Method of omim prediction
We use the RWRH (random walk with restart on heterogeneous network) algorithm1 to analyze the relationship between lncRNA and OMIM in MATLAB. The upper subnetwork is coding-lncRNA gene co-expression network, and the lower network is OMIM similarity network. OMIM similarity matrix is from Disimweb2 and gene-OMIM relationship is from InterMine3.
1. Li, Y. & Patra, J. C. Genome-wide inferring gene-phenotype relationship by walking on the heterogeneous network. Bioinformatics 26, 1219-1224, doi:10.1093/bioinformatics/btq108 (2010).
2. Caniza, H., Romero, A. E. & Paccanaro, A. A network medicine approach to quantify distance between hereditary disease modules on the interactome. Sci Rep 5, 17658, doi:10.1038/srep17658 (2015).
3. Smith, R. N. et al. InterMine: a flexible data warehouse system for the integration and analysis of heterogeneous biological data. Bioinformatics 28, 3163-3165, doi:10.1093/bioinformatics/bts577 (2012).
| ZFLNC lncRNA | OMIM | Phenotype |
|---|---|---|
| ZFLNCG09397 | 610227 | Seborrhea-like dermatitis with psoriasiform elements |
| ZFLNCG11073 | 109730 | Aortic valve disease 1 |
| ZFLNCG02067 | 186500 | Multiple synostoses syndrome 1 |
| ZFLNCG05574 | 268220 | Rhabdomyosarcoma 2, alveolar |
| ZFLNCG07461 | 170390 | Andersen syndrome |
| ZFLNCG05355 | 600858 | Cardiomyopathy, hypertrophic 6 |
| ZFLNCG04642 | 604145 | Cardiomyopathy, dilated, 1G |
| ZFLNCG05577 | 611773 | Angiopathy, hereditary, with nephropathy, aneurysms, and muscle cramps |
| ZFLNCG06056 | 610954 | Pitt-Hopkins syndrome |
| ZFLNCG00113 | 231095 | Ghosal hematodiaphyseal syndrome |
| ZFLNCG05895 | 612551 | Glomerulosclerosis, focal segmental, 4, susceptibility to |
| ZFLNCG01407 | 169100 | Char syndrome |
| ZFLNCG13032 | 300004 | Proud syndrome |
| ZFLNCG07882 | 613065 | Leukemia, acute lymphoblastic |
| ZFLNCG10914 | 185000 | Overhydrated hereditary stomatocytosis |
| ZFLNCG05701 | 148300 | Keratoconus 1 |
| ZFLNCG09198 | 615518 | Immunodeficiency 13 |
| ZFLNCG06817 | 613660 | Retinitis pigmentosa 65 |
| ZFLNCG06609 | 612736 | Cerebral creatine deficiency syndrome 2 |
| ZFLNCG03410 | 603218 | Huntington disease-like 1 |
| ZFLNCG00609 | 209900 | Bardet-Biedl syndrome 1, modifier of |
| ZFLNCG06562 | 604841 | Stickler syndrome, type II |
| ZFLNCG01532 | 602723 | Psoriasis 2 |
| ZFLNCG11786 | 277480 | von Willibrand disease, type 3 |
| ZFLNCG03410 | 137440 | Gerstmann-Straussler disease |