ko pathway ratio_in_study ratio_in_pop p_value ko04724 Glutamatergic synapse 22/301 152/7206 2.77874023616e-07 ko04360 Axon guidance 24/301 233/7206 3.58967082638e-05 ko04144 Endocytosis 31/301 342/7206 3.89754330075e-05 ko00604 Glycosphingolipid biosynthesis - ganglio series 5/301 14/7206 0.00018038398392 ko04072 Phospholipase D signaling pathway 20/301 197/7206 0.00019745249702 ko04723 Retrograde endocannabinoid signaling 18/301 175/7206 0.000349866084593 ko00515 Mannose type O-glycan biosynthesis 6/301 25/7206 0.00045644836566 ko05033 Nicotine addiction 9/301 56/7206 0.000460244016416 ko04010 MAPK signaling pathway 27/301 321/7206 0.000477512022477 ko00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin 6/301 26/7206 0.000572816772572 ko05032 Morphine addiction 13/301 110/7206 0.000627413429199 ko00510 N-Glycan biosynthesis 8/301 50/7206 0.000979570196625 ko04914 Progesterone-mediated oocyte maturation 12/301 104/7206 0.00124704744947 ko04930 Type II diabetes mellitus 8/301 54/7206 0.00164266506136 ko04211 Longevity regulating pathway 13/301 123/7206 0.00178799447318 ko04727 GABAergic synapse 12/301 110/7206 0.00203026714165 ko04213 Longevity regulating pathway - multiple species 10/301 86/7206 0.00295229069769 ko05030 Cocaine addiction 9/301 73/7206 0.00317057940809 ko04725 Cholinergic synapse 15/301 160/7206 0.00372407882676 ko04020 Calcium signaling pathway 21/301 265/7206 0.00429998631975 ko04713 Circadian entrainment 13/301 136/7206 0.00433969646376 ko04070 Phosphatidylinositol signaling system 11/301 112/7206 0.00688656470781 ko00532 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 4/301 19/7206 0.00703251697024 ko00513 Various types of N-glycan biosynthesis 6/301 42/7206 0.00745135211673 ko04722 Neurotrophin signaling pathway 14/301 160/7206 0.00787658051686 ko04720 Long-term potentiation 10/301 99/7206 0.0080746426112 ko05210 Colorectal cancer 9/301 86/7206 0.00937356981299 ko04520 Adherens junction 10/301 103/7206 0.0105688123658 ko00562 Inositol phosphate metabolism 9/301 89/7206 0.0116260548183 ko04925 Aldosterone synthesis and secretion 10/301 105/7206 0.0120168070726 ko04391 Hippo signaling pathway - fly 9/301 90/7206 0.0124601156136 ko01521 EGFR tyrosine kinase inhibitor resistance 10/301 106/7206 0.0127947074863 ko04742 Taste transduction 7/301 61/7206 0.0130536955235 ko05231 Choline metabolism in cancer 12/301 134/7206 0.0131185600172 ko04728 Dopaminergic synapse 15/301 185/7206 0.0134765435999 ko05213 Endometrial cancer 7/301 62/7206 0.0142059328592 ko04923 Regulation of lipolysis in adipocytes 8/301 77/7206 0.0145477000765 ko04931 Insulin resistance 12/301 137/7206 0.0145513182292 ko04145 Phagosome 1/301 162/7206 0.0152117916377 ko04913 Ovarian steroidogenesis 7/301 63/7206 0.0154291251394 ko03013 RNA transport 1/301 166/7206 0.0158990918125 ko04666 Fc gamma R-mediated phagocytosis 11/301 122/7206 0.0180049618462 ko01522 Endocrine resistance 11/301 124/7206 0.0191011153715 ko05206 MicroRNAs in cancer 14/301 177/7206 0.0201665976245 ko04670 Leukocyte transendothelial migration 1/301 151/7206 0.0217721374001 ko04011 MAPK signaling pathway - yeast 6/301 53/7206 0.022282833115 ko04915 Estrogen signaling pathway 11/301 131/7206 0.0243126432315 ko04152 AMPK signaling pathway 13/301 161/7206 0.0247934862505 ko04071 Sphingolipid signaling pathway 13/301 162/7206 0.0253101750154 ko04060 Cytokine-cytokine receptor interaction 2/301 191/7206 0.0254735678159 ko04550 Signaling pathways regulating pluripotency of stem cells 13/301 165/7206 0.0270997633423 ko04068 FoxO signaling pathway 13/301 167/7206 0.0284948445559 ko04911 Insulin secretion 10/301 117/7206 0.0305574742591 ko04261 Adrenergic signaling in cardiomyocytes 15/301 205/7206 0.0316218863651 ko04024 cAMP signaling pathway 19/301 279/7206 0.0317710709634 ko03040 Spliceosome 1/301 145/7206 0.0322762889649 ko04912 GnRH signaling pathway 10/301 122/7206 0.0362554964135 ko04390 Hippo signaling pathway 14/301 188/7206 0.0385568508745 ko04320 Dorso-ventral axis formation 4/301 31/7206 0.0386277898555 ko04730 Long-term depression 7/301 78/7206 0.0436092931062 ko04330 Notch signaling pathway 6/301 62/7206 0.0438279181125 ko04140 Autophagy - animal 12/301 164/7206 0.0483767948113