ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 124/852 423/7206 9.15373099277e-24 ko04724 Glutamatergic synapse 65/852 152/7206 1.91179275387e-22 ko05033 Nicotine addiction 35/852 56/7206 2.15161464532e-19 ko04721 Synaptic vesicle cycle 38/852 80/7206 1.95214108948e-15 ko04728 Dopaminergic synapse 62/852 185/7206 2.98058229136e-15 ko04727 GABAergic synapse 44/852 110/7206 2.81679135564e-14 ko05032 Morphine addiction 44/852 110/7206 2.81679135564e-14 ko04713 Circadian entrainment 49/852 136/7206 1.15565941314e-13 ko04723 Retrograde endocannabinoid signaling 52/852 175/7206 9.80676415351e-11 ko04725 Cholinergic synapse 48/852 160/7206 3.66135752224e-10 ko04911 Insulin secretion 38/852 117/7206 2.19890011012e-09 ko04024 cAMP signaling pathway 67/852 279/7206 6.60738971524e-09 ko05030 Cocaine addiction 26/852 73/7206 9.61193945838e-08 ko04514 Cell adhesion molecules (CAMs) 37/852 130/7206 2.4561954357e-07 ko03040 Spliceosome 1/852 145/7206 3.48493087484e-07 ko05014 Amyotrophic lateral sclerosis (ALS) 25/852 74/7206 5.43052234689e-07 ko04742 Taste transduction 22/852 61/7206 7.28865033886e-07 ko04360 Axon guidance 54/852 233/7206 7.70637433094e-07 ko04726 Serotonergic synapse 37/852 137/7206 7.80815910803e-07 ko04744 Phototransduction 16/852 36/7206 9.33472091377e-07 ko05031 Amphetamine addiction 28/852 91/7206 1.01167303838e-06 ko04060 Cytokine-cytokine receptor interaction 4/852 191/7206 1.09436404349e-06 ko04120 Ubiquitin mediated proteolysis 2/852 138/7206 7.33901773341e-06 ko05168 Herpes simplex infection 5/852 182/7206 1.28619442776e-05 ko04261 Adrenergic signaling in cardiomyocytes 46/852 205/7206 1.34458735853e-05 ko05164 Influenza A 4/852 167/7206 1.50026485878e-05 ko05203 Viral carcinogenesis 12/852 277/7206 1.60909406685e-05 ko04720 Long-term potentiation 26/852 99/7206 5.94123343161e-05 ko03013 RNA transport 5/852 166/7206 7.67897909121e-05 ko04010 MAPK signaling pathway 60/852 321/7206 0.000259136804038 ko04950 Maturity onset diabetes of the young 11/852 29/7206 0.00027211152261 ko04970 Salivary secretion 24/852 95/7206 0.000287438679749 ko05322 Systemic lupus erythematosus 5/852 151/7206 0.000305825619423 ko05162 Measles 3/852 120/7206 0.000479700803396 ko00604 Glycosphingolipid biosynthesis - ganglio series 7/852 14/7206 0.000510126617021 ko04730 Long-term depression 20/852 78/7206 0.000603898243508 ko04621 NOD-like receptor signaling pathway 6/852 157/7206 0.000648223782204 ko03008 Ribosome biogenesis in eukaryotes 1/852 79/7206 0.00119237440581 ko04540 Gap junction 28/852 128/7206 0.00123235334044 ko04740 Olfactory transduction 20/852 80/7206 0.00125848866853 ko04260 Cardiac muscle contraction 23/852 98/7206 0.0012645589917 ko04141 Protein processing in endoplasmic reticulum 9/852 184/7206 0.00167076601152 ko04022 cGMP-PKG signaling pathway 41/852 216/7206 0.00179784476178 ko05169 Epstein-Barr virus infection 11/852 206/7206 0.00203546549893 ko04974 Protein digestion and absorption 22/852 96/7206 0.00203969258618 ko04966 Collecting duct acid secretion 9/852 26/7206 0.0020844684087 ko04146 Peroxisome 2/852 89/7206 0.00239592643126 ko05205 Proteoglycans in cancer 17/852 271/7206 0.00279842015208 ko04921 Oxytocin signaling pathway 39/852 209/7206 0.00319029858383 ko01200 Carbon metabolism 5/852 128/7206 0.00328441211083 ko03018 RNA degradation 2/852 84/7206 0.0033482593333 ko04064 NF-kappa B signaling pathway 3/852 96/7206 0.00390916050425 ko00564 Glycerophospholipid metabolism 3/852 99/7206 0.0040908050072 ko04964 Proximal tubule bicarbonate reclamation 9/852 29/7206 0.00482188637262 ko04640 Hematopoietic cell lineage 1/852 64/7206 0.00551082590708 ko04924 Renin secretion 19/852 86/7206 0.00628399123212 ko04972 Pancreatic secretion 23/852 111/7206 0.00687744962807 ko04915 Estrogen signaling pathway 26/852 131/7206 0.00866230074472 ko05140 Leishmaniasis 2/852 75/7206 0.0103613376195 ko04014 Ras signaling pathway 47/852 279/7206 0.0105184227711 ko05224 Breast cancer 32/852 174/7206 0.0118681376423 ko04961 Endocrine and other factor-regulated calcium reabsorption 14/852 59/7206 0.0127741020646 ko04512 ECM-receptor interaction 17/852 79/7206 0.0128079984027 ko04110 Cell cycle 8/852 145/7206 0.013388166483 ko04976 Bile secretion 17/852 80/7206 0.0138040197195 ko04214 Apoptosis - fly 2/852 72/7206 0.0151024738852 ko00240 Pyrimidine metabolism 5/852 110/7206 0.0160423142626 ko00280 Valine, leucine and isoleucine degradation 1/852 54/7206 0.0177845587669 ko00520 Amino sugar and nucleotide sugar metabolism 1/852 55/7206 0.0183393252445 ko05034 Alcoholism 40/852 238/7206 0.0187549270597 ko04151 PI3K-Akt signaling pathway 61/852 390/7206 0.0192518785918 ko04611 Platelet activation 10/852 163/7206 0.0194803638528 ko04391 Hippo signaling pathway - fly 18/852 90/7206 0.0210139786501 ko04962 Vasopressin-regulated water reabsorption 13/852 58/7206 0.0217728427652 ko04138 Autophagy - yeast 3/852 81/7206 0.0224669797307 ko05418 Fluid shear stress and atherosclerosis 11/852 173/7206 0.0229025712372 ko00533 Glycosaminoglycan biosynthesis - keratan sulfate 5/852 15/7206 0.0248590860313 ko04657 IL-17 signaling pathway 4/852 87/7206 0.0299927739921 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 16/852 79/7206 0.032882719913 ko04217 Necroptosis 12/852 178/7206 0.0336503389787 ko04140 Autophagy - animal 11/852 164/7206 0.0374843442201 ko03420 Nucleotide excision repair 1/852 46/7206 0.0377156658705 ko04020 Calcium signaling pathway 42/852 265/7206 0.0418785816946 ko00310 Lysine degradation 3/852 73/7206 0.0427359467253 ko04978 Mineral absorption 9/852 40/7206 0.046833970652