ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	100/591	423/7206	6.21571975254e-24
ko04724	Glutamatergic synapse	56/591	152/7206	1.48197172997e-23
ko05033	Nicotine addiction	34/591	56/7206	1.84879188391e-23
ko04728	Dopaminergic synapse	60/591	185/7206	7.30174910606e-22
ko04713	Circadian entrainment	49/591	136/7206	3.10098740702e-20
ko04721	Synaptic vesicle cycle	35/591	80/7206	6.37980008949e-18
ko05032	Morphine addiction	40/591	110/7206	7.0736256999e-17
ko04723	Retrograde endocannabinoid signaling	51/591	175/7206	1.71522271947e-16
ko04727	GABAergic synapse	39/591	110/7206	4.75786240179e-16
ko04024	cAMP signaling pathway	60/591	279/7206	1.33085589586e-12
ko05031	Amphetamine addiction	31/591	91/7206	1.79976061963e-12
ko04921	Oxytocin signaling pathway	49/591	209/7206	6.39232008442e-12
ko04725	Cholinergic synapse	40/591	160/7206	7.39848704351e-11
ko04261	Adrenergic signaling in cardiomyocytes	45/591	205/7206	4.95520029248e-10
ko04911	Insulin secretion	31/591	117/7206	2.33690568152e-09
ko04720	Long-term potentiation	28/591	99/7206	2.85490980301e-09
ko04726	Serotonergic synapse	33/591	137/7206	9.73125193302e-09
ko05030	Cocaine addiction	22/591	73/7206	4.10734831302e-08
ko05014	Amyotrophic lateral sclerosis (ALS)	22/591	74/7206	5.4034541923e-08
ko04970	Salivary secretion	25/591	95/7206	9.80805691936e-08
ko04020	Calcium signaling pathway	45/591	265/7206	1.86275755022e-06
ko04744	Phototransduction	13/591	36/7206	2.62750909822e-06
ko04925	Aldosterone synthesis and secretion	24/591	105/7206	2.83695948219e-06
ko04730	Long-term depression	20/591	78/7206	2.93457481438e-06
ko04010	MAPK signaling pathway	51/591	321/7206	3.24000900363e-06
ko04022	cGMP-PKG signaling pathway	37/591	216/7206	1.28576768265e-05
ko04966	Collecting duct acid secretion	10/591	26/7206	2.02429128077e-05
ko04060	Cytokine-cytokine receptor interaction	2/591	191/7206	2.19715636623e-05
ko05203	Viral carcinogenesis	6/591	277/7206	2.79688289945e-05
ko05322	Systemic lupus erythematosus	1/591	151/7206	6.21422505434e-05
ko03040	Spliceosome	1/591	145/7206	9.04135865436e-05
ko04971	Gastric acid secretion	20/591	98/7206	0.00010639104174
ko05110	Vibrio cholerae infection	15/591	63/7206	0.000127626483822
ko04514	Cell adhesion molecules (CAMs)	24/591	130/7206	0.000134024007399
ko05164	Influenza A	2/591	167/7206	0.000147276082458
ko04745	Phototransduction - fly	11/591	38/7206	0.000159078891881
ko04972	Pancreatic secretion	21/591	111/7206	0.000292208337338
ko04924	Renin secretion	17/591	86/7206	0.000511386201971
ko04260	Cardiac muscle contraction	18/591	98/7206	0.0011020515542
ko04742	Taste transduction	13/591	61/7206	0.00110270023894
ko04120	Ubiquitin mediated proteolysis	2/591	138/7206	0.00137575585864
ko04540	Gap junction	21/591	128/7206	0.00177303859861
ko04626	Plant-pathogen interaction	6/591	18/7206	0.00233843734934
ko05169	Epstein-Barr virus infection	6/591	206/7206	0.00277025957998
ko04740	Olfactory transduction	15/591	80/7206	0.00290332781036
ko04360	Axon guidance	32/591	233/7206	0.00334535120338
ko05120	Epithelial cell signaling in Helicobacter pylori infection	16/591	92/7206	0.00337691892626
ko04014	Ras signaling pathway	37/591	279/7206	0.00351083857646
ko00604	Glycosphingolipid biosynthesis - ganglio series	5/591	14/7206	0.00390840405669
ko05034	Alcoholism	32/591	238/7206	0.00528619824928
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	14/591	79/7206	0.00562017371458
ko05323	Rheumatoid arthritis	15/591	89/7206	0.00591266799492
ko04114	Oocyte meiosis	21/591	139/7206	0.00694584279721
ko04961	Endocrine and other factor-regulated calcium reabsorption	11/591	59/7206	0.00764263287528
ko04630	Jak-STAT signaling pathway	3/591	132/7206	0.00926786051015
ko04141	Protein processing in endoplasmic reticulum	6/591	184/7206	0.00931358956362
ko04550	Signaling pathways regulating pluripotency of stem cells	5/591	165/7206	0.00947983842497
ko03013	RNA transport	5/591	166/7206	0.00949011774108
ko04146	Peroxisome	1/591	89/7206	0.00969155170405
ko05010	Alzheimer's disease	27/591	202/7206	0.0125492546429
ko05168	Herpes simplex infection	6/591	182/7206	0.0128228993889
ko04932	Non-alcoholic fatty liver disease (NAFLD)	6/591	182/7206	0.0128228993889
ko04070	Phosphatidylinositol signaling system	17/591	112/7206	0.0133403047164
ko05166	HTLV-I infection	13/591	292/7206	0.0160110389934
ko04350	TGF-beta signaling pathway	2/591	103/7206	0.0167190008933
ko05205	Proteoglycans in cancer	12/591	271/7206	0.0175698676374
ko04071	Sphingolipid signaling pathway	22/591	162/7206	0.0191297231564
ko04145	Phagosome	22/591	162/7206	0.0191297231564
ko01524	Platinum drug resistance	1/591	76/7206	0.0196179330924
ko04612	Antigen processing and presentation	1/591	77/7206	0.0197518758378
ko04610	Complement and coagulation cascades	1/591	79/7206	0.0204483707608
ko04072	Phospholipase D signaling pathway	25/591	197/7206	0.024878486323
ko04964	Proximal tubule bicarbonate reclamation	6/591	29/7206	0.0276730607304
ko04214	Apoptosis - fly	1/591	72/7206	0.0286793192331
ko04750	Inflammatory mediator regulation of TRP channels	17/591	122/7206	0.0287401663045
ko00240	Pyrimidine metabolism	3/591	110/7206	0.0336880774141
ko05215	Prostate cancer	3/591	111/7206	0.0340855316397
ko04915	Estrogen signaling pathway	18/591	131/7206	0.0343776792229
ko04621	NOD-like receptor signaling pathway	6/591	157/7206	0.0393280202262
ko04510	Focal adhesion	11/591	240/7206	0.0408164992245
ko04978	Mineral absorption	7/591	40/7206	0.0417581328414
ko04211	Longevity regulating pathway	4/591	123/7206	0.0448824401236
ko05220	Chronic myeloid leukemia	2/591	85/7206	0.0454147434902
ko05161	Hepatitis B	7/591	173/7206	0.0479622294948