ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	190/1157	423/7206	6.5352614838e-48
ko04724	Glutamatergic synapse	89/1157	152/7206	1.66192672812e-33
ko05033	Nicotine addiction	47/1157	56/7206	3.58663155055e-29
ko05032	Morphine addiction	65/1157	110/7206	5.08419350294e-25
ko04727	GABAergic synapse	64/1157	110/7206	3.96807102625e-24
ko04713	Circadian entrainment	72/1157	136/7206	1.32031854644e-23
ko04721	Synaptic vesicle cycle	50/1157	80/7206	4.92450851313e-21
ko04728	Dopaminergic synapse	82/1157	185/7206	2.90814362895e-20
ko04725	Cholinergic synapse	73/1157	160/7206	4.97038067594e-19
ko04024	cAMP signaling pathway	103/1157	279/7206	4.94763050407e-18
ko04020	Calcium signaling pathway	99/1157	265/7206	1.23220218494e-17
ko04723	Retrograde endocannabinoid signaling	74/1157	175/7206	5.5311288676e-17
ko04742	Taste transduction	37/1157	61/7206	2.82017568335e-15
ko04744	Phototransduction	27/1157	36/7206	5.90618361375e-15
ko04921	Oxytocin signaling pathway	78/1157	209/7206	3.55101161735e-14
ko04911	Insulin secretion	53/1157	117/7206	5.56304886951e-14
ko04726	Serotonergic synapse	58/1157	137/7206	1.35799051934e-13
ko04720	Long-term potentiation	44/1157	99/7206	1.76485729049e-11
ko05031	Amphetamine addiction	41/1157	91/7206	5.12349828284e-11
ko03040	Spliceosome	1/1157	145/7206	3.17998291043e-10
ko04261	Adrenergic signaling in cardiomyocytes	69/1157	205/7206	3.90694010583e-10
ko04970	Salivary secretion	39/1157	95/7206	4.20051479395e-09
ko05203	Viral carcinogenesis	14/1157	277/7206	1.40734866145e-08
ko04360	Axon guidance	70/1157	233/7206	5.26436266881e-08
ko04060	Cytokine-cytokine receptor interaction	7/1157	191/7206	6.93775799656e-08
ko05168	Herpes simplex infection	7/1157	182/7206	3.15776685953e-07
ko04740	Olfactory transduction	31/1157	80/7206	7.58664904795e-07
ko05030	Cocaine addiction	29/1157	73/7206	9.37869644975e-07
ko04022	cGMP-PKG signaling pathway	63/1157	216/7206	1.0809050247e-06
ko04925	Aldosterone synthesis and secretion	37/1157	105/7206	1.25897596111e-06
ko04971	Gastric acid secretion	35/1157	98/7206	2.07818965701e-06
ko03013	RNA transport	7/1157	166/7206	2.81677234968e-06
ko05322	Systemic lupus erythematosus	6/1157	151/7206	4.95923770629e-06
ko04120	Ubiquitin mediated proteolysis	5/1157	138/7206	5.84059082299e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1157	74/7206	6.69380935891e-06
ko04010	MAPK signaling pathway	82/1157	321/7206	7.94097281066e-06
ko04621	NOD-like receptor signaling pathway	7/1157	157/7206	8.15078468057e-06
ko05164	Influenza A	8/1157	167/7206	9.10815639207e-06
ko04966	Collecting duct acid secretion	14/1157	26/7206	1.00408082616e-05
ko04141	Protein processing in endoplasmic reticulum	10/1157	184/7206	1.47732354147e-05
ko04745	Phototransduction - fly	17/1157	38/7206	2.75363845145e-05
ko04924	Renin secretion	29/1157	86/7206	4.4436210458e-05
ko04514	Cell adhesion molecules (CAMs)	39/1157	130/7206	5.40369744983e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1157	79/7206	7.06682198584e-05
ko05169	Epstein-Barr virus infection	14/1157	206/7206	9.92815524033e-05
ko04064	NF-kappa B signaling pathway	3/1157	96/7206	0.000111665171634
ko04972	Pancreatic secretion	34/1157	111/7206	0.000116250136909
ko04070	Phosphatidylinositol signaling system	34/1157	112/7206	0.000130287270466
ko04730	Long-term depression	26/1157	78/7206	0.000140018931218
ko04110	Cell cycle	8/1157	145/7206	0.000140138549802
ko05161	Hepatitis B	11/1157	173/7206	0.000143502625131
ko04014	Ras signaling pathway	69/1157	279/7206	0.00016309447011
ko05110	Vibrio cholerae infection	22/1157	63/7206	0.000203042240993
ko04612	Antigen processing and presentation	2/1157	77/7206	0.000259065170287
ko04260	Cardiac muscle contraction	30/1157	98/7206	0.000259097606853
ko04610	Complement and coagulation cascades	2/1157	79/7206	0.000275306432288
ko03008	Ribosome biogenesis in eukaryotes	2/1157	79/7206	0.000275306432288
ko05162	Measles	6/1157	120/7206	0.000362333472384
ko05414	Dilated cardiomyopathy	33/1157	112/7206	0.000365361203082
ko05140	Leishmaniasis	2/1157	75/7206	0.000385424381587
ko00604	Glycosphingolipid biosynthesis - ganglio series	8/1157	14/7206	0.000521495169286
ko04540	Gap junction	36/1157	128/7206	0.000560344910354
ko04371	Apelin signaling pathway	46/1157	177/7206	0.000573990321373
ko05205	Proteoglycans in cancer	24/1157	271/7206	0.00068821298206
ko04146	Peroxisome	4/1157	89/7206	0.0012059362725
ko00480	Glutathione metabolism	1/1157	55/7206	0.00132812392552
ko01524	Platinum drug resistance	3/1157	76/7206	0.00152687421815
ko00590	Arachidonic acid metabolism	1/1157	52/7206	0.00198420122022
ko04072	Phospholipase D signaling pathway	48/1157	197/7206	0.00216917924587
ko04214	Apoptosis - fly	3/1157	72/7206	0.00319882988075
ko00562	Inositol phosphate metabolism	25/1157	89/7206	0.00341511651213
ko04976	Bile secretion	23/1157	80/7206	0.00342606357538
ko04668	TNF signaling pathway	8/1157	120/7206	0.00355787819567
ko04626	Plant-pathogen interaction	8/1157	18/7206	0.00416406312431
ko05145	Toxoplasmosis	9/1157	126/7206	0.00450582443436
ko04923	Regulation of lipolysis in adipocytes	22/1157	77/7206	0.00466135364115
ko04657	IL-17 signaling pathway	5/1157	87/7206	0.00505420809354
ko05166	HTLV-I infection	30/1157	292/7206	0.00548384125052
ko04630	Jak-STAT signaling pathway	10/1157	132/7206	0.00559539752355
ko05321	Inflammatory bowel disease (IBD)	2/1157	56/7206	0.00577065287396
ko04961	Endocrine and other factor-regulated calcium reabsorption	18/1157	59/7206	0.00635303932067
ko04350	TGF-beta signaling pathway	7/1157	103/7206	0.00668885388026
ko03022	Basal transcription factors	1/1157	44/7206	0.00671482329161
ko00071	Fatty acid degradation	1/1157	45/7206	0.00682533460453
ko04210	Apoptosis	16/1157	180/7206	0.00716935967882
ko03420	Nucleotide excision repair	1/1157	46/7206	0.00717885903092
ko04915	Estrogen signaling pathway	33/1157	131/7206	0.00769237765635
ko04750	Inflammatory mediator regulation of TRP channels	31/1157	122/7206	0.00839041291731
ko00240	Pyrimidine metabolism	8/1157	110/7206	0.00855952008353
ko05410	Hypertrophic cardiomyopathy (HCM)	26/1157	100/7206	0.0090242301569
ko04510	Focal adhesion	24/1157	240/7206	0.00920242957278
ko05131	Shigellosis	5/1157	82/7206	0.00973157325773
ko00310	Lysine degradation	4/1157	73/7206	0.00973714534397
ko03018	RNA degradation	5/1157	84/7206	0.0100663530361
ko00140	Steroid hormone biosynthesis	1/1157	41/7206	0.0100879240868
ko04932	Non-alcoholic fatty liver disease (NAFLD)	17/1157	182/7206	0.0103819517584
ko05418	Fluid shear stress and atherosclerosis	16/1157	173/7206	0.011625837622
ko05222	Small cell lung cancer	6/1157	89/7206	0.0129612283555
ko00330	Arginine and proline metabolism	3/1157	61/7206	0.013328993084
ko04622	RIG-I-like receptor signaling pathway	3/1157	62/7206	0.0135999329763
ko04922	Glucagon signaling pathway	31/1157	128/7206	0.0147861563936
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1157	40/7206	0.0153492385511
ko05133	Pertussis	6/1157	87/7206	0.0177620420866
ko04964	Proximal tubule bicarbonate reclamation	10/1157	29/7206	0.0179552753009
ko00380	Tryptophan metabolism	2/1157	50/7206	0.0182884823486
ko05215	Prostate cancer	9/1157	111/7206	0.0186748790642
ko00982	Drug metabolism - cytochrome P450	1/1157	37/7206	0.0226095716673
ko00533	Glycosaminoglycan biosynthesis - keratan sulfate	6/1157	15/7206	0.0229601843637
ko00630	Glyoxylate and dicarboxylate metabolism	1/1157	38/7206	0.0234880132965
ko04912	GnRH signaling pathway	29/1157	122/7206	0.0246128499436
ko04930	Type II diabetes mellitus	15/1157	54/7206	0.0248682905198
ko04115	p53 signaling pathway	5/1157	74/7206	0.0253183592119
ko04620	Toll-like receptor signaling pathway	8/1157	100/7206	0.0272202877931
ko05206	MicroRNAs in cancer	18/1157	177/7206	0.0293044394049
ko04217	Necroptosis	18/1157	178/7206	0.0294039157208
ko05016	Huntington's disease	23/1157	215/7206	0.0297374326947
ko05120	Epithelial cell signaling in Helicobacter pylori infection	23/1157	92/7206	0.030553630422
ko00640	Propanoate metabolism	1/1157	34/7206	0.0334244906409
ko00500	Starch and sucrose metabolism	1/1157	35/7206	0.0342757042192
ko04658	Th1 and Th2 cell differentiation	8/1157	96/7206	0.0356523142045
ko04330	Notch signaling pathway	4/1157	62/7206	0.0364701120815
ko04640	Hematopoietic cell lineage	4/1157	64/7206	0.0378160202184
ko00280	Valine, leucine and isoleucine degradation	3/1157	54/7206	0.038309253035
ko05144	Malaria	2/1157	45/7206	0.03842507991
ko04933	AGE-RAGE signaling pathway in diabetic complications	13/1157	135/7206	0.0433780530188
ko03320	PPAR signaling pathway	5/1157	69/7206	0.0469256292513
ko04114	Oocyte meiosis	31/1157	139/7206	0.0473169335781