ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	187/1165	423/7206	2.1998056748e-45
ko05033	Nicotine addiction	46/1165	56/7206	1.25603264721e-27
ko04724	Glutamatergic synapse	82/1165	152/7206	2.72345039635e-27
ko04727	GABAergic synapse	64/1165	110/7206	5.88179985916e-24
ko05032	Morphine addiction	64/1165	110/7206	5.88179985916e-24
ko04713	Circadian entrainment	70/1165	136/7206	7.28604425512e-22
ko04728	Dopaminergic synapse	79/1165	185/7206	3.50447637815e-18
ko04721	Synaptic vesicle cycle	47/1165	80/7206	3.84938353489e-18
ko04725	Cholinergic synapse	71/1165	160/7206	1.50520211882e-17
ko04723	Retrograde endocannabinoid signaling	75/1165	175/7206	2.01416706219e-17
ko04742	Taste transduction	38/1165	61/7206	4.15779606521e-16
ko04744	Phototransduction	27/1165	36/7206	7.04820084801e-15
ko04024	cAMP signaling pathway	97/1165	279/7206	7.5902617484e-15
ko04911	Insulin secretion	52/1165	117/7206	3.29075765864e-13
ko04726	Serotonergic synapse	57/1165	137/7206	7.27690757805e-13
ko04020	Calcium signaling pathway	87/1165	265/7206	1.02484378768e-11
ko04921	Oxytocin signaling pathway	73/1165	209/7206	2.10922971732e-11
ko04740	Olfactory transduction	38/1165	80/7206	4.58104216802e-11
ko03040	Spliceosome	1/1165	145/7206	3.15410222626e-10
ko05203	Viral carcinogenesis	12/1165	277/7206	6.4250340555e-10
ko04261	Adrenergic signaling in cardiomyocytes	68/1165	205/7206	1.03300715471e-09
ko04970	Salivary secretion	39/1165	95/7206	5.13914005581e-09
ko05164	Influenza A	4/1165	167/7206	1.27693859153e-08
ko05031	Amphetamine addiction	37/1165	91/7206	1.73498424945e-08
ko05168	Herpes simplex infection	6/1165	182/7206	5.6401104585e-08
ko04060	Cytokine-cytokine receptor interaction	7/1165	191/7206	6.94682337861e-08
ko03013	RNA transport	5/1165	166/7206	8.71881307136e-08
ko04720	Long-term potentiation	38/1165	99/7206	9.33885520804e-08
ko05322	Systemic lupus erythematosus	4/1165	151/7206	1.35336078464e-07
ko04971	Gastric acid secretion	37/1165	98/7206	1.9965296244e-07
ko04925	Aldosterone synthesis and secretion	38/1165	105/7206	5.88997230498e-07
ko04120	Ubiquitin mediated proteolysis	4/1165	138/7206	9.59190336999e-07
ko05161	Hepatitis B	8/1165	173/7206	3.12447365502e-06
ko04514	Cell adhesion molecules (CAMs)	42/1165	130/7206	5.16902963169e-06
ko05205	Proteoglycans in cancer	19/1165	271/7206	6.90910565052e-06
ko04964	Proximal tubule bicarbonate reclamation	15/1165	29/7206	1.00652497542e-05
ko04022	cGMP-PKG signaling pathway	60/1165	216/7206	1.24295893051e-05
ko05030	Cocaine addiction	27/1165	73/7206	1.4780833684e-05
ko04924	Renin secretion	30/1165	86/7206	2.01199934288e-05
ko03008	Ribosome biogenesis in eukaryotes	1/1165	79/7206	2.0534619937e-05
ko04621	NOD-like receptor signaling pathway	8/1165	157/7206	2.55200780659e-05
ko05169	Epstein-Barr virus infection	13/1165	206/7206	2.93350086113e-05
ko05166	HTLV-I infection	23/1165	292/7206	3.0581575707e-05
ko04976	Bile secretion	28/1165	80/7206	3.97119504067e-05
ko04966	Collecting duct acid secretion	13/1165	26/7206	6.32016043599e-05
ko04972	Pancreatic secretion	35/1165	111/7206	6.80443606881e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1165	79/7206	7.6610472903e-05
ko05162	Measles	5/1165	120/7206	7.84384531514e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	26/1165	74/7206	8.11974922978e-05
ko04360	Axon guidance	61/1165	233/7206	8.59781494705e-05
ko04745	Phototransduction - fly	16/1165	38/7206	0.000125973235248
ko04610	Complement and coagulation cascades	2/1165	79/7206	0.000172909642288
ko04141	Protein processing in endoplasmic reticulum	13/1165	184/7206	0.000337629536499
ko04010	MAPK signaling pathway	76/1165	321/7206	0.000343023131015
ko04070	Phosphatidylinositol signaling system	33/1165	112/7206	0.000386029240619
ko05140	Leishmaniasis	2/1165	75/7206	0.000387019304509
ko04064	NF-kappa B signaling pathway	4/1165	96/7206	0.000405218885319
ko04260	Cardiac muscle contraction	30/1165	98/7206	0.000429279890289
ko04730	Long-term depression	25/1165	78/7206	0.000494187365891
ko04540	Gap junction	36/1165	128/7206	0.000588542762096
ko04630	Jak-STAT signaling pathway	8/1165	132/7206	0.000724582830435
ko04750	Inflammatory mediator regulation of TRP channels	34/1165	122/7206	0.00108324557184
ko04974	Protein digestion and absorption	28/1165	96/7206	0.0011664771903
ko04110	Cell cycle	10/1165	145/7206	0.00128107859149
ko00520	Amino sugar and nucleotide sugar metabolism	1/1165	55/7206	0.00133583718481
ko05414	Dilated cardiomyopathy	31/1165	112/7206	0.00173552004013
ko04640	Hematopoietic cell lineage	2/1165	64/7206	0.00181690978322
ko05215	Prostate cancer	7/1165	111/7206	0.002598861878
ko04072	Phospholipase D signaling pathway	48/1165	197/7206	0.00304062710948
ko04146	Peroxisome	5/1165	89/7206	0.00360297303183
ko00240	Pyrimidine metabolism	7/1165	110/7206	0.00367414375072
ko04626	Plant-pathogen interaction	8/1165	18/7206	0.00435156102967
ko03420	Nucleotide excision repair	1/1165	46/7206	0.00445983373016
ko05219	Bladder cancer	1/1165	48/7206	0.004693608583
ko04612	Antigen processing and presentation	4/1165	77/7206	0.00489447407673
ko04658	Th1 and Th2 cell differentiation	6/1165	96/7206	0.00500295120075
ko05110	Vibrio cholerae infection	19/1165	63/7206	0.00514213198571
ko04140	Autophagy - animal	14/1165	164/7206	0.00516935474418
ko05321	Inflammatory bowel disease (IBD)	2/1165	56/7206	0.00573074427082
ko03022	Basal transcription factors	1/1165	44/7206	0.00668881620649
ko05144	Malaria	1/1165	45/7206	0.0068722509111
ko00071	Fatty acid degradation	1/1165	45/7206	0.0068722509111
ko03018	RNA degradation	5/1165	84/7206	0.00698659336748
ko05220	Chronic myeloid leukemia	5/1165	85/7206	0.00703170673194
ko04218	Cellular senescence	16/1165	177/7206	0.00705260005439
ko05206	MicroRNAs in cancer	16/1165	177/7206	0.00705260005439
ko04014	Ras signaling pathway	62/1165	279/7206	0.00771647708396
ko04668	TNF signaling pathway	9/1165	120/7206	0.00808765460561
ko00480	Glutathione metabolism	2/1165	55/7206	0.00868316930388
ko04978	Mineral absorption	13/1165	40/7206	0.00888763360051
ko04620	Toll-like receptor signaling pathway	7/1165	100/7206	0.00902849752582
ko04214	Apoptosis - fly	4/1165	72/7206	0.00968372338585
ko05131	Shigellosis	5/1165	82/7206	0.0097111365482
ko00310	Lysine degradation	4/1165	73/7206	0.00974873439709
ko05145	Toxoplasmosis	10/1165	126/7206	0.00984021135649
ko04115	p53 signaling pathway	4/1165	74/7206	0.0100104292917
ko04932	Non-alcoholic fatty liver disease (NAFLD)	17/1165	182/7206	0.0104089017702
ko05410	Hypertrophic cardiomyopathy (HCM)	26/1165	100/7206	0.0128711275426
ko05222	Small cell lung cancer	6/1165	89/7206	0.0129867195802
ko04371	Apelin signaling pathway	41/1165	177/7206	0.0130185843146
ko00330	Arginine and proline metabolism	3/1165	61/7206	0.0133487066418
ko04210	Apoptosis	17/1165	180/7206	0.0133680582954
ko04622	RIG-I-like receptor signaling pathway	3/1165	62/7206	0.0137458321643
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1165	14/7206	0.0164227545707
ko00260	Glycine, serine and threonine metabolism	2/1165	48/7206	0.0176817179706
ko04657	IL-17 signaling pathway	6/1165	87/7206	0.0179054021543
ko05133	Pertussis	6/1165	87/7206	0.0179054021543
ko04350	TGF-beta signaling pathway	8/1165	103/7206	0.0208305680016
ko05418	Fluid shear stress and atherosclerosis	17/1165	173/7206	0.0210449874654
ko04915	Estrogen signaling pathway	31/1165	131/7206	0.0226780040898
ko04217	Necroptosis	18/1165	178/7206	0.0233959237507
ko00630	Glyoxylate and dicarboxylate metabolism	1/1165	38/7206	0.0237455635903
ko03410	Base excision repair	1/1165	38/7206	0.0237455635903
ko05212	Pancreatic cancer	6/1165	83/7206	0.0237816603903
ko04550	Signaling pathways regulating pluripotency of stem cells	16/1165	165/7206	0.0239837013762
ko04923	Regulation of lipolysis in adipocytes	20/1165	77/7206	0.0277863858608
ko04961	Endocrine and other factor-regulated calcium reabsorption	16/1165	59/7206	0.0312311163636
ko04137	Mitophagy - animal	6/1165	82/7206	0.0329897497208
ko00860	Porphyrin and chlorophyll metabolism	1/1165	34/7206	0.0334213212684
ko04142	Lysosome	15/1165	151/7206	0.0336999292873
ko05200	Pathways in cancer	63/1165	492/7206	0.0362110409476
ko04330	Notch signaling pathway	4/1165	62/7206	0.0364452855344
ko00590	Arachidonic acid metabolism	3/1165	52/7206	0.0374345566392
ko01200	Carbon metabolism	12/1165	128/7206	0.0384934281388
ko00280	Valine, leucine and isoleucine degradation	3/1165	54/7206	0.0386171551281
ko04510	Focal adhesion	27/1165	240/7206	0.0397022895332
ko04933	AGE-RAGE signaling pathway in diabetic complications	13/1165	135/7206	0.043737708971
ko03015	mRNA surveillance pathway	8/1165	93/7206	0.0466609262636
ko05217	Basal cell carcinoma	5/1165	68/7206	0.0466709231694
ko05012	Parkinson's disease	16/1165	155/7206	0.0467592093862