ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	197/1146	423/7206	1.39139566344e-53
ko04724	Glutamatergic synapse	88/1146	152/7206	6.08281489774e-33
ko05033	Nicotine addiction	46/1146	56/7206	5.98720981391e-28
ko04713	Circadian entrainment	75/1146	136/7206	2.53100321828e-26
ko05032	Morphine addiction	65/1146	110/7206	2.90859158648e-25
ko04727	GABAergic synapse	63/1146	110/7206	1.7468364193e-23
ko04721	Synaptic vesicle cycle	51/1146	80/7206	3.38657920849e-22
ko04725	Cholinergic synapse	75/1146	160/7206	1.21211889673e-20
ko04728	Dopaminergic synapse	82/1146	185/7206	1.55357675192e-20
ko04024	cAMP signaling pathway	105/1146	279/7206	2.17623871165e-19
ko04020	Calcium signaling pathway	101/1146	265/7206	5.93755433399e-19
ko04723	Retrograde endocannabinoid signaling	76/1146	175/7206	1.80223208649e-18
ko04911	Insulin secretion	56/1146	117/7206	3.27904669655e-16
ko04921	Oxytocin signaling pathway	81/1146	209/7206	5.68808283374e-16
ko04742	Taste transduction	37/1146	61/7206	2.0541689392e-15
ko04970	Salivary secretion	45/1146	95/7206	4.53579613426e-13
ko04261	Adrenergic signaling in cardiomyocytes	74/1146	205/7206	8.39086267911e-13
ko04726	Serotonergic synapse	56/1146	137/7206	1.38900069197e-12
ko05031	Amphetamine addiction	40/1146	91/7206	1.6613007821e-10
ko04720	Long-term potentiation	42/1146	99/7206	2.27920545966e-10
ko03040	Spliceosome	1/1146	145/7206	5.17411595903e-10
ko05203	Viral carcinogenesis	12/1146	277/7206	1.40004360607e-09
ko04925	Aldosterone synthesis and secretion	42/1146	105/7206	2.02722566958e-09
ko04022	cGMP-PKG signaling pathway	69/1146	216/7206	2.31245102441e-09
ko04971	Gastric acid secretion	40/1146	98/7206	2.43887797664e-09
ko04744	Phototransduction	21/1146	36/7206	7.19575136193e-09
ko04740	Olfactory transduction	34/1146	80/7206	1.13590071075e-08
ko05168	Herpes simplex infection	5/1146	182/7206	1.29867112722e-08
ko04360	Axon guidance	69/1146	233/7206	8.13331817408e-08
ko04924	Renin secretion	34/1146	86/7206	9.87744266826e-08
ko04060	Cytokine-cytokine receptor interaction	7/1146	191/7206	1.03764327811e-07
ko05164	Influenza A	6/1146	167/7206	5.39392359073e-07
ko04976	Bile secretion	31/1146	80/7206	6.11828462944e-07
ko05030	Cocaine addiction	29/1146	73/7206	7.64495443541e-07
ko04966	Collecting duct acid secretion	15/1146	26/7206	1.30930046225e-06
ko04120	Ubiquitin mediated proteolysis	4/1146	138/7206	1.47824983442e-06
ko03013	RNA transport	7/1146	166/7206	2.83066848054e-06
ko04540	Gap junction	41/1146	128/7206	4.2259204237e-06
ko05322	Systemic lupus erythematosus	6/1146	151/7206	4.98925600938e-06
ko04964	Proximal tubule bicarbonate reclamation	15/1146	29/7206	8.17620919453e-06
ko05169	Epstein-Barr virus infection	12/1146	206/7206	1.12158486978e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	27/1146	74/7206	1.46719116747e-05
ko04972	Pancreatic secretion	36/1146	111/7206	1.74479146946e-05
ko04260	Cardiac muscle contraction	32/1146	98/7206	3.49051903837e-05
ko05414	Dilated cardiomyopathy	35/1146	112/7206	3.99111450642e-05
ko04010	MAPK signaling pathway	79/1146	321/7206	4.30681352433e-05
ko04514	Cell adhesion molecules (CAMs)	39/1146	130/7206	4.7559940198e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1146	79/7206	6.39853953693e-05
ko05110	Vibrio cholerae infection	23/1146	63/7206	6.98722167392e-05
ko05162	Measles	5/1146	120/7206	7.81953133144e-05
ko05161	Hepatitis B	10/1146	173/7206	7.96778920833e-05
ko04961	Endocrine and other factor-regulated calcium reabsorption	22/1146	59/7206	8.72992470412e-05
ko04745	Phototransduction - fly	16/1146	38/7206	0.000102976440455
ko04923	Regulation of lipolysis in adipocytes	26/1146	77/7206	0.000105078544611
ko04750	Inflammatory mediator regulation of TRP channels	36/1146	122/7206	0.000138913860862
ko04141	Protein processing in endoplasmic reticulum	12/1146	184/7206	0.00014227460519
ko04621	NOD-like receptor signaling pathway	9/1146	157/7206	0.000146501321013
ko05205	Proteoglycans in cancer	22/1146	271/7206	0.000176257046265
ko04110	Cell cycle	8/1146	145/7206	0.000200147810437
ko04610	Complement and coagulation cascades	2/1146	79/7206	0.000268017576886
ko03008	Ribosome biogenesis in eukaryotes	2/1146	79/7206	0.000268017576886
ko04070	Phosphatidylinositol signaling system	33/1146	112/7206	0.000345494232903
ko05140	Leishmaniasis	2/1146	75/7206	0.000388787919354
ko04612	Antigen processing and presentation	2/1146	77/7206	0.000408952366797
ko04730	Long-term depression	25/1146	78/7206	0.000440385424082
ko04371	Apelin signaling pathway	46/1146	177/7206	0.000524341659597
ko04064	NF-kappa B signaling pathway	4/1146	96/7206	0.000603626101725
ko04626	Plant-pathogen interaction	9/1146	18/7206	0.000782606233192
ko04072	Phospholipase D signaling pathway	49/1146	197/7206	0.0010208149425
ko04630	Jak-STAT signaling pathway	8/1146	132/7206	0.00102857674034
ko04014	Ras signaling pathway	65/1146	279/7206	0.00106365491639
ko04146	Peroxisome	4/1146	89/7206	0.00121904994268
ko00480	Glutathione metabolism	1/1146	55/7206	0.00132915641977
ko00240	Pyrimidine metabolism	6/1146	110/7206	0.00139738471181
ko04915	Estrogen signaling pathway	35/1146	131/7206	0.0015178311182
ko00590	Arachidonic acid metabolism	1/1146	52/7206	0.00200129208865
ko04640	Hematopoietic cell lineage	2/1146	64/7206	0.00284702587989
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1146	14/7206	0.00309034177884
ko04214	Apoptosis - fly	3/1146	72/7206	0.00319835788565
ko00310	Lysine degradation	3/1146	73/7206	0.00324984266379
ko04978	Mineral absorption	14/1146	40/7206	0.00337066095235
ko00330	Arginine and proline metabolism	2/1146	61/7206	0.00409482057185
ko05219	Bladder cancer	1/1146	48/7206	0.00458381351842
ko04270	Vascular smooth muscle contraction	38/1146	154/7206	0.00499903616648
ko05410	Hypertrophic cardiomyopathy (HCM)	27/1146	100/7206	0.00529259985762
ko03022	Basal transcription factors	1/1146	44/7206	0.00678461625941
ko00071	Fatty acid degradation	1/1146	45/7206	0.00679711366281
ko05166	HTLV-I infection	30/1146	292/7206	0.00681704433556
ko03420	Nucleotide excision repair	1/1146	46/7206	0.0070448556415
ko05220	Chronic myeloid leukemia	5/1146	85/7206	0.0070856070106
ko05215	Prostate cancer	8/1146	111/7206	0.00861419388802
ko05321	Inflammatory bowel disease (IBD)	2/1146	56/7206	0.00882191773083
ko03018	RNA degradation	5/1146	84/7206	0.0099130634325
ko04974	Protein digestion and absorption	25/1146	96/7206	0.0106169349091
ko04912	GnRH signaling pathway	30/1146	122/7206	0.0119832661792
ko05145	Toxoplasmosis	10/1146	126/7206	0.0132604368902
ko04932	Non-alcoholic fatty liver disease (NAFLD)	17/1146	182/7206	0.0133334352975
ko04330	Notch signaling pathway	3/1146	62/7206	0.0134855234836
ko04622	RIG-I-like receptor signaling pathway	3/1146	62/7206	0.0134855234836
ko05131	Shigellosis	5/1146	82/7206	0.013931913227
ko04658	Th1 and Th2 cell differentiation	7/1146	96/7206	0.0166149505248
ko04210	Apoptosis	17/1146	180/7206	0.0170390874333
ko04657	IL-17 signaling pathway	6/1146	87/7206	0.0177129953543
ko05133	Pertussis	6/1146	87/7206	0.0177129953543
ko00380	Tryptophan metabolism	2/1146	50/7206	0.0181096655161
ko04916	Melanogenesis	33/1146	142/7206	0.020075233448
ko04350	TGF-beta signaling pathway	8/1146	103/7206	0.0205322911951
ko04668	TNF signaling pathway	10/1146	120/7206	0.0225899338781
ko03410	Base excision repair	1/1146	38/7206	0.0232114346488
ko04933	AGE-RAGE signaling pathway in diabetic complications	12/1146	135/7206	0.0234454259742
ko04930	Type II diabetes mellitus	15/1146	54/7206	0.0237063775083
ko04114	Oocyte meiosis	32/1146	139/7206	0.0256035094541
ko01524	Platinum drug resistance	5/1146	76/7206	0.0258212599255
ko00260	Glycine, serine and threonine metabolism	2/1146	48/7206	0.0267368557666
ko04922	Glucagon signaling pathway	30/1146	128/7206	0.0271600798485
ko04620	Toll-like receptor signaling pathway	8/1146	100/7206	0.027170962937
ko04140	Autophagy - animal	16/1146	164/7206	0.0301656940953
ko04137	Mitophagy - animal	6/1146	82/7206	0.032416968899
ko05212	Pancreatic cancer	6/1146	83/7206	0.032956914106
ko00640	Propanoate metabolism	1/1146	34/7206	0.0335162185973
ko00500	Starch and sucrose metabolism	1/1146	35/7206	0.0340410472689
ko04115	p53 signaling pathway	5/1146	74/7206	0.0358127766622
ko04015	Rap1 signaling pathway	57/1146	278/7206	0.036383781727
ko00561	Glycerolipid metabolism	4/1146	63/7206	0.0367169784288
ko00600	Sphingolipid metabolism	4/1146	63/7206	0.0367169784288
ko04218	Cellular senescence	18/1146	177/7206	0.0367836873028
ko05206	MicroRNAs in cancer	18/1146	177/7206	0.0367836873028
ko04918	Thyroid hormone synthesis	21/1146	86/7206	0.0370221685756
ko04217	Necroptosis	18/1146	178/7206	0.0371451544246
ko05144	Malaria	2/1146	45/7206	0.0380076625925
ko00280	Valine, leucine and isoleucine degradation	3/1146	54/7206	0.0380408407573
ko05222	Small cell lung cancer	7/1146	89/7206	0.0398394432232
ko05120	Epithelial cell signaling in Helicobacter pylori infection	22/1146	92/7206	0.0434246791892
ko05418	Fluid shear stress and atherosclerosis	18/1146	173/7206	0.0453872739528