Method of omim prediction
We use the RWRH (random walk with restart on heterogeneous network) algorithm1 to analyze the relationship between lncRNA and OMIM in MATLAB. The upper subnetwork is coding-lncRNA gene co-expression network, and the lower network is OMIM similarity network. OMIM similarity matrix is from Disimweb2 and gene-OMIM relationship is from InterMine3.
1. Li, Y. & Patra, J. C. Genome-wide inferring gene-phenotype relationship by walking on the heterogeneous network. Bioinformatics 26, 1219-1224, doi:10.1093/bioinformatics/btq108 (2010).
2. Caniza, H., Romero, A. E. & Paccanaro, A. A network medicine approach to quantify distance between hereditary disease modules on the interactome. Sci Rep 5, 17658, doi:10.1038/srep17658 (2015).
3. Smith, R. N. et al. InterMine: a flexible data warehouse system for the integration and analysis of heterogeneous biological data. Bioinformatics 28, 3163-3165, doi:10.1093/bioinformatics/bts577 (2012).
| ZFLNC lncRNA | OMIM | Phenotype |
|---|---|---|
| ZFLNCG13186 | 105210 | Amyloidosis, hereditary, transthyretin-related |
| ZFLNCG12387 | 613843 | Leber congenital amaurosis 15 |
| ZFLNCG01595 | 607785 | Leukemia, juvenile myelomonocytic, somatic |
| ZFLNCG08635 | 268210 | Rhabdomyosarcoma, somatic |
| ZFLNCG05758 | 304110 | Craniofrontonasal dysplasia |
| ZFLNCG04393 | 606843 | Immunodeficiency with hyper-IgM, type 3 |
| ZFLNCG05577 | 158810 | Bethlem myopathy 1 |
| ZFLNCG08591 | 186580 | Blau syndrome |
| ZFLNCG08591 | 609464 | Sarcoidosis, early-onset |
| ZFLNCG07651 | 612716 | Dystonia, dopa-responsive, due to sepiapterin reductase deficiency |
| ZFLNCG09948 | 612998 | Emery-Dreifuss muscular dystrophy 4, autosomal dominant |
| ZFLNCG09551 | 610092 | Microphthalmia with coloboma 3 |
| ZFLNCG05957 | 604145 | Cardiomyopathy, dilated, 1G |
| ZFLNCG04920 | 613980 | Atrial fibrillation, familial, 9 |
| ZFLNCG05682 | 614286 | Myelodysplastic syndrome, somatic |
| ZFLNCG06066 | 271980 | Succinic semialdehyde dehydrogenase deficiency |
| ZFLNCG08627 | 150699 | Leiomyoma, uterine, somatic |
| ZFLNCG08627 | 109400 | Basal cell nevus syndrome |
| ZFLNCG12546 | 608931 | Myasthenic syndrome, congenital, 4C, associated with acetylcholine receptor deficiency |
| ZFLNCG06953 | 610829 | Holoprosencephaly-9 |
| ZFLNCG01477 | 108600 | Spastic ataxia 1, autosomal dominant |
| ZFLNCG11173 | 615441 | Ventricular tachycardia, catecholaminergic polymorphic, 5, with or without muscle weakness |
| ZFLNCG05386 | 612775 | Cone-rod dystrophy 9 |
| ZFLNCG07294 | 164280 | Feingold syndrome |
| ZFLNCG05957 | 603689 | Myopathy, proximal, with early respiratory muscle involvement |