ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	202/1148	423/7206	3.72731742929e-57
ko04724	Glutamatergic synapse	86/1148	152/7206	4.00865368257e-31
ko05033	Nicotine addiction	48/1148	56/7206	8.48669776842e-31
ko04713	Circadian entrainment	74/1148	136/7206	1.92848340842e-25
ko04727	GABAergic synapse	64/1148	110/7206	2.53840988118e-24
ko05032	Morphine addiction	64/1148	110/7206	2.53840988118e-24
ko04721	Synaptic vesicle cycle	51/1148	80/7206	3.67440199036e-22
ko04728	Dopaminergic synapse	83/1148	185/7206	3.84525883051e-21
ko04725	Cholinergic synapse	72/1148	160/7206	1.45310843542e-18
ko04723	Retrograde endocannabinoid signaling	75/1148	175/7206	8.50838385243e-18
ko04024	cAMP signaling pathway	102/1148	279/7206	9.00096687443e-18
ko04742	Taste transduction	38/1148	61/7206	2.50887981296e-16
ko04020	Calcium signaling pathway	96/1148	265/7206	2.73553607411e-16
ko04744	Phototransduction	28/1148	36/7206	2.85316070953e-16
ko04911	Insulin secretion	53/1148	117/7206	3.99742192597e-14
ko04921	Oxytocin signaling pathway	77/1148	209/7206	7.32869131301e-14
ko04726	Serotonergic synapse	57/1148	137/7206	3.84227534042e-13
ko05203	Viral carcinogenesis	9/1148	277/7206	1.25766875941e-11
ko04970	Salivary secretion	42/1148	95/7206	4.86785244902e-11
ko04720	Long-term potentiation	43/1148	99/7206	5.81568334089e-11
ko04261	Adrenergic signaling in cardiomyocytes	70/1148	205/7206	8.34796149886e-11
ko04740	Olfactory transduction	37/1148	80/7206	1.41023663913e-10
ko05031	Amphetamine addiction	40/1148	91/7206	1.75465733796e-10
ko03040	Spliceosome	1/1148	145/7206	5.22000109765e-10
ko05168	Herpes simplex infection	6/1148	182/7206	8.55222407397e-08
ko04971	Gastric acid secretion	37/1148	98/7206	1.53113186109e-07
ko04925	Aldosterone synthesis and secretion	38/1148	105/7206	2.95639262083e-07
ko05164	Influenza A	6/1148	167/7206	5.36723888414e-07
ko04060	Cytokine-cytokine receptor interaction	8/1148	191/7206	5.59188874094e-07
ko04022	cGMP-PKG signaling pathway	63/1148	216/7206	6.25906901189e-07
ko05030	Cocaine addiction	29/1148	73/7206	7.93607991578e-07
ko04966	Collecting duct acid secretion	15/1148	26/7206	1.33973391689e-06
ko05322	Systemic lupus erythematosus	5/1148	151/7206	1.37289844614e-06
ko04514	Cell adhesion molecules (CAMs)	42/1148	130/7206	2.67345645684e-06
ko03013	RNA transport	7/1148	166/7206	2.81479053309e-06
ko05169	Epstein-Barr virus infection	11/1148	206/7206	4.10884352608e-06
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	29/1148	79/7206	6.26739235998e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1148	74/7206	6.30259190591e-06
ko04120	Ubiquitin mediated proteolysis	5/1148	138/7206	9.03614461704e-06
ko04621	NOD-like receptor signaling pathway	7/1148	157/7206	1.21029243713e-05
ko04360	Axon guidance	62/1148	233/7206	2.34577482469e-05
ko04745	Phototransduction - fly	17/1148	38/7206	2.4794194147e-05
ko04260	Cardiac muscle contraction	32/1148	98/7206	3.57051702027e-05
ko04924	Renin secretion	29/1148	86/7206	3.95232666242e-05
ko05161	Hepatitis B	10/1148	173/7206	5.54482521027e-05
ko04141	Protein processing in endoplasmic reticulum	11/1148	184/7206	5.64341412077e-05
ko04730	Long-term depression	27/1148	78/7206	5.70401705268e-05
ko05205	Proteoglycans in cancer	21/1148	271/7206	6.35824171273e-05
ko04010	MAPK signaling pathway	78/1148	321/7206	6.46687465857e-05
ko04972	Pancreatic secretion	34/1148	111/7206	0.000108385026981
ko05166	HTLV-I infection	24/1148	292/7206	0.00011225329332
ko05110	Vibrio cholerae infection	22/1148	63/7206	0.000183918682567
ko04110	Cell cycle	8/1148	145/7206	0.000200958075239
ko04540	Gap junction	37/1148	128/7206	0.000202540598427
ko04964	Proximal tubule bicarbonate reclamation	13/1148	29/7206	0.000220070968579
ko04610	Complement and coagulation cascades	2/1148	79/7206	0.000268956335388
ko03008	Ribosome biogenesis in eukaryotes	2/1148	79/7206	0.000268956335388
ko04976	Bile secretion	26/1148	80/7206	0.00028580896802
ko05414	Dilated cardiomyopathy	33/1148	112/7206	0.000348392553941
ko05162	Measles	6/1148	120/7206	0.000356305202646
ko05140	Leishmaniasis	2/1148	75/7206	0.000387701555088
ko04612	Antigen processing and presentation	2/1148	77/7206	0.000411398739418
ko04064	NF-kappa B signaling pathway	4/1148	96/7206	0.000605649567257
ko04070	Phosphatidylinositol signaling system	32/1148	112/7206	0.000613208803179
ko04750	Inflammatory mediator regulation of TRP channels	34/1148	122/7206	0.000672132112114
ko04626	Plant-pathogen interaction	9/1148	18/7206	0.000792978835536
ko04146	Peroxisome	4/1148	89/7206	0.00121514751795
ko00520	Amino sugar and nucleotide sugar metabolism	1/1148	55/7206	0.00132797333719
ko00480	Glutathione metabolism	1/1148	55/7206	0.00132797333719
ko04961	Endocrine and other factor-regulated calcium reabsorption	19/1148	59/7206	0.00183365707404
ko00590	Arachidonic acid metabolism	1/1148	52/7206	0.00199688639907
ko04630	Jak-STAT signaling pathway	9/1148	132/7206	0.00247680567135
ko04330	Notch signaling pathway	2/1148	62/7206	0.00270340358648
ko04932	Non-alcoholic fatty liver disease (NAFLD)	15/1148	182/7206	0.00279630069123
ko04640	Hematopoietic cell lineage	2/1148	64/7206	0.00286016500575
ko04214	Apoptosis - fly	3/1148	72/7206	0.00319568564407
ko00310	Lysine degradation	3/1148	73/7206	0.00325736545269
ko04072	Phospholipase D signaling pathway	47/1148	197/7206	0.00396227931199
ko04014	Ras signaling pathway	62/1148	279/7206	0.0045146123399
ko05410	Hypertrophic cardiomyopathy (HCM)	27/1148	100/7206	0.00532177655031
ko05418	Fluid shear stress and atherosclerosis	15/1148	173/7206	0.00613594988808
ko03022	Basal transcription factors	1/1148	44/7206	0.00676899450754
ko05144	Malaria	1/1148	45/7206	0.00679913090904
ko00071	Fatty acid degradation	1/1148	45/7206	0.00679913090904
ko03420	Nucleotide excision repair	1/1148	46/7206	0.00706585914166
ko04657	IL-17 signaling pathway	5/1148	87/7206	0.00722513134107
ko04668	TNF signaling pathway	9/1148	120/7206	0.00803878123654
ko05215	Prostate cancer	8/1148	111/7206	0.00860631294646
ko05321	Inflammatory bowel disease (IBD)	2/1148	56/7206	0.00885209123843
ko04350	TGF-beta signaling pathway	7/1148	103/7206	0.00927567649577
ko03018	RNA degradation	5/1148	84/7206	0.00993286607451
ko04915	Estrogen signaling pathway	32/1148	131/7206	0.0109055767362
ko04923	Regulation of lipolysis in adipocytes	21/1148	77/7206	0.0111602156882
ko00240	Pyrimidine metabolism	8/1148	110/7206	0.0118228532791
ko04933	AGE-RAGE signaling pathway in diabetic complications	11/1148	135/7206	0.0120397977396
ko04371	Apelin signaling pathway	41/1148	177/7206	0.0120768633673
ko05145	Toxoplasmosis	10/1148	126/7206	0.0133080832779
ko00330	Arginine and proline metabolism	3/1148	61/7206	0.0133672772969
ko04622	RIG-I-like receptor signaling pathway	3/1148	62/7206	0.0134989211755
ko00290	Valine, leucine and isoleucine biosynthesis	3/1148	4/7206	0.0142139518985
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1148	14/7206	0.0153099082059
ko04658	Th1 and Th2 cell differentiation	7/1148	96/7206	0.0165984578707
ko04140	Autophagy - animal	15/1148	164/7206	0.0169523754922
ko05206	MicroRNAs in cancer	17/1148	177/7206	0.0215090000998
ko00630	Glyoxylate and dicarboxylate metabolism	1/1148	38/7206	0.0232550520093
ko04550	Signaling pathways regulating pluripotency of stem cells	16/1148	165/7206	0.0238729193089
ko05220	Chronic myeloid leukemia	6/1148	85/7206	0.0241678224488
ko04115	p53 signaling pathway	5/1148	74/7206	0.0254537292108
ko01524	Platinum drug resistance	5/1148	76/7206	0.0258721648693
ko05202	Transcriptional misregulation in cancer	19/1148	188/7206	0.0260106365188
ko04978	Mineral absorption	12/1148	40/7206	0.0267214996471
ko05219	Bladder cancer	2/1148	48/7206	0.0268040363562
ko04620	Toll-like receptor signaling pathway	8/1148	100/7206	0.0271600249892
ko04922	Glucagon signaling pathway	30/1148	128/7206	0.0272980407203
ko04217	Necroptosis	18/1148	178/7206	0.0294177981167
ko04210	Apoptosis	18/1148	180/7206	0.0296545467853
ko05131	Shigellosis	6/1148	82/7206	0.0324425098964
ko00860	Porphyrin and chlorophyll metabolism	1/1148	34/7206	0.0334920002845
ko04975	Fat digestion and absorption	1/1148	35/7206	0.0340757579843
ko04974	Protein digestion and absorption	23/1148	96/7206	0.0352412663698
ko05016	Huntington's disease	23/1148	215/7206	0.0367865328254
ko00280	Valine, leucine and isoleucine degradation	3/1148	54/7206	0.0380762837737
ko05133	Pertussis	7/1148	87/7206	0.0395177799274
ko05222	Small cell lung cancer	7/1148	89/7206	0.0398997690824
ko04142	Lysosome	15/1148	151/7206	0.0426557251984
ko05120	Epithelial cell signaling in Helicobacter pylori infection	22/1148	92/7206	0.0436936656054
ko04270	Vascular smooth muscle contraction	34/1148	154/7206	0.0442580092994
ko04912	GnRH signaling pathway	28/1148	122/7206	0.0446439905429