithelial cells 8/267 99/7206 0.0299816321359 ko05146 Amoebiasis 8/267 99/7206 0.0299816321359 ko04640 Hematopoietic cell lineage 6/267 64/7206 0.0304577064498 ko04931 Insulin resistance 10/267 137/7206 0.035881840201 ko05034 Alcoholism 3/267 238/7206 0.0359399114404 ko04144 Endocytosis 20/267 342/7206 0.0390254516219 ko05012 Parkinson's disease 1/267 155/7206 0.0477901161328 ko04930 Type II diabetes mellitus 5/267 54/7206 0.0486571707975 ko04390 Hippo signaling pathway 2/267 188/7206 0.0490368934259