ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	198/1121	423/7206	5.42603900219e-56
ko05033	Nicotine addiction	50/1121	56/7206	1.93080507295e-34
ko04724	Glutamatergic synapse	88/1121	152/7206	1.04792663815e-33
ko05032	Morphine addiction	69/1121	110/7206	1.25105592188e-29
ko04727	GABAergic synapse	68/1121	110/7206	1.18508861251e-28
ko04713	Circadian entrainment	73/1121	136/7206	2.78187613169e-25
ko04728	Dopaminergic synapse	83/1121	185/7206	7.75448795991e-22
ko04725	Cholinergic synapse	72/1121	160/7206	3.64313815982e-19
ko04723	Retrograde endocannabinoid signaling	76/1121	175/7206	4.75933554963e-19
ko04024	cAMP signaling pathway	100/1121	279/7206	1.78365769785e-17
ko04744	Phototransduction	28/1121	36/7206	1.50388976384e-16
ko04721	Synaptic vesicle cycle	44/1121	80/7206	3.16948915695e-16
ko04742	Taste transduction	37/1121	61/7206	9.86209584693e-16
ko04911	Insulin secretion	53/1121	117/7206	1.45163790456e-14
ko04020	Calcium signaling pathway	91/1121	265/7206	1.46217504777e-14
ko04726	Serotonergic synapse	57/1121	137/7206	1.35446086964e-13
ko04921	Oxytocin signaling pathway	70/1121	209/7206	8.20279339215e-11
ko04261	Adrenergic signaling in cardiomyocytes	68/1121	205/7206	2.1789303827e-10
ko03040	Spliceosome	1/1121	145/7206	8.34119726365e-10
ko05031	Amphetamine addiction	38/1121	91/7206	1.49790821061e-09
ko05203	Viral carcinogenesis	12/1121	277/7206	3.04238758065e-09
ko04970	Salivary secretion	38/1121	95/7206	6.38765872828e-09
ko04720	Long-term potentiation	39/1121	99/7206	6.74941608609e-09
ko04740	Olfactory transduction	33/1121	80/7206	2.59677190504e-08
ko05030	Cocaine addiction	31/1121	73/7206	3.04329617101e-08
ko05014	Amyotrophic lateral sclerosis (ALS)	30/1121	74/7206	1.77487753899e-07
ko04060	Cytokine-cytokine receptor interaction	8/1121	191/7206	8.04378580952e-07
ko05322	Systemic lupus erythematosus	5/1121	151/7206	2.02591637912e-06
ko03013	RNA transport	7/1121	166/7206	6.14720669315e-06
ko04971	Gastric acid secretion	33/1121	98/7206	7.26306366523e-06
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1121	79/7206	1.18027792826e-05
ko04925	Aldosterone synthesis and secretion	34/1121	105/7206	1.53705594839e-05
ko05164	Influenza A	8/1121	167/7206	1.92191262541e-05
ko04972	Pancreatic secretion	35/1121	111/7206	2.71257419063e-05
ko04010	MAPK signaling pathway	78/1121	321/7206	2.71537782705e-05
ko04360	Axon guidance	60/1121	233/7206	4.46343945739e-05
ko04514	Cell adhesion molecules (CAMs)	38/1121	130/7206	6.93100030323e-05
ko04022	cGMP-PKG signaling pathway	56/1121	216/7206	7.79711807504e-05
ko04072	Phospholipase D signaling pathway	52/1121	197/7206	8.36885730608e-05
ko04260	Cardiac muscle contraction	30/1121	98/7206	0.000188611469304
ko04621	NOD-like receptor signaling pathway	9/1121	157/7206	0.000206622018289
ko04711	Circadian rhythm - fly	8/1121	13/7206	0.000206988672912
ko03008	Ribosome biogenesis in eukaryotes	2/1121	79/7206	0.000270315627954
ko04141	Protein processing in endoplasmic reticulum	12/1121	184/7206	0.000271052384223
ko05205	Proteoglycans in cancer	22/1121	271/7206	0.000306092654002
ko04745	Phototransduction - fly	15/1121	38/7206	0.00030896302407
ko05168	Herpes simplex infection	12/1121	182/7206	0.000372855465478
ko04612	Antigen processing and presentation	2/1121	77/7206	0.00039835191595
ko05169	Epstein-Barr virus infection	15/1121	206/7206	0.000412807773957
ko04961	Endocrine and other factor-regulated calcium reabsorption	20/1121	59/7206	0.000415345813564
ko05414	Dilated cardiomyopathy	32/1121	112/7206	0.000509793118595
ko04070	Phosphatidylinositol signaling system	32/1121	112/7206	0.000509793118595
ko05162	Measles	6/1121	120/7206	0.000513788912297
ko05140	Leishmaniasis	2/1121	75/7206	0.000594255124612
ko04730	Long-term depression	24/1121	78/7206	0.000729841536672
ko04110	Cell cycle	9/1121	145/7206	0.000738467726694
ko04932	Non-alcoholic fatty liver disease (NAFLD)	13/1121	182/7206	0.000837244106052
ko04976	Bile secretion	24/1121	80/7206	0.000938931326998
ko04610	Complement and coagulation cascades	3/1121	79/7206	0.00156870343978
ko00240	Pyrimidine metabolism	6/1121	110/7206	0.00200300199069
ko04710	Circadian rhythm	15/1121	43/7206	0.00208957133695
ko05016	Huntington's disease	18/1121	215/7206	0.00213613069229
ko00480	Glutathione metabolism	1/1121	55/7206	0.00213690203609
ko04750	Inflammatory mediator regulation of TRP channels	32/1121	122/7206	0.00223327124424
ko04064	NF-kappa B signaling pathway	5/1121	96/7206	0.00265262821721
ko04640	Hematopoietic cell lineage	2/1121	64/7206	0.00276774740248
ko04540	Gap junction	33/1121	128/7206	0.00282660252885
ko00590	Arachidonic acid metabolism	1/1121	52/7206	0.00314799528512
ko03018	RNA degradation	4/1121	84/7206	0.00358039851122
ko04350	TGF-beta signaling pathway	6/1121	103/7206	0.00373871621305
ko04966	Collecting duct acid secretion	10/1121	26/7206	0.0038951685495
ko04120	Ubiquitin mediated proteolysis	10/1121	138/7206	0.00428415719557
ko05161	Hepatitis B	14/1121	173/7206	0.00543235525231
ko05144	Malaria	1/1121	45/7206	0.00688816015134
ko00071	Fatty acid degradation	1/1121	45/7206	0.00688816015134
ko03420	Nucleotide excision repair	1/1121	46/7206	0.00690678444085
ko04915	Estrogen signaling pathway	32/1121	131/7206	0.00713512236173
ko04657	IL-17 signaling pathway	5/1121	87/7206	0.00718749005303
ko05133	Pertussis	5/1121	87/7206	0.00718749005303
ko04146	Peroxisome	5/1121	89/7206	0.00732927539567
ko04630	Jak-STAT signaling pathway	10/1121	132/7206	0.00758314160118
ko05110	Vibrio cholerae infection	18/1121	63/7206	0.00785828360097
ko05321	Inflammatory bowel disease (IBD)	2/1121	56/7206	0.0086265802288
ko04964	Proximal tubule bicarbonate reclamation	10/1121	29/7206	0.00944965772342
ko04658	Th1 and Th2 cell differentiation	6/1121	96/7206	0.00989476457765
ko05166	HTLV-I infection	30/1121	292/7206	0.0103792896032
ko03022	Basal transcription factors	1/1121	44/7206	0.010517329128
ko04014	Ras signaling pathway	59/1121	279/7206	0.0112758466262
ko00562	Inositol phosphate metabolism	23/1121	89/7206	0.0115106973058
ko04371	Apelin signaling pathway	40/1121	177/7206	0.0115532815681
ko04140	Autophagy - animal	14/1121	164/7206	0.0116730715825
ko05410	Hypertrophic cardiomyopathy (HCM)	25/1121	100/7206	0.0121043180697
ko04622	RIG-I-like receptor signaling pathway	3/1121	62/7206	0.0135950862817
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1121	14/7206	0.0136571121573
ko05131	Shigellosis	5/1121	82/7206	0.013700171078
ko04924	Renin secretion	22/1121	86/7206	0.0155685689234
ko04142	Lysosome	13/1121	151/7206	0.0165952964004
ko05418	Fluid shear stress and atherosclerosis	16/1121	173/7206	0.0191223651211
ko00330	Arginine and proline metabolism	3/1121	61/7206	0.0195066393726
ko03410	Base excision repair	1/1121	38/7206	0.0229159218215
ko05012	Parkinson's disease	14/1121	155/7206	0.0243345503585
ko00260	Glycine, serine and threonine metabolism	2/1121	48/7206	0.0262477902652
ko05219	Bladder cancer	2/1121	48/7206	0.0262477902652
ko04218	Cellular senescence	17/1121	177/7206	0.0269514441339
ko04217	Necroptosis	17/1121	178/7206	0.0271868723474
ko05215	Prostate cancer	9/1121	111/7206	0.0334300618307
ko05145	Toxoplasmosis	11/1121	126/7206	0.0341885311562
ko00230	Purine metabolism	41/1121	194/7206	0.034667587915
ko00310	Lysine degradation	5/1121	73/7206	0.0350509391546
ko04115	p53 signaling pathway	5/1121	74/7206	0.0350965656996
ko04620	Toll-like receptor signaling pathway	8/1121	100/7206	0.0362719832142
ko04071	Sphingolipid signaling pathway	35/1121	162/7206	0.0369086108088
ko04210	Apoptosis	18/1121	180/7206	0.0369678932859
ko00280	Valine, leucine and isoleucine degradation	3/1121	54/7206	0.0381005605511
ko00620	Pyruvate metabolism	2/1121	46/7206	0.0383891183683
ko04137	Mitophagy - animal	6/1121	82/7206	0.0445334122188
ko04510	Focal adhesion	26/1121	240/7206	0.0456702389179
ko04978	Mineral absorption	11/1121	40/7206	0.0470336387889
ko04214	Apoptosis - fly	5/1121	72/7206	0.0480209310852
ko01200	Carbon metabolism	12/1121	128/7206	0.0493908642644