ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 99/586 423/7206 1.25826032317e-23 ko05033 Nicotine addiction 32/586 56/7206 4.06657213215e-21 ko04721 Synaptic vesicle cycle 38/586 80/7206 4.69681233772e-21 ko04724 Glutamatergic synapse 52/586 152/7206 2.07867933019e-20 ko04728 Dopaminergic synapse 54/586 185/7206 1.32101798565e-17 ko04727 GABAergic synapse 40/586 110/7206 5.23975980338e-17 ko05032 Morphine addiction 38/586 110/7206 2.32059004434e-15 ko04723 Retrograde endocannabinoid signaling 47/586 175/7206 6.15826426557e-14 ko04713 Circadian entrainment 40/586 136/7206 1.93047003023e-13 ko04725 Cholinergic synapse 40/586 160/7206 5.68580683725e-11 ko04726 Serotonergic synapse 34/586 137/7206 2.01539783403e-09 ko05031 Amphetamine addiction 26/586 91/7206 6.99828045216e-09 ko04911 Insulin secretion 29/586 117/7206 3.2677687546e-08 ko04024 cAMP signaling pathway 49/586 279/7206 1.56966572737e-07 ko05030 Cocaine addiction 21/586 73/7206 1.75928813012e-07 ko04966 Collecting duct acid secretion 11/586 26/7206 2.33631345397e-06 ko05014 Amyotrophic lateral sclerosis (ALS) 19/586 74/7206 4.48076100073e-06 ko04921 Oxytocin signaling pathway 37/586 209/7206 4.54895219598e-06 ko04742 Taste transduction 16/586 61/7206 1.90062846184e-05 ko04720 Long-term potentiation 21/586 99/7206 3.47911050911e-05 ko04261 Adrenergic signaling in cardiomyocytes 34/586 205/7206 7.03088567811e-05 ko04060 Cytokine-cytokine receptor interaction 3/586 191/7206 0.000134358357454 ko05164 Influenza A 2/586 167/7206 0.000144271289684 ko04970 Salivary secretion 19/586 95/7206 0.000186235002035 ko04010 MAPK signaling pathway 45/586 321/7206 0.000232793827231 ko04964 Proximal tubule bicarbonate reclamation 9/586 29/7206 0.000332638524113 ko05110 Vibrio cholerae infection 14/586 63/7206 0.0004202986097 ko05322 Systemic lupus erythematosus 2/586 151/7206 0.000437952456898 ko05203 Viral carcinogenesis 8/586 277/7206 0.000442047953924 ko04514 Cell adhesion molecules (CAMs) 23/586 130/7206 0.000469078391431 ko03040 Spliceosome 2/586 145/7206 0.000634483923671 ko05162 Measles 1/586 120/7206 0.00100791431892 ko04730 Long-term depression 15/586 78/7206 0.0013241707929 ko05168 Herpes simplex infection 4/586 182/7206 0.00133809027053 ko05120 Epithelial cell signaling in Helicobacter pylori infection 17/586 92/7206 0.00142509277024 ko04540 Gap junction 21/586 128/7206 0.00163300400869 ko04621 NOD-like receptor signaling pathway 3/586 157/7206 0.00163961494499 ko04744 Phototransduction 9/586 36/7206 0.0018692053062 ko04961 Endocrine and other factor-regulated calcium reabsorption 12/586 59/7206 0.00240235067813 ko04510 Focal adhesion 8/586 240/7206 0.00364173304461 ko04924 Renin secretion 15/586 86/7206 0.00425267935969 ko04120 Ubiquitin mediated proteolysis 3/586 138/7206 0.00660873593974 ko04260 Cardiac muscle contraction 16/586 98/7206 0.00755043566365 ko04971 Gastric acid secretion 16/586 98/7206 0.00755043566365 ko03013 RNA transport 5/586 166/7206 0.00950621560471 ko04020 Calcium signaling pathway 33/586 265/7206 0.0116623078566 ko04972 Pancreatic secretion 17/586 111/7206 0.0124645088167 ko04932 Non-alcoholic fatty liver disease (NAFLD) 6/586 182/7206 0.0126447558905 ko04976 Bile secretion 13/586 80/7206 0.0128685199801 ko04141 Protein processing in endoplasmic reticulum 6/586 184/7206 0.0129252507736 ko05016 Huntington's disease 8/586 215/7206 0.0152031826443 ko00910 Nitrogen metabolism 5/586 19/7206 0.0155734600884 ko04960 Aldosterone-regulated sodium reabsorption 8/586 41/7206 0.0157979259311 ko05323 Rheumatoid arthritis 14/586 89/7206 0.0166056317184 ko04925 Aldosterone synthesis and secretion 16/586 105/7206 0.0171876756305 ko04014 Ras signaling pathway 34/586 279/7206 0.0181964776982 ko04145 Phagosome 22/586 162/7206 0.0185727892437 ko05169 Epstein-Barr virus infection 8/586 206/7206 0.0195552859469 ko04612 Antigen processing and presentation 1/586 77/7206 0.0196884630639 ko04360 Axon guidance 29/586 233/7206 0.0198977521105 ko03008 Ribosome biogenesis in eukaryotes 1/586 79/7206 0.020193012095 ko00604 Glycosphingolipid biosynthesis - ganglio series 4/586 14/7206 0.0224281273357 ko05205 Proteoglycans in cancer 12/586 271/7206 0.022691503764 ko04064 NF-kappa B signaling pathway 2/586 96/7206 0.0229202014638 ko00310 Lysine degradation 1/586 73/7206 0.028854028596 ko04745 Phototransduction - fly 7/586 38/7206 0.031246392772 ko04110 Cell cycle 5/586 145/7206 0.031606727892 ko01200 Carbon metabolism 4/586 128/7206 0.0329715130776 ko05166 HTLV-I infection 14/586 292/7206 0.036843837845 ko04611 Platelet activation 6/586 163/7206 0.04050423771 ko04211 Longevity regulating pathway 4/586 123/7206 0.0446781569932 ko04391 Hippo signaling pathway - fly 13/586 90/7206 0.0482671994698