ko pathway ratio_in_study ratio_in_pop p_value ko04922 Glucagon signaling pathway 29/585 128/7206 2.57626392387e-07 ko04713 Circadian entrainment 30/585 136/7206 2.98169978817e-07 ko04724 Glutamatergic synapse 32/585 152/7206 3.7178272306e-07 ko04710 Circadian rhythm 14/585 43/7206 3.96355878117e-06 ko04921 Oxytocin signaling pathway 37/585 209/7206 4.3917430765e-06 ko04020 Calcium signaling pathway 42/585 265/7206 2.63449243961e-05 ko04925 Aldosterone synthesis and secretion 22/585 105/7206 2.71261415115e-05 ko04745 Phototransduction - fly 12/585 38/7206 2.77196826031e-05 ko05031 Amphetamine addiction 20/585 91/7206 3.02676603231e-05 ko04911 Insulin secretion 23/585 117/7206 5.21560358257e-05 ko03040 Spliceosome 1/585 145/7206 9.05754670781e-05 ko00120 Primary bile acid biosynthesis 8/585 20/7206 9.407232392e-05 ko04720 Long-term potentiation 20/585 99/7206 0.000107157555788 ko04022 cGMP-PKG signaling pathway 34/585 216/7206 0.000185937302794 ko00010 Glycolysis / Gluconeogenesis 16/585 74/7206 0.000228255113773 ko03010 Ribosome 1/585 129/7206 0.000450664485759 ko04070 Phosphatidylinositol signaling system 20/585 112/7206 0.000670107415655 ko04726 Serotonergic synapse 23/585 137/7206 0.000708851538018 ko04966 Collecting duct acid secretion 8/585 26/7206 0.000753372876274 ko04971 Gastric acid secretion 18/585 98/7206 0.00102227159946 ko04725 Cholinergic synapse 25/585 160/7206 0.00173651161188 ko04970 Salivary secretion 17/585 95/7206 0.00177734314057 ko04626 Plant-pathogen interaction 6/585 18/7206 0.00221894315948 ko05322 Systemic lupus erythematosus 3/585 151/7206 0.00229704222224 ko04728 Dopaminergic synapse 27/585 185/7206 0.00243943828135 ko01040 Biosynthesis of unsaturated fatty acids 7/585 25/7206 0.00295223489183 ko04371 Apelin signaling pathway 26/585 177/7206 0.00298844331696 ko04110 Cell cycle 3/585 145/7206 0.00323547733765 ko01230 Biosynthesis of amino acids 15/585 85/7206 0.00387317899426 ko04727 GABAergic synapse 18/585 110/7206 0.0039656976608 ko04270 Vascular smooth muscle contraction 23/585 154/7206 0.00402912542951 ko04924 Renin secretion 15/585 86/7206 0.00420326848815 ko00140 Steroid hormone biosynthesis 9/585 41/7206 0.00477313499146 ko00680 Methane metabolism 8/585 34/7206 0.00490941446163 ko04730 Long-term depression 14/585 78/7206 0.00495241131933 ko00051 Fructose and mannose metabolism 9/585 42/7206 0.00564890436869 ko04721 Synaptic vesicle cycle 14/585 80/7206 0.00572327043621 ko05203 Viral carcinogenesis 11/585 277/7206 0.00692777897767 ko05224 Breast cancer 5/585 174/7206 0.0070210130627 ko01200 Carbon metabolism 19/585 128/7206 0.00850374124637 ko04540 Gap junction 19/585 128/7206 0.00850374124637 ko00362 Benzoate degradation 3/585 6/7206 0.00883631721997 ko00620 Pyruvate metabolism 9/585 46/7206 0.0104437687825 ko04750 Inflammatory mediator regulation of TRP channels 18/585 122/7206 0.0113522463364 ko03320 PPAR signaling pathway 12/585 69/7206 0.0116870301715 ko04068 FoxO signaling pathway 23/585 167/7206 0.0136166179248 ko04144 Endocytosis 16/585 342/7206 0.0146200522185 ko04146 Peroxisome 14/585 89/7206 0.0164907279812 ko04711 Circadian rhythm - fly 4/585 13/7206 0.0169970603383 ko05014 Amyotrophic lateral sclerosis (ALS) 12/585 74/7206 0.0170925021373 ko04919 Thyroid hormone signaling pathway 20/585 143/7206 0.0187044075333 ko00710 Carbon fixation in photosynthetic organisms 6/585 27/7206 0.0189249530201 ko04261 Adrenergic signaling in cardiomyocytes 26/585 205/7206 0.0193706101231 ko05169 Epstein-Barr virus infection 8/585 206/7206 0.0195612163006 ko05230 Central carbon metabolism in cancer 13/585 81/7206 0.0211798077754 ko04138 Autophagy - yeast 13/585 81/7206 0.0211798077754 ko04137 Mitophagy - animal 13/585 82/7206 0.0219093996323 ko04024 cAMP signaling pathway 33/585 279/7206 0.0250871025369 ko00071 Fatty acid degradation 8/585 45/7206 0.0265649089938 ko01212 Fatty acid metabolism 10/585 60/7206 0.027524810055 ko04141 Protein processing in endoplasmic reticulum 7/585 184/7206 0.0278126757303 ko04066 HIF-1 signaling pathway 17/585 123/7206 0.028545001409 ko03013 RNA transport 6/585 166/7206 0.0299341616732 ko00562 Inositol phosphate metabolism 13/585 89/7206 0.0311942765133 ko04136 Autophagy - other 6/585 31/7206 0.0357729288217 ko04650 Natural killer cell mediated cytotoxicity 14/585 97/7206 0.0361402235064 ko05200 Pathways in cancer 28/585 492/7206 0.0400479571948 ko04114 Oocyte meiosis 18/585 139/7206 0.0411944223768 ko04080 Neuroactive ligand-receptor interaction 46/585 423/7206 0.042814957209 ko04960 Aldosterone-regulated sodium reabsorption 7/585 41/7206 0.0448134911143 ko04657 IL-17 signaling pathway 2/585 87/7206 0.0458395697302 ko00052 Galactose metabolism 6/585 33/7206 0.0469524514056