ko pathway ratio_in_study ratio_in_pop p_value ko03040 Spliceosome 51/408 145/7206 4.78955483598e-28 ko04110 Cell cycle 45/408 145/7206 3.05850860848e-22 ko04111 Cell cycle - yeast 33/408 90/7206 4.31904858716e-19 ko03460 Fanconi anemia pathway 25/408 51/7206 2.06946554396e-18 ko03440 Homologous recombination 22/408 41/7206 1.91401778741e-17 ko03013 RNA transport 42/408 166/7206 3.81261380582e-17 ko03030 DNA replication 20/408 38/7206 9.51865156527e-16 ko04113 Meiosis - yeast 23/408 70/7206 1.71849663709e-12 ko03008 Ribosome biogenesis in eukaryotes 24/408 79/7206 3.83243503204e-12 ko03410 Base excision repair 15/408 38/7206 7.1188706508e-10 ko00240 Pyrimidine metabolism 25/408 110/7206 1.34813581665e-09 ko03430 Mismatch repair 11/408 22/7206 6.72530868311e-09 ko03018 RNA degradation 20/408 84/7206 2.68508548285e-08 ko03420 Nucleotide excision repair 14/408 46/7206 1.26219962759e-07 ko03015 mRNA surveillance pathway 19/408 93/7206 7.8594880228e-07 ko04144 Endocytosis 3/408 342/7206 5.69248402178e-06 ko04114 Oocyte meiosis 22/408 139/7206 9.54923348472e-06 ko04914 Progesterone-mediated oocyte maturation 18/408 104/7206 1.78866766011e-05 ko05322 Systemic lupus erythematosus 21/408 151/7206 0.000108644538076 ko05166 HTLV-I infection 32/408 292/7206 0.000256096586164 ko05203 Viral carcinogenesis 31/408 277/7206 0.000262677389005 ko05152 Tuberculosis 1/408 187/7206 0.000329690929351 ko04022 cGMP-PKG signaling pathway 2/408 216/7206 0.000487771840181 ko04024 cAMP signaling pathway 4/408 279/7206 0.000514310622855 ko04014 Ras signaling pathway 4/408 279/7206 0.000514310622855 ko04151 PI3K-Akt signaling pathway 8/408 390/7206 0.000637597627764 ko03022 Basal transcription factors 9/408 44/7206 0.000659296921482 ko05205 Proteoglycans in cancer 4/408 271/7206 0.000723305055119 ko04115 p53 signaling pathway 12/408 74/7206 0.000825013921622 ko04810 Regulation of actin cytoskeleton 4/408 264/7206 0.00101415455828 ko04120 Ubiquitin mediated proteolysis 18/408 138/7206 0.00103011921459 ko04218 Cellular senescence 21/408 177/7206 0.00131966583346 ko04724 Glutamatergic synapse 1/408 152/7206 0.00222674853675 ko04270 Vascular smooth muscle contraction 1/408 154/7206 0.00224652394269 ko04621 NOD-like receptor signaling pathway 1/408 157/7206 0.00234398982803 ko04932 Non-alcoholic fatty liver disease (NAFLD) 2/408 182/7206 0.00299966836444 ko04921 Oxytocin signaling pathway 3/408 209/7206 0.00351384720157 ko04510 Focal adhesion 4/408 240/7206 0.00394808852488 ko04010 MAPK signaling pathway 7/408 321/7206 0.00406731199116 ko04723 Retrograde endocannabinoid signaling 2/408 175/7206 0.00428646157449 ko05168 Herpes simplex infection 20/408 182/7206 0.00481586474379 ko05034 Alcoholism 24/408 238/7206 0.00598845174334 ko04072 Phospholipase D signaling pathway 3/408 197/7206 0.00701902973167 ko04713 Circadian entrainment 1/408 136/7206 0.00724895129474 ko04725 Cholinergic synapse 2/408 160/7206 0.00864367755884 ko04145 Phagosome 2/408 162/7206 0.00877005232507 ko04140 Autophagy - animal 2/408 164/7206 0.00899852533264 ko04066 HIF-1 signaling pathway 1/408 123/7206 0.0100066769303 ko01200 Carbon metabolism 1/408 128/7206 0.0103518428476 ko05012 Parkinson's disease 2/408 155/7206 0.0124492732542 ko04310 Wnt signaling pathway 3/408 181/7206 0.0134593844815 ko04360 Axon guidance 5/408 233/7206 0.0136690945193 ko04261 Adrenergic signaling in cardiomyocytes 4/408 205/7206 0.0137484107639 ko04668 TNF signaling pathway 1/408 120/7206 0.0148122991682 ko04666 Fc gamma R-mediated phagocytosis 1/408 122/7206 0.0152692774495 ko04015 Rap1 signaling pathway 7/408 278/7206 0.0166846465075 ko04062 Chemokine signaling pathway 4/408 201/7206 0.0189749282497 ko04371 Apelin signaling pathway 3/408 177/7206 0.0192607813474 ko04727 GABAergic synapse 1/408 110/7206 0.0209928321772 ko05032 Morphine addiction 1/408 110/7206 0.0209928321772 ko00310 Lysine degradation 9/408 73/7206 0.0212946914 ko03020 RNA polymerase 5/408 29/7206 0.0218646540591 ko04931 Insulin resistance 2/408 137/7206 0.0242964254816 ko04726 Serotonergic synapse 2/408 137/7206 0.0242964254816 ko04915 Estrogen signaling pathway 2/408 131/7206 0.0342242657591 ko04728 Dopaminergic synapse 4/408 185/7206 0.0347420415417 ko04380 Osteoclast differentiation 2/408 134/7206 0.0350134599887 ko05231 Choline metabolism in cancer 2/408 134/7206 0.0350134599887 ko04152 AMPK signaling pathway 3/408 161/7206 0.0359958834861 ko00230 Purine metabolism 18/408 194/7206 0.0384629250341 ko04530 Tight junction 6/408 228/7206 0.0410353756194 ko04064 NF-kappa B signaling pathway 1/408 96/7206 0.0437094935619 ko04971 Gastric acid secretion 1/408 98/7206 0.0442494292662 ko04912 GnRH signaling pathway 2/408 122/7206 0.0477178313798 ko04750 Inflammatory mediator regulation of TRP channels 2/408 122/7206 0.0477178313798 ko05145 Toxoplasmosis 2/408 126/7206 0.0486100893784