Method of omim prediction
We use the RWRH (random walk with restart on heterogeneous network) algorithm1 to analyze the relationship between lncRNA and OMIM in MATLAB. The upper subnetwork is coding-lncRNA gene co-expression network, and the lower network is OMIM similarity network. OMIM similarity matrix is from Disimweb2 and gene-OMIM relationship is from InterMine3.
1. Li, Y. & Patra, J. C. Genome-wide inferring gene-phenotype relationship by walking on the heterogeneous network. Bioinformatics 26, 1219-1224, doi:10.1093/bioinformatics/btq108 (2010).
2. Caniza, H., Romero, A. E. & Paccanaro, A. A network medicine approach to quantify distance between hereditary disease modules on the interactome. Sci Rep 5, 17658, doi:10.1038/srep17658 (2015).
3. Smith, R. N. et al. InterMine: a flexible data warehouse system for the integration and analysis of heterogeneous biological data. Bioinformatics 28, 3163-3165, doi:10.1093/bioinformatics/bts577 (2012).
| ZFLNC lncRNA | OMIM | Phenotype |
|---|---|---|
| ZFLNCG08297 | 613216 | Night blindness, congenital stationary (complete), 1C, autosomal recessive |
| ZFLNCG03375 | 612286 | Nephrolithiasis/osteoporosis, hypophosphatemic, 1 |
| ZFLNCG09576 | 610125 | Retinal dystrophy, early-onset, with or without pituitary dysfunction |
| ZFLNCG06817 | 204000 | Leber congenital amaurosis 1 |
| ZFLNCG04859 | 612998 | Emery-Dreifuss muscular dystrophy 4, autosomal dominant |
| ZFLNCG10304 | 142680 | Periodic fever, familial |
| ZFLNCG09934 | 159950 | Spinal muscular atrophy with progressive myoclonic epilepsy |
| ZFLNCG02390 | 612551 | Glomerulosclerosis, focal segmental, 4, susceptibility to |
| ZFLNCG10755 | 104290 | Alternating hemiplegia of childhood |
| ZFLNCG03524 | 612109 | Oculoauricular syndrome |
| ZFLNCG12109 | 209300 | Atransferrinemia |
| ZFLNCG07208 | 614810 | Multiple sclerosis, susceptibility to, 5 |
| ZFLNCG12564 | 614847 | Epilepsy, idiopathic generalized, susceptibility to, 12 |
| ZFLNCG12313 | 614495 | Pseudohypoaldosteronism, type IID |
| ZFLNCG08591 | 612551 | Glomerulosclerosis, focal segmental, 4, susceptibility to |
| ZFLNCG11375 | 203290 | Albinism, oculocutaneous, type III |
| ZFLNCG05097 | 310500 | Night blindness, congenital stationary (complete), 1A, X-linked |
| ZFLNCG07651 | 193510 | Waardenburg syndrome, type 2A |
| ZFLNCG09823 | 137440 | Gerstmann-Straussler disease |
| ZFLNCG08591 | 607507 | Psoriatic arthritis, susceptibility to |
| ZFLNCG08627 | 605462 | Basal cell carcinoma, somatic |
| ZFLNCG05132 | 300751 | Anemia, sideroblastic, X-linked |
| ZFLNCG06494 | 615135 | Maple syrup urine disease, mild variant |
| ZFLNCG10638 | 614495 | Pseudohypoaldosteronism, type IID |
| ZFLNCG00113 | 614158 | Thromboxane synthase deficiency |