ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	122/779	423/7206	2.15907760456e-26
ko04724	Glutamatergic synapse	54/779	152/7206	2.47555885351e-16
ko04020	Calcium signaling pathway	67/779	265/7206	1.04217118992e-11
ko05033	Nicotine addiction	26/779	56/7206	1.42087464928e-11
ko04713	Circadian entrainment	43/779	136/7206	2.67766495504e-11
ko04728	Dopaminergic synapse	51/779	185/7206	1.11256807625e-10
ko04911	Insulin secretion	37/779	117/7206	6.65479430377e-10
ko04720	Long-term potentiation	33/779	99/7206	1.23959474012e-09
ko05031	Amphetamine addiction	31/779	91/7206	2.16469469517e-09
ko04727	GABAergic synapse	34/779	110/7206	6.42647678839e-09
ko05032	Morphine addiction	34/779	110/7206	6.42647678839e-09
ko04726	Serotonergic synapse	39/779	137/7206	6.80961789261e-09
ko04024	cAMP signaling pathway	63/779	279/7206	9.21108857137e-09
ko04725	Cholinergic synapse	41/779	160/7206	8.47167473391e-08
ko04921	Oxytocin signaling pathway	49/779	209/7206	9.72268138609e-08
ko04925	Aldosterone synthesis and secretion	31/779	105/7206	9.81762462699e-08
ko04970	Salivary secretion	29/779	95/7206	1.14162957893e-07
ko04261	Adrenergic signaling in cardiomyocytes	48/779	205/7206	1.39132582276e-07
ko04723	Retrograde endocannabinoid signaling	43/779	175/7206	1.69070762892e-07
ko04721	Synaptic vesicle cycle	24/779	80/7206	2.00579503274e-06
ko03040	Spliceosome	1/779	145/7206	2.07706063843e-06
ko04971	Gastric acid secretion	27/779	98/7206	2.92624787737e-06
ko04745	Phototransduction - fly	15/779	38/7206	3.98797937483e-06
ko05322	Systemic lupus erythematosus	2/779	151/7206	8.05597201808e-06
ko03010	Ribosome	1/779	129/7206	1.01153564239e-05
ko04022	cGMP-PKG signaling pathway	45/779	216/7206	1.08118390794e-05
ko04750	Inflammatory mediator regulation of TRP channels	30/779	122/7206	1.1248070893e-05
ko05168	Herpes simplex infection	4/779	182/7206	1.62456983751e-05
ko04070	Phosphatidylinositol signaling system	28/779	112/7206	1.72096147946e-05
ko05030	Cocaine addiction	21/779	73/7206	1.78965664999e-05
ko04744	Phototransduction	13/779	36/7206	5.37722284422e-05
ko04730	Long-term depression	20/779	78/7206	0.00016674390928
ko04540	Gap junction	28/779	128/7206	0.000241865124053
ko04260	Cardiac muscle contraction	23/779	98/7206	0.000247435903291
ko05162	Measles	2/779	120/7206	0.000269120581167
ko03013	RNA transport	5/779	166/7206	0.000328742491413
ko04110	Cell cycle	4/779	145/7206	0.000592612706984
ko04072	Phospholipase D signaling pathway	37/779	197/7206	0.000665300535616
ko04514	Cell adhesion molecules (CAMs)	27/779	130/7206	0.000831855619789
ko04010	MAPK signaling pathway	54/779	321/7206	0.000858804513759
ko05014	Amyotrophic lateral sclerosis (ALS)	18/779	74/7206	0.000896080430171
ko04972	Pancreatic secretion	24/779	111/7206	0.000930380518994
ko05203	Viral carcinogenesis	14/779	277/7206	0.0010269958071
ko04060	Cytokine-cytokine receptor interaction	8/779	191/7206	0.00132820590045
ko04360	Axon guidance	41/779	233/7206	0.00169293744176
ko04626	Plant-pathogen interaction	7/779	18/7206	0.00183006827868
ko04612	Antigen processing and presentation	1/779	77/7206	0.00262980413478
ko04960	Aldosterone-regulated sodium reabsorption	11/779	41/7206	0.00329721525115
ko04120	Ubiquitin mediated proteolysis	5/779	138/7206	0.0033470612199
ko05164	Influenza A	7/779	167/7206	0.00340151338957
ko04922	Glucagon signaling pathway	25/779	128/7206	0.00352312517687
ko05140	Leishmaniasis	1/779	75/7206	0.00404811403399
ko05169	Epstein-Barr virus infection	10/779	206/7206	0.00408115493246
ko04510	Focal adhesion	13/779	240/7206	0.00416131606349
ko04924	Renin secretion	18/779	86/7206	0.004792067829
ko04710	Circadian rhythm	11/779	43/7206	0.00491228761084
ko05222	Small cell lung cancer	2/779	89/7206	0.00514367393537
ko04114	Oocyte meiosis	26/779	139/7206	0.00521123440718
ko05200	Pathways in cancer	35/779	492/7206	0.00526722649304
ko04742	Taste transduction	14/779	61/7206	0.00559155087403
ko04740	Olfactory transduction	17/779	80/7206	0.00562583421196
ko04621	NOD-like receptor signaling pathway	7/779	157/7206	0.00614005479505
ko00680	Methane metabolism	9/779	34/7206	0.00836280470992
ko04810	Regulation of actin cytoskeleton	16/779	264/7206	0.00856792069748
ko04964	Proximal tubule bicarbonate reclamation	8/779	29/7206	0.009769057703
ko04961	Endocrine and other factor-regulated calcium reabsorption	13/779	59/7206	0.0101712470825
ko04918	Thyroid hormone synthesis	17/779	86/7206	0.0129553862487
ko00010	Glycolysis / Gluconeogenesis	15/779	74/7206	0.0135850147181
ko04932	Non-alcoholic fatty liver disease (NAFLD)	10/779	182/7206	0.0154431222749
ko04141	Protein processing in endoplasmic reticulum	10/779	184/7206	0.0155316497727
ko04630	Jak-STAT signaling pathway	6/779	132/7206	0.0155815718253
ko05166	HTLV-I infection	19/779	292/7206	0.0156728445076
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	16/779	79/7206	0.0157812788835
ko00120	Primary bile acid biosynthesis	6/779	20/7206	0.016056520605
ko04657	IL-17 signaling pathway	3/779	87/7206	0.0225617013621
ko05133	Pertussis	3/779	87/7206	0.0225617013621
ko05202	Transcriptional misregulation in cancer	11/779	188/7206	0.023447431234
ko05206	MicroRNAs in cancer	10/779	177/7206	0.0263484712038
ko00520	Amino sugar and nucleotide sugar metabolism	1/779	55/7206	0.0267954864839
ko05416	Viral myocarditis	1/779	55/7206	0.0267954864839
ko05145	Toxoplasmosis	6/779	126/7206	0.0284387694651
ko00360	Phenylalanine metabolism	5/779	17/7206	0.0298445849832
ko05211	Renal cell carcinoma	4/779	96/7206	0.0308083509194
ko04064	NF-kappa B signaling pathway	4/779	96/7206	0.0308083509194
ko05418	Fluid shear stress and atherosclerosis	10/779	173/7206	0.0339450789412
ko05161	Hepatitis B	10/779	173/7206	0.0339450789412
ko04270	Vascular smooth muscle contraction	25/779	154/7206	0.0351011174253
ko04668	TNF signaling pathway	6/779	120/7206	0.0371303140973
ko04210	Apoptosis	11/779	180/7206	0.0383764070843
ko04014	Ras signaling pathway	41/779	279/7206	0.0385223152717
ko00051	Fructose and mannose metabolism	9/779	42/7206	0.0406600132245
ko04973	Carbohydrate digestion and absorption	9/779	42/7206	0.0406600132245
ko05110	Vibrio cholerae infection	12/779	63/7206	0.041500286799
ko05205	Proteoglycans in cancer	19/779	271/7206	0.0452871614319