Method of omim prediction
We use the RWRH (random walk with restart on heterogeneous network) algorithm1 to analyze the relationship between lncRNA and OMIM in MATLAB. The upper subnetwork is coding-lncRNA gene co-expression network, and the lower network is OMIM similarity network. OMIM similarity matrix is from Disimweb2 and gene-OMIM relationship is from InterMine3.
1. Li, Y. & Patra, J. C. Genome-wide inferring gene-phenotype relationship by walking on the heterogeneous network. Bioinformatics 26, 1219-1224, doi:10.1093/bioinformatics/btq108 (2010).
2. Caniza, H., Romero, A. E. & Paccanaro, A. A network medicine approach to quantify distance between hereditary disease modules on the interactome. Sci Rep 5, 17658, doi:10.1038/srep17658 (2015).
3. Smith, R. N. et al. InterMine: a flexible data warehouse system for the integration and analysis of heterogeneous biological data. Bioinformatics 28, 3163-3165, doi:10.1093/bioinformatics/bts577 (2012).
| ZFLNC lncRNA | OMIM | Phenotype |
|---|---|---|
| ZFLNCG00113 | 606324 | Parkinson disease 7, autosomal recessive early-onset |
| ZFLNCG07316 | 300352 | Cerebral creatine deficiency syndrome 1 |
| ZFLNCG11409 | 613980 | Atrial fibrillation, familial, 9 |
| ZFLNCG12564 | 608885 | Stomatin-deficient cryohydrocytosis with neurologic defects |
| ZFLNCG05559 | 232240 | Glycogen storage disease Ic |
| ZFLNCG10716 | 300582 | Short stature, idiopathic familial |
| ZFLNCG03375 | 263800 | Gitelman syndrome |
| ZFLNCG10706 | 108770 | Atrial standstill, digenic (GJA5/SCN5A) |
| ZFLNCG10706 | 612964 | Premature ovarian failure 7 |
| ZFLNCG06198 | 269160 | Schizencephaly |
| ZFLNCG12313 | 604233 | Epilepsy, generalized, with febrile seizures plus, type 1 |
| ZFLNCG12995 | 170390 | Andersen syndrome |
| ZFLNCG13032 | 300419 | Mental retardation, X-linked 29 and others |
| ZFLNCG05577 | 607595 | Brain small vessel disease with or without ocular anomalies |
| ZFLNCG07254 | 611544 | Cataract 17, multiple types |
| ZFLNCG04859 | 610743 | Spinocerebellar ataxia, autosomal recessive 8 |
| ZFLNCG06931 | 142945 | Holoprosencephaly-3 |
| ZFLNCG00015 | 610227 | Seborrhea-like dermatitis with psoriasiform elements |
| ZFLNCG08477 | 209300 | Atransferrinemia |
| ZFLNCG05577 | 175780 | Porencephaly 1 |
| ZFLNCG04372 | 120430 | Morning glory disc anomaly |
| ZFLNCG08327 | 603776 | Low density lipoprotein cholesterol level QTL 1 |
| ZFLNCG09755 | 612838 | Cardiac conduction defect, nonspecific |
| ZFLNCG07651 | 103500 | Tietz albinism-deafness syndrome |
| ZFLNCG09301 | 256800 | Insensitivity to pain, congenital, with anhidrosis |