ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 70/304 423/7206 1.37678470834e-24 ko05033 Nicotine addiction 26/304 56/7206 1.32851747564e-21 ko04724 Glutamatergic synapse 38/304 152/7206 8.12425420102e-20 ko04727 GABAergic synapse 31/304 110/7206 5.77782522042e-18 ko04723 Retrograde endocannabinoid signaling 36/304 175/7206 7.10670662008e-16 ko04728 Dopaminergic synapse 36/304 185/7206 4.51569014133e-15 ko04713 Circadian entrainment 30/304 136/7206 3.00406096219e-14 ko05032 Morphine addiction 26/304 110/7206 3.02461483595e-13 ko04726 Serotonergic synapse 27/304 137/7206 1.06448325325e-11 ko04725 Cholinergic synapse 26/304 160/7206 2.2002566753e-09 ko04024 cAMP signaling pathway 35/304 279/7206 4.589645842e-09 ko05014 Amyotrophic lateral sclerosis (ALS) 17/304 74/7206 7.04159869433e-09 ko05031 Amphetamine addiction 16/304 91/7206 1.00168940407e-06 ko04742 Taste transduction 13/304 61/7206 1.09605795418e-06 ko05030 Cocaine addiction 14/304 73/7206 1.63223458433e-06 ko04730 Long-term depression 14/304 78/7206 3.73388464126e-06 ko04721 Synaptic vesicle cycle 14/304 80/7206 5.09642233066e-06 ko04921 Oxytocin signaling pathway 23/304 209/7206 2.12813658395e-05 ko04911 Insulin secretion 16/304 117/7206 2.85954160018e-05 ko04720 Long-term potentiation 14/304 99/7206 6.22359089381e-05 ko04010 MAPK signaling pathway 29/304 321/7206 8.88153908803e-05 ko04261 Adrenergic signaling in cardiomyocytes 21/304 205/7206 0.000138512130275 ko04915 Estrogen signaling pathway 14/304 131/7206 0.00118907574574 ko04972 Pancreatic secretion 12/304 111/7206 0.00238225854345 ko05034 Alcoholism 20/304 238/7206 0.00279940638078 ko04060 Cytokine-cytokine receptor interaction 1/304 191/7206 0.00510388593748 ko04260 Cardiac muscle contraction 10/304 98/7206 0.00805164554265 ko04072 Phospholipase D signaling pathway 16/304 197/7206 0.0106884402633 ko04020 Calcium signaling pathway 20/304 265/7206 0.0114821852673 ko04514 Cell adhesion molecules (CAMs) 12/304 130/7206 0.0120535424495 ko05169 Epstein-Barr virus infection 2/304 206/7206 0.0126290811951 ko04621 NOD-like receptor signaling pathway 1/304 157/7206 0.0149656683328 ko04970 Salivary secretion 9/304 95/7206 0.0183523418 ko04976 Bile secretion 8/304 80/7206 0.0190030217136 ko05205 Proteoglycans in cancer 4/304 271/7206 0.0194215607499 ko04142 Lysosome 1/304 151/7206 0.0219659654095 ko05322 Systemic lupus erythematosus 1/304 151/7206 0.0219659654095 ko04971 Gastric acid secretion 9/304 98/7206 0.0220437395481 ko04120 Ubiquitin mediated proteolysis 1/304 138/7206 0.0311465154525 ko00512 Mucin type O-glycan biosynthesis 4/304 29/7206 0.0321004745099 ko04964 Proximal tubule bicarbonate reclamation 4/304 29/7206 0.0321004745099 ko04950 Maturity onset diabetes of the young 4/304 29/7206 0.0321004745099 ko03040 Spliceosome 1/304 145/7206 0.0328090452956 ko04110 Cell cycle 1/304 145/7206 0.0328090452956 ko04014 Ras signaling pathway 19/304 279/7206 0.0334073893693 ko04961 Endocrine and other factor-regulated calcium reabsorption 6/304 59/7206 0.0370918796128 ko05167 Kaposi's sarcoma-associated herpesvirus infection 14/304 191/7206 0.0418974894509 ko02025 Biofilm formation - Pseudomonas aeruginosa 1/304 1/7206 0.0421870663338 ko01200 Carbon metabolism 1/304 128/7206 0.0447493958439 ko05203 Viral carcinogenesis 5/304 277/7206 0.0454117993331 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 7/304 79/7206 0.0483085574084 ko04140 Autophagy - animal 2/304 164/7206 0.0487447034071