Method of omim prediction
We use the RWRH (random walk with restart on heterogeneous network) algorithm1 to analyze the relationship between lncRNA and OMIM in MATLAB. The upper subnetwork is coding-lncRNA gene co-expression network, and the lower network is OMIM similarity network. OMIM similarity matrix is from Disimweb2 and gene-OMIM relationship is from InterMine3.
1. Li, Y. & Patra, J. C. Genome-wide inferring gene-phenotype relationship by walking on the heterogeneous network. Bioinformatics 26, 1219-1224, doi:10.1093/bioinformatics/btq108 (2010).
2. Caniza, H., Romero, A. E. & Paccanaro, A. A network medicine approach to quantify distance between hereditary disease modules on the interactome. Sci Rep 5, 17658, doi:10.1038/srep17658 (2015).
3. Smith, R. N. et al. InterMine: a flexible data warehouse system for the integration and analysis of heterogeneous biological data. Bioinformatics 28, 3163-3165, doi:10.1093/bioinformatics/bts577 (2012).
| ZFLNC lncRNA | OMIM | Phenotype |
|---|---|---|
| ZFLNCG08399 | 180105 | Retinitis pigmentosa 10 |
| ZFLNCG04674 | 228000 | Farber lipogranulomatosis |
| ZFLNCG01897 | 613810 | Retinitis pigmentosa 43 |
| ZFLNCG12039 | 609532 | Hepatitic C virus, susceptibility to |
| ZFLNCG06936 | 610093 | Microphthalmia, isolated 2 |
| ZFLNCG11358 | 312300 | Androgen insensitivity, partial, with or without breast cancer |
| ZFLNCG09934 | 228000 | Farber lipogranulomatosis |
| ZFLNCG05701 | 614195 | Craniofacial anomalies and anterior segment dysgenesis syndrome |
| ZFLNCG00825 | 300915 | Microphthalmia, syndromic 13 |
| ZFLNCG05213 | 156610 | Symmetric circumferential skin creases, congenital, 1 |
| ZFLNCG08214 | 615517 | Hemochromatosis, type 5 |
| ZFLNCG09823 | 600072 | Insomnia, fatal familial |
| ZFLNCG07882 | 608232 | Leukemia, chronic myeloid, somatic |
| ZFLNCG07316 | 610743 | Spinocerebellar ataxia, autosomal recessive 8 |
| ZFLNCG00713 | 609532 | Hepatitic C virus, susceptibility to |
| ZFLNCG04391 | 112410 | Hypertension and brachydactyly syndrome |
| ZFLNCG06936 | 610092 | Microphthalmia with coloboma 3 |
| ZFLNCG10483 | 601536 | Bosley-Salih-Alorainy syndrome |
| ZFLNCG08626 | 601419 | Myopathy, myofibrillar, 1 |
| ZFLNCG08615 | 131750 | Epidermolysis bullosa dystrophica, AD |
| ZFLNCG06123 | 601088 | Ayme-Gripp syndrome |
| ZFLNCG11173 | 613310 | Exudative vitreoretinopathy 5 |
| ZFLNCG02289 | 611664 | Skin/hair/eye pigmentation 7, blond/brown hair |
| ZFLNCG03687 | 611724 | Skin/hair/eye pigmentation, variation in, 8 |
| ZFLNCG12788 | 302350 | Nance-Horan syndrome |