ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	211/1241	423/7206	1.06196058263e-57
ko04724	Glutamatergic synapse	96/1241	152/7206	2.15389843418e-37
ko05033	Nicotine addiction	50/1241	56/7206	3.09435196838e-32
ko04713	Circadian entrainment	84/1241	136/7206	9.23164759395e-32
ko05032	Morphine addiction	72/1241	110/7206	1.04784276269e-29
ko04727	GABAergic synapse	71/1241	110/7206	9.8461855218e-29
ko04728	Dopaminergic synapse	89/1241	185/7206	8.5100187579e-23
ko04725	Cholinergic synapse	81/1241	160/7206	1.18828280976e-22
ko04721	Synaptic vesicle cycle	51/1241	80/7206	1.37201917184e-20
ko04723	Retrograde endocannabinoid signaling	82/1241	175/7206	3.68496898538e-20
ko04020	Calcium signaling pathway	107/1241	265/7206	9.11405205543e-20
ko04024	cAMP signaling pathway	110/1241	279/7206	3.8178862725e-19
ko04911	Insulin secretion	59/1241	117/7206	1.06626145457e-16
ko04726	Serotonergic synapse	65/1241	137/7206	1.49536697715e-16
ko04921	Oxytocin signaling pathway	85/1241	209/7206	5.60747767801e-16
ko04744	Phototransduction	28/1241	36/7206	2.3012566826e-15
ko04720	Long-term potentiation	50/1241	99/7206	2.24024981054e-14
ko04742	Taste transduction	37/1241	61/7206	2.83707002297e-14
ko04970	Salivary secretion	48/1241	95/7206	7.32972766296e-14
ko04740	Olfactory transduction	42/1241	80/7206	5.06143307547e-13
ko04261	Adrenergic signaling in cardiomyocytes	78/1241	205/7206	5.8761528735e-13
ko05031	Amphetamine addiction	45/1241	91/7206	1.19865071061e-12
ko03040	Spliceosome	1/1241	145/7206	4.36317362448e-11
ko04925	Aldosterone synthesis and secretion	44/1241	105/7206	1.92047809481e-09
ko04971	Gastric acid secretion	41/1241	98/7206	7.2647969184e-09
ko04022	cGMP-PKG signaling pathway	70/1241	216/7206	3.73430872218e-08
ko05030	Cocaine addiction	32/1241	73/7206	8.77453779404e-08
ko04540	Gap junction	47/1241	128/7206	9.06432547531e-08
ko05203	Viral carcinogenesis	18/1241	277/7206	1.44881025921e-07
ko04360	Axon guidance	72/1241	233/7206	2.04167311554e-07
ko05168	Herpes simplex infection	8/1241	182/7206	2.27755953435e-07
ko04060	Cytokine-cytokine receptor interaction	9/1241	191/7206	2.63651551718e-07
ko03013	RNA transport	7/1241	166/7206	3.81613059967e-07
ko04070	Phosphatidylinositol signaling system	41/1241	112/7206	7.59879004949e-07
ko04730	Long-term depression	32/1241	78/7206	9.18744174834e-07
ko05322	Systemic lupus erythematosus	6/1241	151/7206	9.81445622623e-07
ko04010	MAPK signaling pathway	88/1241	321/7206	3.27072191673e-06
ko04745	Phototransduction - fly	19/1241	38/7206	3.43579832845e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	29/1241	74/7206	6.41057492923e-06
ko04141	Protein processing in endoplasmic reticulum	11/1241	184/7206	6.86905577861e-06
ko04750	Inflammatory mediator regulation of TRP channels	41/1241	122/7206	9.02126445638e-06
ko04110	Cell cycle	7/1241	145/7206	1.04118398484e-05
ko04972	Pancreatic secretion	38/1241	111/7206	1.12979643062e-05
ko04072	Phospholipase D signaling pathway	58/1241	197/7206	2.01170451158e-05
ko04966	Collecting duct acid secretion	14/1241	26/7206	2.31115315673e-05
ko04621	NOD-like receptor signaling pathway	9/1241	157/7206	2.44023393982e-05
ko05164	Influenza A	10/1241	167/7206	2.59261022932e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	29/1241	79/7206	3.00457926003e-05
ko04924	Renin secretion	31/1241	86/7206	3.42460693412e-05
ko05414	Dilated cardiomyopathy	37/1241	112/7206	3.93350217018e-05
ko05169	Epstein-Barr virus infection	15/1241	206/7206	4.70701220926e-05
ko04514	Cell adhesion molecules (CAMs)	41/1241	130/7206	5.2531999485e-05
ko04915	Estrogen signaling pathway	41/1241	131/7206	5.9899729807e-05
ko04014	Ras signaling pathway	74/1241	279/7206	6.72100954598e-05
ko05110	Vibrio cholerae infection	24/1241	63/7206	6.78139129453e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1241	79/7206	7.10150550053e-05
ko04612	Antigen processing and presentation	2/1241	77/7206	0.000106095217143
ko04371	Apelin signaling pathway	51/1241	177/7206	0.000108675110162
ko04961	Endocrine and other factor-regulated calcium reabsorption	22/1241	59/7206	0.000191745302574
ko04260	Cardiac muscle contraction	32/1241	98/7206	0.000205115507937
ko04976	Bile secretion	27/1241	80/7206	0.000280551310107
ko05162	Measles	7/1241	120/7206	0.000340803436403
ko04120	Ubiquitin mediated proteolysis	9/1241	138/7206	0.000354005045532
ko04912	GnRH signaling pathway	37/1241	122/7206	0.000371285202105
ko04923	Regulation of lipolysis in adipocytes	26/1241	77/7206	0.000374716135021
ko04610	Complement and coagulation cascades	3/1241	79/7206	0.000458146393776
ko04146	Peroxisome	4/1241	89/7206	0.000555280536356
ko04064	NF-kappa B signaling pathway	5/1241	96/7206	0.000897991712362
ko00240	Pyrimidine metabolism	7/1241	110/7206	0.00129181664315
ko04626	Plant-pathogen interaction	9/1241	18/7206	0.00142010073607
ko00310	Lysine degradation	3/1241	73/7206	0.00147939579056
ko03420	Nucleotide excision repair	1/1241	46/7206	0.00279787377562
ko05205	Proteoglycans in cancer	29/1241	271/7206	0.00304421983853
ko05140	Leishmaniasis	4/1241	75/7206	0.00326731316585
ko05166	HTLV-I infection	32/1241	292/7206	0.0032947429315
ko03018	RNA degradation	5/1241	84/7206	0.00340258231397
ko04932	Non-alcoholic fatty liver disease (NAFLD)	17/1241	182/7206	0.00370403234039
ko00520	Amino sugar and nucleotide sugar metabolism	2/1241	55/7206	0.00370763169622
ko00480	Glutathione metabolism	2/1241	55/7206	0.00370763169622
ko05321	Inflammatory bowel disease (IBD)	2/1241	56/7206	0.00376602574671
ko05214	Glioma	24/1241	79/7206	0.00387541163802
ko05418	Fluid shear stress and atherosclerosis	16/1241	173/7206	0.00407859631626
ko04922	Glucagon signaling pathway	35/1241	128/7206	0.00422558497377
ko03022	Basal transcription factors	1/1241	44/7206	0.00424135515092
ko00562	Inositol phosphate metabolism	26/1241	89/7206	0.00441840322177
ko05144	Malaria	1/1241	45/7206	0.0044192436304
ko00071	Fatty acid degradation	1/1241	45/7206	0.0044192436304
ko04015	Rap1 signaling pathway	66/1241	278/7206	0.00449670991325
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1241	14/7206	0.00492625137373
ko04330	Notch signaling pathway	3/1241	62/7206	0.00621352096214
ko04622	RIG-I-like receptor signaling pathway	3/1241	62/7206	0.00621352096214
ko04270	Vascular smooth muscle contraction	40/1241	154/7206	0.00660623638342
ko04916	Melanogenesis	37/1241	142/7206	0.0068794572779
ko04350	TGF-beta signaling pathway	8/1241	103/7206	0.00815573963962
ko04657	IL-17 signaling pathway	6/1241	87/7206	0.00929508593066
ko05016	Huntington's disease	23/1241	215/7206	0.00991528536006
ko04062	Chemokine signaling pathway	49/1241	201/7206	0.0101567739425
ko04115	p53 signaling pathway	5/1241	74/7206	0.0128414438533
ko04918	Thyroid hormone synthesis	24/1241	86/7206	0.0136085302729
ko05161	Hepatitis B	18/1241	173/7206	0.0142493569557
ko05231	Choline metabolism in cancer	34/1241	134/7206	0.0150315795093
ko05410	Hypertrophic cardiomyopathy (HCM)	27/1241	100/7206	0.0154121567537
ko04114	Oocyte meiosis	35/1241	139/7206	0.0166721830422
ko04214	Apoptosis - fly	5/1241	72/7206	0.0177769799979
ko04640	Hematopoietic cell lineage	4/1241	64/7206	0.0185143188073
ko04658	Th1 and Th2 cell differentiation	8/1241	96/7206	0.0197965586108
ko04960	Aldosterone-regulated sodium reabsorption	13/1241	41/7206	0.0208688267232
ko00860	Porphyrin and chlorophyll metabolism	1/1241	34/7206	0.0215370568864
ko05145	Toxoplasmosis	12/1241	126/7206	0.0228582027123
ko00512	Mucin type O-glycan biosynthesis	10/1241	29/7206	0.0230522082641
ko04964	Proximal tubule bicarbonate reclamation	10/1241	29/7206	0.0230522082641
ko04973	Carbohydrate digestion and absorption	13/1241	42/7206	0.0240549685407
ko00330	Arginine and proline metabolism	4/1241	61/7206	0.0255448647464
ko00590	Arachidonic acid metabolism	3/1241	52/7206	0.0257536497876
ko05034	Alcoholism	54/1241	238/7206	0.0286575938557
ko04142	Lysosome	16/1241	151/7206	0.0289471786028
ko01524	Platinum drug resistance	6/1241	76/7206	0.0312548289012
ko04722	Neurotrophin signaling pathway	38/1241	160/7206	0.0335966344285
ko05217	Basal cell carcinoma	5/1241	68/7206	0.0340943678662
ko04217	Necroptosis	20/1241	178/7206	0.0342131312839
ko00980	Metabolism of xenobiotics by cytochrome P450	2/1241	40/7206	0.0357518157731
ko05131	Shigellosis	7/1241	82/7206	0.038280657206
ko04710	Circadian rhythm	13/1241	43/7206	0.039342562445
ko04012	ErbB signaling pathway	27/1241	109/7206	0.0406434908766
ko04071	Sphingolipid signaling pathway	38/1241	162/7206	0.0446852821752
ko05133	Pertussis	8/1241	87/7206	0.0453509503034
ko04210	Apoptosis	21/1241	180/7206	0.0454867402132
ko04930	Type II diabetes mellitus	15/1241	54/7206	0.0462776903367
ko05222	Small cell lung cancer	8/1241	89/7206	0.0463693411944
ko04630	Jak-STAT signaling pathway	14/1241	132/7206	0.0470397511341
ko05340	Primary immunodeficiency	1/1241	30/7206	0.0488956543674