ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	172/1021	423/7206	6.3033733439e-44
ko04724	Glutamatergic synapse	79/1021	152/7206	7.21715185861e-29
ko05033	Nicotine addiction	43/1021	56/7206	4.36346624318e-26
ko04721	Synaptic vesicle cycle	49/1021	80/7206	1.61602265313e-22
ko04713	Circadian entrainment	66/1021	136/7206	4.19756930383e-22
ko05032	Morphine addiction	57/1021	110/7206	5.15957913743e-21
ko04727	GABAergic synapse	55/1021	110/7206	2.2653817252e-19
ko04728	Dopaminergic synapse	75/1021	185/7206	3.81548100532e-19
ko04725	Cholinergic synapse	68/1021	160/7206	9.05361344564e-19
ko04723	Retrograde endocannabinoid signaling	68/1021	175/7206	2.58117004524e-16
ko04020	Calcium signaling pathway	87/1021	265/7206	4.1314393731e-15
ko04024	cAMP signaling pathway	89/1021	279/7206	1.20561530814e-14
ko04921	Oxytocin signaling pathway	73/1021	209/7206	2.34879634637e-14
ko04911	Insulin secretion	49/1021	117/7206	1.48006179821e-13
ko04742	Taste transduction	33/1021	61/7206	2.17076328366e-13
ko04726	Serotonergic synapse	51/1021	137/7206	1.05466709285e-11
ko04261	Adrenergic signaling in cardiomyocytes	66/1021	205/7206	3.0351473275e-11
ko05031	Amphetamine addiction	37/1021	91/7206	4.13202967283e-10
ko04970	Salivary secretion	38/1021	95/7206	4.2233939307e-10
ko05203	Viral carcinogenesis	10/1021	277/7206	5.93931768346e-09
ko04720	Long-term potentiation	37/1021	99/7206	6.64112867054e-09
ko03040	Spliceosome	1/1021	145/7206	9.10923019336e-09
ko04744	Phototransduction	18/1021	36/7206	3.31518096456e-07
ko04925	Aldosterone synthesis and secretion	35/1021	105/7206	5.49403322766e-07
ko05168	Herpes simplex infection	6/1021	182/7206	1.40360840235e-06
ko05164	Influenza A	5/1021	167/7206	1.62111646341e-06
ko04740	Olfactory transduction	28/1021	80/7206	2.14624158667e-06
ko05322	Systemic lupus erythematosus	4/1021	151/7206	2.62799409417e-06
ko04514	Cell adhesion molecules (CAMs)	39/1021	130/7206	2.63369661365e-06
ko04010	MAPK signaling pathway	76/1021	321/7206	3.58885111667e-06
ko04360	Axon guidance	59/1021	233/7206	5.279531461e-06
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1021	79/7206	5.4626851579e-06
ko04621	NOD-like receptor signaling pathway	5/1021	157/7206	7.28419934296e-06
ko04060	Cytokine-cytokine receptor interaction	8/1021	191/7206	7.78941857327e-06
ko04022	cGMP-PKG signaling pathway	55/1021	216/7206	9.70574374057e-06
ko05030	Cocaine addiction	25/1021	73/7206	1.162326111e-05
ko04971	Gastric acid secretion	31/1021	98/7206	1.19868564815e-05
ko04966	Collecting duct acid secretion	13/1021	26/7206	1.48658547625e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	25/1021	74/7206	1.52317847468e-05
ko04745	Phototransduction - fly	16/1021	38/7206	2.41893826873e-05
ko03013	RNA transport	7/1021	166/7206	3.97863680407e-05
ko04730	Long-term depression	25/1021	78/7206	4.83114058827e-05
ko04260	Cardiac muscle contraction	29/1021	98/7206	6.10130891062e-05
ko04141	Protein processing in endoplasmic reticulum	9/1021	184/7206	6.26322299622e-05
ko04120	Ubiquitin mediated proteolysis	5/1021	138/7206	6.3111037648e-05
ko04972	Pancreatic secretion	31/1021	111/7206	0.000152287601834
ko05414	Dilated cardiomyopathy	31/1021	112/7206	0.000167748261874
ko04612	Antigen processing and presentation	1/1021	77/7206	0.000199062397311
ko05169	Epstein-Barr virus infection	12/1021	206/7206	0.000225581111059
ko04924	Renin secretion	25/1021	86/7206	0.000272316357056
ko05110	Vibrio cholerae infection	20/1021	63/7206	0.00034251805108
ko04110	Cell cycle	7/1021	145/7206	0.00042048451051
ko04540	Gap junction	33/1021	128/7206	0.000458185663893
ko04070	Phosphatidylinositol signaling system	30/1021	112/7206	0.000503034305454
ko05166	HTLV-I infection	22/1021	292/7206	0.000563721623131
ko04064	NF-kappa B signaling pathway	3/1021	96/7206	0.000568794950246
ko05161	Hepatitis B	10/1021	173/7206	0.000577312740364
ko04014	Ras signaling pathway	60/1021	279/7206	0.000810662840981
ko04610	Complement and coagulation cascades	2/1021	79/7206	0.000952322282451
ko03008	Ribosome biogenesis in eukaryotes	2/1021	79/7206	0.000952322282451
ko04146	Peroxisome	3/1021	89/7206	0.00118233349927
ko05140	Leishmaniasis	2/1021	75/7206	0.0013934564258
ko04072	Phospholipase D signaling pathway	44/1021	197/7206	0.00173847972656
ko04626	Plant-pathogen interaction	8/1021	18/7206	0.00184512490842
ko05410	Hypertrophic cardiomyopathy (HCM)	26/1021	100/7206	0.00203943578781
ko04214	Apoptosis - fly	2/1021	72/7206	0.0020399188505
ko04750	Inflammatory mediator regulation of TRP channels	30/1021	122/7206	0.00226876275331
ko05205	Proteoglycans in cancer	22/1021	271/7206	0.00246457067752
ko04961	Endocrine and other factor-regulated calcium reabsorption	17/1021	59/7206	0.00384692938509
ko05162	Measles	7/1021	120/7206	0.00534711487559
ko01524	Platinum drug resistance	3/1021	76/7206	0.00724122944563
ko04915	Estrogen signaling pathway	30/1021	131/7206	0.00732486958214
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1021	14/7206	0.00865880489672
ko04976	Bile secretion	20/1021	80/7206	0.00906573336918
ko04930	Type II diabetes mellitus	15/1021	54/7206	0.00908379041811
ko00330	Arginine and proline metabolism	2/1021	61/7206	0.00911058851608
ko04330	Notch signaling pathway	2/1021	62/7206	0.00924718743881
ko05120	Epithelial cell signaling in Helicobacter pylori infection	22/1021	92/7206	0.0102783702132
ko05219	Bladder cancer	1/1021	48/7206	0.0110355481543
ko04630	Jak-STAT signaling pathway	9/1021	132/7206	0.0114490274885
ko04371	Apelin signaling pathway	37/1021	177/7206	0.0119606544216
ko05215	Prostate cancer	7/1021	111/7206	0.0131691306162
ko04922	Glucagon signaling pathway	28/1021	128/7206	0.0150077029426
ko04964	Proximal tubule bicarbonate reclamation	9/1021	29/7206	0.0155848064003
ko03022	Basal transcription factors	1/1021	44/7206	0.0161149139014
ko05144	Malaria	1/1021	45/7206	0.0163326228412
ko00071	Fatty acid degradation	1/1021	45/7206	0.0163326228412
ko04668	TNF signaling pathway	8/1021	120/7206	0.0166216233727
ko03420	Nucleotide excision repair	1/1021	46/7206	0.0169489165894
ko04932	Non-alcoholic fatty liver disease (NAFLD)	15/1021	182/7206	0.0176643011299
ko00480	Glutathione metabolism	2/1021	55/7206	0.0189787371018
ko05321	Inflammatory bowel disease (IBD)	2/1021	56/7206	0.0192183422124
ko04657	IL-17 signaling pathway	5/1021	87/7206	0.0197295974694
ko05145	Toxoplasmosis	9/1021	126/7206	0.0198943811479
ko04210	Apoptosis	15/1021	180/7206	0.0224784139738
ko00140	Steroid hormone biosynthesis	1/1021	41/7206	0.0238682034403
ko03018	RNA degradation	5/1021	84/7206	0.0268784942918
ko00590	Arachidonic acid metabolism	2/1021	52/7206	0.0272649337865
ko00310	Lysine degradation	4/1021	73/7206	0.0279784087898
ko04622	RIG-I-like receptor signaling pathway	3/1021	62/7206	0.0283580483416
ko00280	Valine, leucine and isoleucine degradation	2/1021	54/7206	0.0283945759273
ko05206	MicroRNAs in cancer	15/1021	177/7206	0.028415466097
ko04217	Necroptosis	15/1021	178/7206	0.0287007621452
ko00562	Inositol phosphate metabolism	20/1021	89/7206	0.031209275659
ko04550	Signaling pathways regulating pluripotency of stem cells	14/1021	165/7206	0.0318096416657
ko03410	Base excision repair	1/1021	38/7206	0.0352788292634
ko05418	Fluid shear stress and atherosclerosis	15/1021	173/7206	0.0355823939472
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1021	40/7206	0.036727610829
ko05131	Shigellosis	5/1021	82/7206	0.0368161756357
ko00240	Pyrimidine metabolism	8/1021	110/7206	0.0377432204332
ko04510	Focal adhesion	23/1021	240/7206	0.0381080584734
ko00380	Tryptophan metabolism	2/1021	50/7206	0.0394631940598
ko05222	Small cell lung cancer	6/1021	89/7206	0.045511027659
ko04114	Oocyte meiosis	28/1021	139/7206	0.04871622528
ko04912	GnRH signaling pathway	25/1021	122/7206	0.0492180954905