Method of omim prediction
We use the RWRH (random walk with restart on heterogeneous network) algorithm1 to analyze the relationship between lncRNA and OMIM in MATLAB. The upper subnetwork is coding-lncRNA gene co-expression network, and the lower network is OMIM similarity network. OMIM similarity matrix is from Disimweb2 and gene-OMIM relationship is from InterMine3.
1. Li, Y. & Patra, J. C. Genome-wide inferring gene-phenotype relationship by walking on the heterogeneous network. Bioinformatics 26, 1219-1224, doi:10.1093/bioinformatics/btq108 (2010).
2. Caniza, H., Romero, A. E. & Paccanaro, A. A network medicine approach to quantify distance between hereditary disease modules on the interactome. Sci Rep 5, 17658, doi:10.1038/srep17658 (2015).
3. Smith, R. N. et al. InterMine: a flexible data warehouse system for the integration and analysis of heterogeneous biological data. Bioinformatics 28, 3163-3165, doi:10.1093/bioinformatics/bts577 (2012).
| ZFLNC lncRNA | OMIM | Phenotype |
|---|---|---|
| ZFLNCG05561 | 614063 | N-acetylaspartate deficiency |
| ZFLNCG05957 | 613765 | Cardiomyopathy, familial hypertrophic, 9 |
| ZFLNCG02289 | 145250 | Hyperpigmentation with or without hypopigmentation |
| ZFLNCG12733 | 605432 | Radioulnar synostosis with amegakaryocytic thrombocytopenia 1 |
| ZFLNCG10257 | 312700 | Retinoschisis |
| ZFLNCG06743 | 300419 | Mental retardation, X-linked 29 and others |
| ZFLNCG11375 | 227240 | Skin/hair/eye pigmentation 5, dark/light eyes |
| ZFLNCG10706 | 614049 | Atrial fibrillation, familial, 11 |
| ZFLNCG02385 | 607476 | Newfoundland rod-cone dystrophy |
| ZFLNCG09823 | 610478 | Retinal cone dystrophy 4 |
| ZFLNCG12557 | 610092 | Microphthalmia with coloboma 3 |
| ZFLNCG00765 | 171300 | Pheochromocytoma |
| ZFLNCG00614 | 108600 | Spastic ataxia 1, autosomal dominant |
| ZFLNCG04946 | 612998 | Emery-Dreifuss muscular dystrophy 4, autosomal dominant |
| ZFLNCG01372 | 278250 | Wrinkly skin syndrome |
| ZFLNCG08194 | 149730 | LADD syndrome |
| ZFLNCG01693 | 166220 | Osteogenesis imperfecta, type IV |
| ZFLNCG10171 | 612975 | Short sleeper |
| ZFLNCG12405 | 613957 | Spermatogenic failure 8 |
| ZFLNCG03614 | 269160 | Schizencephaly |
| ZFLNCG08579 | 177735 | Pseudohypoaldosteronism type I, autosomal dominant |
| ZFLNCG12564 | 606777 | GLUT1 deficiency syndrome 1, infantile onset, severe |
| ZFLNCG09557 | 612703 | Microcephaly 7, primary, autosomal recessive |
| ZFLNCG06563 | 301050 | Alport syndrome |
| ZFLNCG07084 | 108600 | Spastic ataxia 1, autosomal dominant |