We use the RWRH (random walk with restart on heterogeneous network) algorithm1 to analyze the relationship between lncRNA and OMIM in MATLAB. The upper subnetwork is coding-lncRNA gene co-expression network, and the lower network is OMIM similarity network. OMIM similarity matrix is from Disimweb2 and gene-OMIM relationship is from InterMine3.
1. Li, Y. & Patra, J. C. Genome-wide inferring gene-phenotype relationship by walking on the heterogeneous network. Bioinformatics 26, 1219-1224, doi:10.1093/bioinformatics/btq108 (2010).
2. Caniza, H., Romero, A. E. & Paccanaro, A. A network medicine approach to quantify distance between hereditary disease modules on the interactome. Sci Rep 5, 17658, doi:10.1038/srep17658 (2015).
3. Smith, R. N. et al. InterMine: a flexible data warehouse system for the integration and analysis of heterogeneous biological data. Bioinformatics 28, 3163-3165, doi:10.1093/bioinformatics/bts577 (2012).
ZFLNC lncRNA | OMIM | Phenotype |
---|---|---|
ZFLNCG03524 | 147891 | Small patella syndrome |
ZFLNCG07029 | 614424 | Joubert syndrome 14 |
ZFLNCG05975 | 265450 | Pulmonary venoocclusive disease 1 |
ZFLNCG01693 | 225320 | Ehlers-Danlos syndrome, cardiac valvular form |
ZFLNCG13482 | 615377 | Atrial fibrillation, familial, 13 |
ZFLNCG11824 | 219200 | Cutis laxa, autosomal recessive, type IIA |
ZFLNCG03614 | 147250 | Single median maxillary central incisor |
ZFLNCG02042 | 170390 | Andersen syndrome |
ZFLNCG01355 | 609283 | Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal dominant 2 |
ZFLNCG06950 | 615413 | Spermatogenic failure 12 |
ZFLNCG12788 | 302200 | Cataract 40, X-linked |
ZFLNCG08726 | 276710 | Tyrosinemia, type III |
ZFLNCG13032 | 308350 | Epileptic encephalopathy, early infantile, 1 |
ZFLNCG10712 | 609924 | Aminoacylase 1 deficiency |
ZFLNCG12156 | 612291 | Joubert syndrome 8 |
ZFLNCG09823 | 123400 | Creutzfeldt-Jakob disease |
ZFLNCG04859 | 613671 | Mental retardation, anterior maxillary protrusion, and strabismus |
ZFLNCG11375 | 612271 | Skin/hair/eye pigmentation, variation in, 11 (Melanesian blond hair) |
ZFLNCG03375 | 201710 | Lipoid adrenal hyperplasia |
ZFLNCG06609 | 250850 | Methionine adenosyltransferase deficiency, autosomal recessive |
ZFLNCG03547 | 615512 | Hemolytic anemia due to triosephosphate isomerase deficiency |
ZFLNCG04509 | 611277 | Febrile seizures, familial, 8 |
ZFLNCG06198 | 147250 | Single median maxillary central incisor |
ZFLNCG05895 | 142680 | Periodic fever, familial |
ZFLNCG06743 | 309510 | Partington syndrome |