ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 81/360 423/7206 9.08105325385e-28 ko05033 Nicotine addiction 25/360 56/7206 1.74034068079e-18 ko04024 cAMP signaling pathway 41/360 279/7206 2.59500719391e-10 ko04724 Glutamatergic synapse 29/360 152/7206 2.62978926526e-10 ko04728 Dopaminergic synapse 32/360 185/7206 4.24643404956e-10 ko04727 GABAergic synapse 24/360 110/7206 5.58125584649e-10 ko05032 Morphine addiction 24/360 110/7206 5.58125584649e-10 ko04723 Retrograde endocannabinoid signaling 28/360 175/7206 3.26306107725e-08 ko04721 Synaptic vesicle cycle 18/360 80/7206 5.07717430397e-08 ko05030 Cocaine addiction 17/360 73/7206 6.99580791623e-08 ko04713 Circadian entrainment 22/360 136/7206 8.36743780635e-07 ko04742 Taste transduction 13/360 61/7206 7.18544706899e-06 ko05014 Amyotrophic lateral sclerosis (ALS) 14/360 74/7206 1.3819626756e-05 ko04261 Adrenergic signaling in cardiomyocytes 25/360 205/7206 2.82517447169e-05 ko00604 Glycosphingolipid biosynthesis - ganglio series 6/360 14/7206 3.182445319e-05 ko04725 Cholinergic synapse 21/360 160/7206 4.19803997338e-05 ko04726 Serotonergic synapse 19/360 137/7206 4.53197658554e-05 ko04010 MAPK signaling pathway 33/360 321/7206 6.31101613565e-05 ko05203 Viral carcinogenesis 2/360 277/7206 0.00011287388615 ko04921 Oxytocin signaling pathway 23/360 209/7206 0.000301763177245 ko05169 Epstein-Barr virus infection 1/360 206/7206 0.000498817564886 ko05031 Amphetamine addiction 13/360 91/7206 0.000538263185565 ko04060 Cytokine-cytokine receptor interaction 1/360 191/7206 0.00107906829582 ko04260 Cardiac muscle contraction 13/360 98/7206 0.00109994907612 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 11/360 79/7206 0.00175967866081 ko04911 Insulin secretion 14/360 117/7206 0.00197792168081 ko04020 Calcium signaling pathway 25/360 265/7206 0.00215352799221 ko03013 RNA transport 1/360 166/7206 0.00333166491522 ko05164 Influenza A 1/360 167/7206 0.0033557918952 ko05414 Dilated cardiomyopathy 13/360 112/7206 0.00370403358689 ko00533 Glycosaminoglycan biosynthesis - keratan sulfate 4/360 15/7206 0.00538935057052 ko00603 Glycosphingolipid biosynthesis - globo and isoglobo series 3/360 8/7206 0.00573755083591 ko05152 Tuberculosis 2/360 187/7206 0.00616509900102 ko05322 Systemic lupus erythematosus 1/360 151/7206 0.00709730459382 ko04932 Non-alcoholic fatty liver disease (NAFLD) 2/360 182/7206 0.00880324752863 ko04510 Focal adhesion 4/360 240/7206 0.0101503131826 ko05205 Proteoglycans in cancer 5/360 271/7206 0.0101716277472 ko03040 Spliceosome 1/360 145/7206 0.0105210098909 ko05410 Hypertrophic cardiomyopathy (HCM) 11/360 100/7206 0.0165909184102 ko04140 Autophagy - animal 2/360 164/7206 0.0174957740792 ko04068 FoxO signaling pathway 2/360 167/7206 0.0177530509936 ko01200 Carbon metabolism 1/360 128/7206 0.0217541638436 ko04970 Salivary secretion 10/360 95/7206 0.0271157621434 ko04912 GnRH signaling pathway 1/360 122/7206 0.0321666451918 ko05168 Herpes simplex infection 3/360 182/7206 0.0362278725442 ko04141 Protein processing in endoplasmic reticulum 3/360 184/7206 0.0368997420466 ko00250 Alanine, aspartate and glutamate metabolism 5/360 38/7206 0.039175698531 ko05200 Pathways in cancer 15/360 492/7206 0.0409840921498 ko00240 Pyrimidine metabolism 1/360 110/7206 0.0444760452227 ko05215 Prostate cancer 1/360 111/7206 0.0447729443501 ko04120 Ubiquitin mediated proteolysis 2/360 138/7206 0.0482412126669 ko05161 Hepatitis B 3/360 173/7206 0.0493515255835 ko02025 Biofilm formation - Pseudomonas aeruginosa 1/360 1/7206 0.0499583680268