ko pathway ratio_in_study ratio_in_pop p_value ko00350 Tyrosine metabolism 11/246 33/7206 5.84902459496e-09 ko05204 Chemical carcinogenesis 12/246 48/7206 4.48186353467e-08 ko04976 Bile secretion 15/246 80/7206 5.95047342122e-08 ko00380 Tryptophan metabolism 12/246 50/7206 7.34902481188e-08 ko04974 Protein digestion and absorption 16/246 96/7206 1.20513153435e-07 ko00360 Phenylalanine metabolism 7/246 17/7206 7.20451087465e-07 ko00140 Steroid hormone biosynthesis 10/246 41/7206 7.90050471156e-07 ko00983 Drug metabolism - other enzymes 10/246 42/7206 1.00616783144e-06 ko00830 Retinol metabolism 10/246 42/7206 1.00616783144e-06 ko00643 Styrene degradation 4/246 4/7206 1.3264226508e-06 ko04975 Fat digestion and absorption 9/246 35/7206 1.76611052403e-06 ko00071 Fatty acid degradation 10/246 45/7206 1.9929930053e-06 ko00120 Primary bile acid biosynthesis 7/246 20/7206 2.62961324534e-06 ko00982 Drug metabolism - cytochrome P450 9/246 37/7206 2.93097187344e-06 ko00980 Metabolism of xenobiotics by cytochrome P450 9/246 40/7206 5.88950383813e-06 ko03320 PPAR signaling pathway 11/246 69/7206 1.8541639346e-05 ko00362 Benzoate degradation 4/246 6/7206 1.8841572509e-05 ko04614 Renin-angiotensin system 6/246 18/7206 1.95747185993e-05 ko00260 Glycine, serine and threonine metabolism 9/246 48/7206 2.84461657261e-05 ko02010 ABC transporters 8/246 39/7206 4.04361577718e-05 ko04146 Peroxisome 12/246 89/7206 4.40094752095e-05 ko05200 Pathways in cancer 3/246 492/7206 4.85909898563e-05 ko00100 Steroid biosynthesis 6/246 21/7206 5.24837276946e-05 ko00591 Linoleic acid metabolism 6/246 22/7206 7.01192941291e-05 ko04972 Pancreatic secretion 13/246 111/7206 9.50419108956e-05 ko00960 Tropane, piperidine and pyridine alkaloid biosynthesis 3/246 4/7206 0.000153291881903 ko00950 Isoquinoline alkaloid biosynthesis 4/246 10/7206 0.000236637749625 ko00565 Ether lipid metabolism 7/246 42/7206 0.000481313328803 ko00480 Glutathione metabolism 8/246 55/7206 0.00049925938102 ko05166 HTLV-I infection 1/246 292/7206 0.000756305843781 ko01200 Carbon metabolism 12/246 128/7206 0.00135551481763 ko04010 MAPK signaling pathway 2/246 321/7206 0.00149663236459 ko00630 Glyoxylate and dicarboxylate metabolism 6/246 38/7206 0.00164131349813 ko00590 Arachidonic acid metabolism 7/246 52/7206 0.00178602500572 ko04978 Mineral absorption 6/246 40/7206 0.00215577971703 ko00592 alpha-Linolenic acid metabolism 4/246 19/7206 0.00342687299378 ko04151 PI3K-Akt signaling pathway 4/246 390/7206 0.00384309200157 ko01212 Fatty acid metabolism 7/246 60/7206 0.00409270291747 ko00130 Ubiquinone and other terpenoid-quinone biosynthesis 3/246 11/7206 0.00529117402682 ko00640 Propanoate metabolism 5/246 34/7206 0.00550845944478 ko04977 Vitamin digestion and absorption 4/246 22/7206 0.00596836008261 ko00053 Ascorbate and aldarate metabolism 4/246 22/7206 0.00596836008261 ko05203 Viral carcinogenesis 2/246 277/7206 0.00627694026983 ko00250 Alanine, aspartate and glutamate metabolism 5/246 38/7206 0.00889792439453 ko00280 Valine, leucine and isoleucine degradation 6/246 54/7206 0.00975933278464 ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis 2/246 5/7206 0.0108417779202 ko00281 Geraniol degradation 2/246 5/7206 0.0108417779202 ko00040 Pentose and glucuronate interconversions 4/246 26/7206 0.0109642761858 ko05016 Huntington's disease 1/246 215/7206 0.0111197203695 ko04973 Carbohydrate digestion and absorption 5/246 42/7206 0.0135089023995 ko04964 Proximal tubule bicarbonate reclamation 4/246 29/7206 0.0160858739084 ko00330 Arginine and proline metabolism 6/246 61/7206 0.0172351267439 ko05034 Alcoholism 2/246 238/7206 0.0178046802128 ko04610 Complement and coagulation cascades 7/246 79/7206 0.0178226592537 ko00720 Carbon fixation pathways in prokaryotes 3/246 17/7206 0.018749329433 ko00564 Glycerophospholipid metabolism 8/246 99/7206 0.0194812549923 ko00620 Pyruvate metabolism 5/246 46/7206 0.0195085191399 ko00270 Cysteine and methionine metabolism 5/246 47/7206 0.0212423602957 ko04141 Protein processing in endoplasmic reticulum 1/246 184/7206 0.0219160788169 ko00910 Nitrogen metabolism 3/246 19/7206 0.0254152445291 ko01230 Biosynthesis of amino acids 7/246 85/7206 0.0255868585865 ko00860 Porphyrin and chlorophyll metabolism 4/246 34/7206 0.0275247569742 ko01210 2-Oxocarboxylic acid metabolism 3/246 20/7206 0.029164348351 ko00410 beta-Alanine metabolism 4/246 35/7206 0.0302697139188 ko00020 Citrate cycle (TCA cycle) 4/246 35/7206 0.0302697139188 ko00500 Starch and sucrose metabolism 4/246 35/7206 0.0302697139188 ko04723 Retrograde endocannabinoid signaling 1/246 175/7206 0.0319849488581 ko04217 Necroptosis 1/246 178/7206 0.0327315174095 ko00401 Novobiocin biosynthesis 1/246 1/7206 0.0341382181516 ko04080 Neuroactive ligand-receptor interaction 7/246 423/7206 0.0377496804355 ko01524 Platinum drug resistance 6/246 76/7206 0.0446802439718 ko04144 Endocytosis 5/246 342/7206 0.045236952008 ko04550 Signaling pathways regulating pluripotency of stem cells 1/246 165/7206 0.0465147146949 ko00220 Arginine biosynthesis 3/246 24/7206 0.0468887689765 ko05010 Alzheimer's disease 2/246 202/7206 0.0490643035749 ko05169 Epstein-Barr virus infection 2/246 206/7206 0.0493260362549