ko pathway ratio_in_study ratio_in_pop p_value ko05410 Hypertrophic cardiomyopathy (HCM) 33/344 100/7206 9.12235840589e-20 ko04260 Cardiac muscle contraction 32/344 98/7206 4.86240882136e-19 ko04512 ECM-receptor interaction 27/344 79/7206 8.29819197415e-17 ko05414 Dilated cardiomyopathy 31/344 112/7206 3.63406692598e-16 ko04510 Focal adhesion 41/344 240/7206 4.07270533704e-13 ko04974 Protein digestion and absorption 24/344 96/7206 9.99296263059e-12 ko01200 Carbon metabolism 26/344 128/7206 2.03974647609e-10 ko05010 Alzheimer's disease 33/344 202/7206 3.17642017497e-10 ko00020 Citrate cycle (TCA cycle) 13/344 35/7206 3.03863950968e-09 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 18/344 79/7206 2.03607604178e-08 ko04261 Adrenergic signaling in cardiomyocytes 30/344 205/7206 2.981840649e-08 ko00010 Glycolysis / Gluconeogenesis 17/344 74/7206 4.45454030449e-08 ko05012 Parkinson's disease 25/344 155/7206 6.4087378303e-08 ko00190 Oxidative phosphorylation 22/344 127/7206 1.10477968225e-07 ko05416 Viral myocarditis 13/344 55/7206 1.25139247567e-06 ko05016 Huntington's disease 26/344 215/7206 1.01329717313e-05 ko04151 PI3K-Akt signaling pathway 38/344 390/7206 2.25127141852e-05 ko00710 Carbon fixation in photosynthetic organisms 8/344 27/7206 2.48362589296e-05 ko00620 Pyruvate metabolism 10/344 46/7206 4.71533186459e-05 ko04932 Non-alcoholic fatty liver disease (NAFLD) 21/344 182/7206 0.000144507216369 ko01230 Biosynthesis of amino acids 12/344 85/7206 0.000651891720804 ko05146 Amoebiasis 13/344 99/7206 0.000795665319696 ko04062 Chemokine signaling pathway 1/344 201/7206 0.00109873316396 ko00500 Starch and sucrose metabolism 7/344 35/7206 0.00112189283666 ko04964 Proximal tubule bicarbonate reclamation 6/344 29/7206 0.00211462473449 ko00030 Pentose phosphate pathway 6/344 32/7206 0.00357548273674 ko00350 Tyrosine metabolism 6/344 33/7206 0.00419807606617 ko04810 Regulation of actin cytoskeleton 23/344 264/7206 0.00469459469409 ko04140 Autophagy - animal 1/344 164/7206 0.00485321144223 ko03013 RNA transport 1/344 166/7206 0.00489664822896 ko00680 Methane metabolism 6/344 34/7206 0.00489727065706 ko04072 Phospholipase D signaling pathway 2/344 197/7206 0.00618943942363 ko04921 Oxytocin signaling pathway 19/344 209/7206 0.0072370404659 ko04722 Neurotrophin signaling pathway 1/344 160/7206 0.00728361263046 ko05152 Tuberculosis 2/344 187/7206 0.00879170292926 ko05322 Systemic lupus erythematosus 1/344 151/7206 0.0104814048993 ko04020 Calcium signaling pathway 22/344 265/7206 0.0114537104964 ko04728 Dopaminergic synapse 2/344 185/7206 0.0128276388388 ko00280 Valine, leucine and isoleucine degradation 7/344 54/7206 0.0136162421403 ko05203 Viral carcinogenesis 5/344 277/7206 0.013836796978 ko04114 Oocyte meiosis 1/344 139/7206 0.0148155698387 ko04922 Glucagon signaling pathway 12/344 128/7206 0.0206602844608 ko03010 Ribosome 1/344 129/7206 0.0213936483267 ko04022 cGMP-PKG signaling pathway 18/344 216/7206 0.0213998523736 ko04071 Sphingolipid signaling pathway 2/344 162/7206 0.0246969552864 ko04024 cAMP signaling pathway 6/344 279/7206 0.0313721017469 ko00250 Alanine, aspartate and glutamate metabolism 5/344 38/7206 0.0331262893727 ko05167 Kaposi's sarcoma-associated herpesvirus infection 3/344 191/7206 0.0364833922555 ko04010 MAPK signaling pathway 23/344 321/7206 0.0445214043546 ko00051 Fructose and mannose metabolism 5/344 42/7206 0.048168856945 ko03040 Spliceosome 2/344 145/7206 0.0484015126145 ko04110 Cell cycle 2/344 145/7206 0.0484015126145